Value of gallbladder-preserving partial cholecystectomy in treatment of abnormal gallbladder morphology complicated by sand-like calculous cholecystitis

Liang FaSheng; Lan YunXia; Liang Jie; Ding Jie; Gao XiaoJun

doi:10.3969/j.issn.1001-5256.2016.10.022

Issue 10

Oct. 2016

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2016 > 32(10): 1932-1935

PDF( 348 KB)

Value of gallbladder-preserving partial cholecystectomy in treatment of abnormal gallbladder morphology complicated by sand-like calculous cholecystitis

DOI: 10.3969/j.issn.1001-5256.2016.10.022

Second Department of Hepatobiliary Surgery, Dalian Friendship Hospital Affiliated to Dalian Medical University

Published Date: 2016-10-20

Abstract

Abstract

Objective To investigate the value of laparoscopic gallbladder-preserving partial cholecystectomy in the treatment of abnormal gallbladder morphology complicated by sand-like calculous cholecystitis. Methods A total of 18 patients with abnormal gallbladder morphology complicated by sand-like calculous cholecystitis who underwent laparoscopic and choledochoscopic partial cholecystectomy in Dalian Friendship Hospital from July 2010 to January 2014 were enrolled. All the patients had abnormal gallbladder morphology manifested as folded gallbladder or adenomyosis,and the lesions were located in the distal end of the gallbladder. Before the surgery,gallbladder contraction test was performed for the diseased part and the normal part of the gallbladder to be preserved. During the surgery,choledochoscopy showed an unobstructed cystic duct and good elasticity in the gallbladder wall,and there was no marked chronic inflammation. After the diseased part of the gallbladder was removed,4-0 absorbable suture was used for two-layer consecutive suture of the gallbladder. The t-test was used for comparison of continuous data between groups. Results All the patients underwent the surgery successfully. The mean time of operation was 98. 0± 9. 0 minutes,and the mean time to first flatus was 22. 8 ± 2. 5 hours. The patients were able to get out of the bed and drink water at 6 hours after surgery and to have meals at 24 hours after surgery. They fully recovered and were discharged at 5-7 days after surgery,and no patient experienced the complications such as bile leakage. The patients were followed up for 6-80 months; the patients' preoperative clinical symptoms disappeared,and there was no recurrence of calculi. At 6-12 months after surgery,the patients experienced compensated cholecystectasis,and there was a significant increase in the mean volume of the gallbladder after surgery( 30. 29 ± 4. 23 cm3 vs 21. 72 ± 4. 34 cm3,t =-13.00,P < 0. 001). There was a significant increase in mean gallbladder contraction after surgery( 56. 9% ± 10. 9% vs 48. 5% ± 12. 7%,t =-6. 11,P < 0. 001). Conclusion In the treatment of abnormal gallbladder morphology complicated by sand-like calculous cholecystitis,laparoscopic and choledochoscopic gallbladder-preserving partial cholecystectomy plays an important role in protecting the gallbladder and its function.It may become a new surgical procedure in gallbladder-preserving surgical treatment when its indications are strictly followed.
- cholecystitis,
- cholecystectomy,
- laparoscopic

FullText(HTML)

References(15)

References

[1]ZHANG P,YU CH.Clinical analysis of relationship between gallstone morphology and biliary pancreatitis[J].J Clin Hepatol,2014,30(1):46-49.(in Chinese)张鹏,于聪慧.胆囊结石形态与胆源性胰腺炎关系的临床分析[J].临床肝胆病杂志,2014,30(1):46-49.

[2]PARK JS,LEE DH,LIM JH,et al.Morphologic factors of biliary trees are associated with gallstone-related biliary events[J].World J Gastoneterol,2015,21(1):276-282.

[3]LIANG FS,LIANG J,LAN YX,et al.Application of with laparoscopic to treat gallbladder disease of preservation cholecyst in partial cholecystectomy[J/CD].Chin J Laparoscopic Surgery:Electronic Edition,2014,7(3):45-48.(in Chinese)梁法生,梁杰,兰云霞,等.腹腔镜胆囊部分切除术在保胆中的应用[J/CD].中华腔镜外科杂志:电子版,2014,7(3):45-48.

[4] LIANG FS,SHEN HL,DING J,et al.Partial cholecystectomy with laparoscope and choledochoscope in treatment of gallbladder deformity:with a report of 14 cases[J].J Laparo Surg,2012,17(3):177-179.(in Chinese)梁法生,沈慧琳,丁洁,等.腹腔镜联合胆道镜胆囊部分切除术治疗胆囊畸形(附14例报告)[J].腹腔镜外科杂志,2012,17(3):177-179.

[5]JIN SQ.Practical anatomy for surgeons[M].Xi'an:World Book Inc,2007:366.(in Chinese)金绍岐.实用外科解剖学[M].西安:世界图书出版公司,2007:366.

