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Volume 38 Issue 6
Jun.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(6): 1351-1355

Ultrasound findings and contrast-enhanced ultrasound findings of mass-type autoimmune pancreatitis versus pancreatic ductal adenocarcinoma

DOI: 10.3969/j.issn.1001-5256.2022.06.025
  • a.

    Department of Ultrasound, Tangshan Gongren Hospital, Tangshan, Hebei 063000, China

  • b.

    Department of Nuclear Medicine, Tangshan Gongren Hospital, Tangshan, Hebei 063000, China

  • c.

    Department of Nutrition, Tangshan Gongren Hospital, Tangshan, Hebei 063000, China

Research funding:

Science & Technology Program of Tangshan (19150220E)

More Information
  • Corresponding author: WANG Yanbin, wangyanbin689@163.com(ORCID: 0000-0001-9861-1763)
  • Received Date: 2021-11-09
  • Accepted Date: 2021-12-02
  • Published Date: 2022-06-20
    Abstract
  •   Objective  To investigate the value of ultrasound and contrast-enhanced ultrasound (CEUS) in the differential diagnosis of mass-type autoimmune pancreatitis (AIP) and pancreatic ductal adenocarcinoma (PDAC).  Methods  A retrospective analysis was performed for the clinical data, ultrasound findings, and CEUS findings of 11 patients with mass-type AIP who were diagnosed in Tangshan Workers' Hospital from January 2015 to December 2020, and their characteristic manifestations were analyzed and compared with the data of 23 patients with PDCA. The chi-square test was used for comparison of categorical data between two groups.  Results  For the 11 patients with mass-type AIP, CEUS had a diagnostic accuracy of 63.64%, and all of these patients had hypoechoic single lesions; the patients with clear boundaries, regular morphology, pancreatic duct dilatation or cutoff, and blood flow signal accounted for 54.55%, 63.64%, 18.18%, and 36.36%, respectively, while in the PDCA group, such patients accounted for 30.43%, 34.78%, 78.26%, and 21.74%, respectively, and there was a significant difference in the presence or absence of pancreatic duct dilatation or cutoff between the two groups(χ2=11.089, P < 0.05), with no significant differences in the other indices (all P > 0.05). For the 11 patients with mass-type AIP, CEUS showed that 7 patients (63.64%) had hyperenhancement and 4 (36.36%) had iso-enhancement in the arterial phase, and 5 patients (45.45%) had hyperenhancement in the arterial phase and 6 (54.55%) had iso-enhancement in the venous phase; for the 23 patients with PDCA, 22 (95.65%) had hypoenhancement of lesions in both arterial and venous phases, and there were significant differences in the enhancement pattern in arterial and venous phases between the two groups (χ2=30.345 and 30.084, both P < 0.05).  Conclusion  The enhancement pattern of CEUS and the presence or absence of pancreatic duct dilatation or cutoff have a relatively high value in the differential diagnosis of mass-type AIP and PDCA.

     

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    • References(16)
  • [1]
    GOYAL S, SAKHUJA P. Autoimmune pancreatitis: Current perspectives[J]. Indian J Pathol Microbiol, 2021, 64(Supplement): S149-S159. DOI: 10.4103/ijpm.ijpm_59_21.
    [2]
    SHIMOSEGAWA T, CHARI ST, FRULLONI L, et al. International consensus diagnostic criteria for autoimmune pancreatitis: Guidelines of the International Association of Pancreatology[J]. Pancreas, 2011, 40(3): 352-358. DOI: 10.1097/MPA.0b013e3182142fd2.
    [3]
    PODDIGHE D. Autoimmune pancreatitis and pancreatic cancer: Epidemiological aspects and immunological considerations[J]. World J Gastroenterol, 2021, 27(25): 3825-3836. DOI: 10.3748/wjg.v27.i25.3825.
    [4]
    HAGHBIN H, CHUANG J, FATIMA R, et al. Correlation of autoimmune pancreatitis and malignancy: Systematic review and Meta-analysis[J]. Dig Dis Sci, 2021. DOI: 10.1007/s10620-021-07179-9.
    [5]
    ZHANG Q, YANG DH, YU LY, et al. Clinical value of contrast-enhanced ultrasound in diagnosis of isolated autoimmune pancreatitis[J]. Chin J Ultrasound Med, 2019, 35(1): 35-38. DOI: 10.3969/j.issn.1002-0101.2019.01.013.

    张琪, 杨道辉, 于凌云, 等. 超声造影在诊断肿块型自身免疫性胰腺炎中的临床价值[J]. 中国超声医学杂志, 2019, 35(1): 35-38. DOI: 10.3969/j.issn.1002-0101.2019.01.013.
    [6]
    NAITOH I, KAMISAWA T, TANAKA A, et al. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort[J]. Dig Liver Dis, 2021, 53(10): 1308-1314. DOI: 10.1016/j.dld.2021.02.009.
    [7]
    CHEN ZK, ZHANG XJ, QIAN QF, et al. Ultrasonic features and diagnosis of autoimmune pancreatitis[J]. Chin J Med Imaging Technol, 2019, 35(2): 310-311. DOI: 10.13929/j.1003-3289.201807102.

