Effect of the treatment modality for hepatocellular carcinoma on portal venous pressure

Bowen CHEN; Jiamin CHENG; Linzhi ZHANG; Jin LEI; Xiaoqiang GAO; Yinying LU

doi:10.3969/j.issn.1001-5256.2022.07.038

Volume 38 Issue 7

Jul. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(7): 1658-1661

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Effect of the treatment modality for hepatocellular carcinoma on portal venous pressure

DOI: 10.3969/j.issn.1001-5256.2022.07.038

Bowen CHEN^{1, 2},
Jiamin CHENG²,
Linzhi ZHANG^{2, 3},
Jin LEI^{2, 4},
Xiaoqiang GAO^{2, 4},
Yinying LU^{1, 2, 5
,
,
,}

1.
Peking University 302 Clinical Medical School, Beijing 100039, China
2.
Senior Department of Hepatology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
3.
Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
4.
Guizhou Medical University Clinical Medical School, Guiyang 550004, China
5.
Guangdong Key Laboratory of Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, China

Research funding:

Special Program of Sustainable Development Issued by the Science, Technology and Innovation Commission of Shenzhen Municipality (KCXFZ202002011006448)

More Information

Corresponding author: LU Yinying, luyinying1973@163.com(ORCID: 0000-0002-7737-2334)
Received Date: 2021-12-13
Accepted Date: 2022-01-27
Published Date: 2022-07-20

Abstract

Abstract

Portal hypertension (PH) on the basis of liver cirrhosis is a common complication of hepatocellular carcinoma (HCC), and it is also a key factor affecting treatment decisions and prognosis. Different treatment modalities for HCC may have different effects on portal venous pressure. Through a literature review, it is concluded that hepatectomy, repeated transcatheter arterial chemoembolization, oxaliplatin chemotherapy, and lenvatinib can lead to the increase in portal venous pressure, while sorafenib and regorafenib have been proved to reduce portal venous pressure within a short term in clinical trials and/or animal experiments. There are also reports on the effect of novel combination treatment regimens (such as atezolizumab combined with bevacizumab) and newly marketed first-line or second-line targeted drugs for HCC (such as donafenib, apatinib, and anlotinib) on portal hypertension-related complications including gastrointestinal bleeding in related clinical trials, but further studies are needed to investigate their overall effect on portal venous pressure.
- Carcinoma, Hepatocellular,
- Antineoplastic Protocols,
- Portal Pressure

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References(37)

References

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Effect of the treatment modality for hepatocellular carcinoma on portal venous pressure

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