[6]LI J,WEI XG,LU QM,et al.Research advances in association between diseases outside the gallbladder and gallstones[J].J Clin Hepatol,2016,32(5):1018-1021.(in Chinese)李娟,魏小果,卢启明,等.胆外疾病与胆囊结石相关性的研究[J].临床肝胆病杂志,2016,32(5):1018-1021.

[7]CHEN Y,KONG J,WU S.Cholesterol gallstone disease:focusing on the role of gallblader[J].Lab Invest,2015,95(2):124-131.

[8]de BARI O,WANG TY,LIU M,et al.Cholesterol cholelithiasis in pregnant women:pathogenesis,prevention and treatment[J].Ann Hepatol,2014,13(6):728-745.

[9]ZAMANI F,SOHRABI M,ALIPOUR A,et al.Prevalence and risk factors of cholelithiasis in Amol city,northern Iran:a population based study[J].Arch Iran med,2014,17(11):750-754.

[10]AUNE D,NOTAT T,VATTEN LJ.Body mass index,abdominal fatness and the risk of gallbladder disease[J].Eur J Epidemiol,2015,30(9):1009-1019.

[11]QIAO T,LUO XB,MA RH,et al.Relationship between morphological changes and survival status of Clonorchis sinensis eggs and gallstone formation[J].World Chin J Dig,2013,21(33):3638-3646.(in Chinese)乔铁,罗小兵,马瑞红,等.华支睾吸虫卵的形态变化、存活状况与胆囊结石形成的关系[J].世界华人消化杂志,2013,21(33):3638-3646.

[12]GU YC,HE XD,YU JC,et al.Metabolism-related risk factors of cholelithiasis among Beijing residents:a case-control study[J].Acta Acad Med Sin,2012,34(1):38-40.(in Chinese)古应超,何小东,于健春,等.北京地区代谢因素与胆囊结石患病风险的病例对照研究[J].中国医学科学报,2012,34(1):38-40.

[13]ZONG CH,WU SW,ZHANG C,et al.Analysis of microbial spectrum in patients with cholecystolithiasis[J].Chin J Surg Integr Tradit West Med,2014,20(5):467-470.(in Chinese)宗春辉,吴尚为,张辰,等.胆囊结石患者主要感染病原菌谱分析[J].中国中西医结合外科杂志,2014,20(5):467-470.

[14]LIANG FS,SHEN HL,HAN AP,et al.Application of with laparoscopic to treating gallbladder deformity of preservation cholecyst in partial cholecystectomy:a reports of 55 cases[J].J Hepatobiliary Surg,2013,21(5):348-350.(in Chinese)梁法生,沈慧琳,韩爱萍,等.腹腔镜胆囊部分切除术保胆治疗胆囊畸形[J].肝胆外科杂志,2013,21(5):348-350.

[15]ZHANG BS.Minimally invasive endoscopic gallbladder preserving therapy for gallbladder polyps[J].China J Endosc,2002,8(3):1-2,7.(in Chinese)张宝善.内镜微创保胆治疗胆囊息肉[J].中国内镜杂志,2002,8(3):1-2,7.