    陈志奎, 张秀娟, 钱清富, 等. 自身免疫性胰腺炎的超声表现与诊断[J]. 中国医学影像技术, 2019, 35(2): 310-311. DOI: 10.13929/j.1003-3289.201807102.
    [8]
    ZHANG XL, YANG PP, QIAN LX. Ultrasound manifestations and characteristics analysis of IgG4-related autoimmune pancreatitis[J]. J Clin Exp Med, 2019, 18(19): 2127-2129. DOI: 10.3969/j.issn.1671-4695.2019.19.034.

    张晓丽, 杨沛沛, 钱林学. IgG4相关自身免疫性胰腺炎的超声表现及特征分析[J]. 临床和实验医学杂志, 2019, 18(19): 2127-2129. DOI: 10.3969/j.issn.1671-4695.2019.19.034.
    [9]
    MACINGA P, BAJER L, DEL CHIARO M, et al. Pancreatic cancer in patients with autoimmune pancreatitis: A scoping review[J]. Pancreatology, 2021, 21(5): 928-937. DOI: 10.1016/j.pan.2021.03.007.
    [10]
    ZHOU CX, ZHU XH, HUANG Y, et al. Value of contrast-enhance ultrasound and color doppler ultrasonography in the diagnosis of pancreatic tumors[J]. Pract J Cancer, 2017, 32(5): 841-843. DOI: 10.3969/j.issn.1001-5930.2017.05.045.

    周成香, 朱小虎, 黄杨, 等. 超声造影联合彩色多普勒超声对胰腺肿瘤的诊断价值[J]. 实用癌症杂志, 2017, 32(5): 841-843. DOI: 10.3969/j.issn.1001-5930.2017.05.045.
    [11]
    HAN YC. Comparison of ultrasonography characteristics and clinical manifestations between autoimmune pancreatitis and pancreatic cancer[J]. Clin Res Pract, 2019, 4(8): 98-99. DOI: 10.19347/j.cnki.2096-1413.201908038.

    韩玉彩. 自身免疫性胰腺炎与胰腺癌的超声特点及临床表现比较[J]. 临床医学研究与实践, 2019, 4(8): 98-99. DOI: 10.19347/j.cnki.2096-1413.201908038.
    [12]
    CONTI CB, CEREATTI F, DRAGO A, et al. Focal autoimmune pancreatitis: A simple flow chart for a challenging diagnosis[J]. Ultrasound Int Open, 2020, 6(3): E67-E75. DOI: 10.1055/a-1323-4906.
    [13]
    GAO F, DU LF. The review of ultrasound mediated micrbubble for pancreatic cancer diagnosis and treatment[J]. Chin J Ultrasonogr, 2020, 29(10): 911-915. DOI: 10.3760/cma.j.cn131148-20200514-00397.

    高峰, 杜联芳. 超声介导微泡在胰腺癌诊疗中的研究进展[J]. 中华超声影像学杂志, 2020, 29(10): 911-915. DOI: 10.3760/cma.j.cn131148-20200514-00397.
    [14]
    ZHANG LP. Differential diagnosis of pancreatic cancer and mass pancreatitis by contrast-enhanced ultrasound[J]. Modern Med Imagel Bimonthly, 2019, 28(12): 2712-2713. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYY201912062.htm

    张丽萍. 超声造影对胰腺癌与肿块型胰腺炎的鉴别诊断效果分析[J]. 现代医用影像学, 2019, 28(12): 2712-2713. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYY201912062.htm
    [15]
    WANG Y, AIDIBAI MHMT, GENG C, et al. Differential diagnostic value of pancreatic cancer and mass pancreatitis by contrast-enhanced ultrasound[J]. J Clin Ultrasound in Med, 2017, 19(8): 526-530. https://www.cnki.com.cn/Article/CJFDTOTAL-LCCY201708006.htm

    王燕, 艾迪拜·木合买提, 耿诚, 等. 超声造影对胰腺癌与肿块型胰腺炎的鉴别诊断价值[J]. 临床超声医学杂志, 2017, 19(8): 526-530. https://www.cnki.com.cn/Article/CJFDTOTAL-LCCY201708006.htm
    [16]
    XU XH, GUO WH, LI Y. Diagnostic value of EUS-EG combined with CEH-EUS in pancreatic space-occupying lesions[J]. Guangdong Med J, 2020, 41(20): 2146-2149. DOI: 10.13820/j.cnki.gdyx.20192312.

    许晓辉, 郭卫红, 李艳. 超声内镜弹性成像联合谐波造影增强超声内镜在胰腺占位性病变中的诊断价值[J]. 广东医学, 2020, 41(20): 2146-2149. DOI: 10.13820/j.cnki.gdyx.20192312.
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