中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

Influencing factors for the functional cure of chronic hepatitis B and related mechanism

DOI: 10.3969/j.issn.1001-5256.2022.08.004
More Information
  • Corresponding author: ZHANG Jiming, jmzhang@fudan.edu.cn(ORCID: 0000-0001-5820-950X)
  • Received Date: 2022-06-30
  • Accepted Date: 2022-07-31
  • Published Date: 2022-08-20
  • Functional cure of chronic hepatitis B (CHB), defined as negative hepatitis B surface antigen (HBsAg) with or without the presence of hepatitis B surface antibody (anti-HBs), is considered the optimal endpoint for CHB treatment at present. Studies have shown that HBsAg clearance can reduce the risk of HBV complications such as liver cirrhosis and hepatocellular carcinoma. However, HBsAg clearance rate remains at a relatively low level, which may be associated with the immune tolerance state caused by HBV infection. HBsAg clearance and/or the presence of anti-HBs indicate the partial recovery of HBV-specific immunity. This article discusses the influencing factors for the functional cure of CHB and the underlying mechanisms.

     

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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 5.8 %其他: 5.8 %其他: 1.5 %其他: 1.5 %Greece: 0.4 %Greece: 0.4 %India: 0.3 %India: 0.3 %Russian Federation: 0.1 %Russian Federation: 0.1 %United States: 0.4 %United States: 0.4 %[]: 0.5 %[]: 0.5 %上海: 3.3 %上海: 3.3 %东莞: 0.2 %东莞: 0.2 %中山: 0.1 %中山: 0.1 %乌鲁木齐: 0.4 %乌鲁木齐: 0.4 %保定: 0.2 %保定: 0.2 %包头: 0.1 %包头: 0.1 %北京: 4.3 %北京: 4.3 %十堰: 0.1 %十堰: 0.1 %南京: 0.6 %南京: 0.6 %南充: 0.4 %南充: 0.4 %南宁: 0.3 %南宁: 0.3 %南阳: 0.1 %南阳: 0.1 %卡纳塔克: 0.5 %卡纳塔克: 0.5 %印度中央邦: 0.3 %印度中央邦: 0.3 %厦门: 0.2 %厦门: 0.2 %台州: 0.4 %台州: 0.4 %合肥: 0.1 %合肥: 0.1 %吉林: 0.4 %吉林: 0.4 %哈密: 0.1 %哈密: 0.1 %哥伦布: 0.1 %哥伦布: 0.1 %大连: 1.4 %大连: 1.4 %天津: 1.7 %天津: 1.7 %宁波: 0.6 %宁波: 0.6 %安康: 0.4 %安康: 0.4 %宜昌: 0.1 %宜昌: 0.1 %密蘇里城: 0.2 %密蘇里城: 0.2 %常德: 0.1 %常德: 0.1 %广州: 2.6 %广州: 2.6 %弗吉尼亚州: 0.1 %弗吉尼亚州: 0.1 %张家口: 2.2 %张家口: 2.2 %意法半: 0.1 %意法半: 0.1 %成都: 0.8 %成都: 0.8 %新乡: 0.2 %新乡: 0.2 %新加坡: 0.1 %新加坡: 0.1 %昆明: 1.1 %昆明: 1.1 %晋城: 0.2 %晋城: 0.2 %杭州: 2.0 %杭州: 2.0 %桂林: 0.3 %桂林: 0.3 %武汉: 0.7 %武汉: 0.7 %江门: 0.1 %江门: 0.1 %济南: 0.4 %济南: 0.4 %海得拉巴: 0.2 %海得拉巴: 0.2 %深圳: 0.2 %深圳: 0.2 %温州: 0.2 %温州: 0.2 %湖州: 0.5 %湖州: 0.5 %湘潭: 0.1 %湘潭: 0.1 %漯河: 0.2 %漯河: 0.2 %濮阳: 0.1 %濮阳: 0.1 %烟台: 0.1 %烟台: 0.1 %眉山: 0.1 %眉山: 0.1 %石家庄: 0.3 %石家庄: 0.3 %福州: 0.2 %福州: 0.2 %绍兴: 0.1 %绍兴: 0.1 %耶拿: 0.2 %耶拿: 0.2 %芒廷维尤: 38.8 %芒廷维尤: 38.8 %芝加哥: 0.2 %芝加哥: 0.2 %莫斯科: 1.5 %莫斯科: 1.5 %衡水: 0.3 %衡水: 0.3 %衢州: 0.2 %衢州: 0.2 %西宁: 14.4 %西宁: 14.4 %西安: 0.3 %西安: 0.3 %贵阳: 0.1 %贵阳: 0.1 %赣州: 0.4 %赣州: 0.4 %赤峰: 0.1 %赤峰: 0.1 %运城: 1.5 %运城: 1.5 %邯郸: 0.1 %邯郸: 0.1 %重庆: 0.4 %重庆: 0.4 %长春: 0.9 %长春: 0.9 %长沙: 0.9 %长沙: 0.9 %香港: 0.2 %香港: 0.2 %其他其他GreeceIndiaRussian FederationUnited States[]上海东莞中山乌鲁木齐保定包头北京十堰南京南充南宁南阳卡纳塔克印度中央邦厦门台州合肥吉林哈密哥伦布大连天津宁波安康宜昌密蘇里城常德广州弗吉尼亚州张家口意法半成都新乡新加坡昆明晋城杭州桂林武汉江门济南海得拉巴深圳温州湖州湘潭漯河濮阳烟台眉山石家庄福州绍兴耶拿芒廷维尤芝加哥莫斯科衡水衢州西宁西安贵阳赣州赤峰运城邯郸重庆长春长沙香港

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