Relative Articles

[1]	Tong LIU, Shanzheng LI, Cheng ZHOU, Sutong LIU, Lihui ZHANG, Wenxia ZHAO. Study on the protective efect and mechanism of paeoniflorin on palmitic acid-induced HepG2 cells[J]. Journal of Clinical Hepatology, 2025, 41(3): 499-505. doi: 10.12449/JCH250316
[2]	Lai Xin, Zhou TaiCheng, Wei Jia. Association between HBV A1762T/G1764A double nucleotide substitution and liver diseases[J]. Journal of Clinical Hepatology, 2018, 34(9): 1990-1994. doi: 10.3969/j.issn.1001-5256.2018.09.034
[3]	Pang Ting, Xing HuiChun. Correlation between drug-resistance gene mutations and hepatocellular carcinoma in patients with hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2017, 33(1): 82-86. doi: 10.3969/j.issn.1001-5256.2017.01.017
[4]	Du SenRong, Mao XiaoRong, Xiao Ping, Chen Hong. Effects of PARP-1 inhibitors AG-014699 and AZD2281 on proliferation and apoptosis of human hepatoma cell line HepG2[J]. Journal of Clinical Hepatology, 2015, 31(6): 943-946. doi: 10.3969/j.issn.1001-5256.2015.06.027
[5]	Wang LiPing, Han FangZheng, Li ChunYang, Yan Mei, Zhang YanChao, Yan XueBing. Evaluation of adefovir primary resistance and adefovir repulsive mutations of the HBV DNA P gene in chronic hepatitis B patients[J]. Journal of Clinical Hepatology, 2012, 28(8): 606-608.
[6]	Jin WenWen, Xin YongNing, Dong QuanJiang, Zhao ShouFeng, Yu XinJuan, Jiang Man, Xu Jing, Xuan ShiYing. The preliminary study on the relationship between hepatitis B virus BCP gene mutations and HBV-related primary hepatocellular carcinoma in Qingdao[J]. Journal of Clinical Hepatology, 2012, 28(2): 130-134.
[7]	Yang YanLin, Xiao Ping, Gao Peng, Wang LiMing, Wei XiSheng, He Qiang, Zhou Ping. Distribution of HBV genotypes and YMDD mutations in E antigen-positive patients[J]. Journal of Clinical Hepatology, 2012, 28(6): 428-430.
[8]	Hong YuBo, Zhang Ting, Sun LiGuang. Association between IL-2 +114 (G/T) polymorphism and susceptibility to hepatitis B, cirrhosis, and hepatocellular carcinoma in Jilin province[J]. Journal of Clinical Hepatology, 2012, 28(12): 930-933.
[9]	Deng Le, Wen ZhiLi. Review of recent research progress in correlating HBV genotypes with efficacy of antiviral treatments[J]. Journal of Clinical Hepatology, 2012, 28(6): 469-473.
[10]	Zhang JianJun, Wu LiPing, Du RuiQing, Wang JianBin, Yao ZhanCheng, Yu GuiQin. Factors correlating with the liver inflammation grade ≥G2 in chronic HBV-infected patients with normal liver function[J]. Journal of Clinical Hepatology, 2012, 28(1): 35-38.
[11]	Liu JinPing, Liu YouDe, Guo YanMei, Yang ShaoPing, Lin Qing, Lin Ling. Clinical characteristics and distribution of hepatitis B virus genotypes in CHB patients in Yantai area[J]. Journal of Clinical Hepatology, 2011, 27(12): 1288-1290.
[12]	Zou XiaoJing, Jiang XueQiang, Tian DeYing. Role of DC-SIGN on the maturation and activation of dendritic cells in chronic hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2011, 27(2): 145-147+153.
[13]	Xiong QiXiang, Xiong LiJuan. Hepatitis B virus infection and DNA methylation in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2011, 27(8): 881-884.
[14]	Pan Lei, Wei Xin, Xie YuMei, Hao ChunQiu, Wang JiuPing, Jia ZhanSheng, Bai XueFan. Anti-viral therapy with pegylated interferon alpha-2a plus ribavirin in patients co-infected with HBV and HCV[J]. Journal of Clinical Hepatology, 2011, 27(1): 84-85+95.
[15]	Yuan JianGuo, Wang XinGuo, Cui Xia, Liu FengHua, Wang FengHua, Song JiKui, Zhao HongKui. The activation of rat hepatic stellate cells stimulated with hepatitis B virus in vitro[J]. Journal of Clinical Hepatology, 2011, 27(2): 163-165.
[16]	Xi HongLi, Liu FangFang, Yuan JiaYing, Yu YanYan. Significance and detection of IL-2、IL-4 and IFN-γ in PBMC from patients with hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2010, 26(6): 627-629.
[17]	Wang GuoQiang, Niu JuXia. The HBx protein mutation among different HBV genotypes[J]. Journal of Clinical Hepatology, 2010, 26(4): 392-394.
[18]	Shi YanMei, Lan YingHua, Dan Lei, Zhou Jin, Li YongGuo. The relationship between of hematopoietic stem cells and hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2010, 26(4): 377-380.
[19]	Xie DeSheng, Zhang QingBo, Chen ChangXing, Huang JianFang, Ma Jin, Huang HaiBin, Du Yao. The relationship between HBV gene mutation in HBV infected family and HLA class Ⅱ alleles[J]. Journal of Clinical Hepatology, 2010, 26(4): 383-386.
[20]	Xu ZhengJu, Yang Hong, Zhang QiHua, Chen XianLi, Li ShuQing, Wang ChongGuo. Study on the relationship between hepatitis B virus genotypes and effect of lamivudine therapy.[J]. Journal of Clinical Hepatology, 2005, 21(3): 157-159.

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	中国抗癌协会肿瘤消融治疗专业委员会，中国临床肿瘤学会肿瘤消融治疗专家委员会，中国医师协会介入医师分会介入围手术学组. 复合式冷热消融治疗肝肿瘤围手术期管理专家共识. 中华内科杂志. 2025(02): 110-118 .
2.	温钊，臧铁柱，宋晓改，张炫，江艳丽. 射频消融治疗包膜下与非包膜下早期肝细胞癌患者的远期预后. 河南医学研究. 2023(15): 2738-2744 .

Other cited types(0)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (421) PDF downloads(81)

Value of gallbladder-preserving partial cholecystectomy in treatment of abnormal gallbladder morphology complicated by sand-like calculous cholecystitis

DOI: 10.3969/j.issn.1001-5256.2016.10.022