Objective To investigate the risk factors for HBV-related liver cirrhosis complicated by acute upper gastrointestinal bleeding (AUGIB) .Methods A total of 58 patients with HBV-related liver cirrhosis complicated by AUGIB who were hospitalized in our hospital from January to December, 2011 were enrolled as study group, and 100 patients with HBV-related liver cirrhosis who did not experience upper gastrointestinal bleeding during the same period of time were enrolled as control group.Their general clinical data were collected.The t-test was used for comparison of continuous data between groups, the chi-square test was used for comparison of categorical data between groups, the multivariate Cox regression model was used to analyze the risk factors, and the life table method was used to analyze 1-, 2-, and 3-year cumulative survival rates and plot survival curves.Results The 1-, 2-, and 3-year cumulative survival rates in the patients with HBV-related liver cirrhosis complicated by AUGIB were 72.2%, 51.9%, and 35.2%, respectively, with a median survival time of 24.7 months.The univariate analysis showed that AUGIB was associated with bleeding history (χ2=7.128, P=0.008) , course of disease (t=8.283, P<0.001) , bad eating habits (χ2=7.612, P=0.006) , Child-Pugh class (χ2=6.045, P=0.049) , degree of esophageal varices (χ2=46.241, P<0.001) , gastric varices (χ2=14.211, P<0.001) , and portal hypertension (χ2=6.846, P=0.009) .The multivariate Cox regression analysis revealed that course of disease (RR=0.745, 95% CI:0.824-0.967, P=0.026) , bad eating habits (RR=1.426, 95% CI:1.033-2.582, P=0.032) , Child-Pugh class (RR=2.032, 95% CI:1.05-2.34, P=0.036) , degree of esophageal varices (RR=0.796, 95% CI:1.23-3.37, P=0.015) , degree of gastric varices (RR=0.825, 95% CI:2.46-3.92, P=0.043) , and portal hypertension (RR=0.983, 95% CI:1.26-3.75, P=0.007) were independent risk factors for the prognosis of patients with HBV-related liver cirrhosis complicated by AUGIB.Conclusion Course of disease, bad eating habits, Child-Pugh class, degree of esophageal varices, degree of gastric varices, and portal hypertension are independent risk factors for the prognosis of patients with HBV-related liver cirrhosis complicated by AUGIB.These factors should be taken seriously by clinical physicians to improve patients' prognosis.
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