Acute humoral rejection in liver xenotransplantation

Zhongqiang ZHANG; Shuozhou LIANG; Zhongzhou SI; Haizhi QI

doi:10.3969/j.issn.1001-5256.2022.10.003

Volume 38 Issue 10

Oct. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(10): 2210-2213

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Acute humoral rejection in liver xenotransplantation

DOI: 10.3969/j.issn.1001-5256.2022.10.003

Zhongqiang ZHANG^{1, 2},
Shuozhou LIANG^{1, 2},
Zhongzhou SI^{1, 2
,
,
,},
Haizhi QI^{1, 2}

1.
Department of Liver Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China
2.
Transplant Medicine Research Center, The Second Xiangya Hospital of Central South University, Changsha 410011, China

Research funding:

Hunan Provincial Key Research Project (2021DK2002)

More Information

Corresponding author: SI Zhongzhou, zhongzsi@csu.edu.cn(ORCID: 0000-0022-8875-9651)
Received Date: 2020-07-30
Accepted Date: 2020-08-31
Published Date: 2022-10-20

Abstract

Abstract

Liver transplantation is a curable therapy to save the life of patients with end-stage liver diseases of different causes. The serious shortage of liver donors led to the death of a large number of patients with end-stage liver disease. Genetic-engineered pigs used for xenotransplantation are one of the potential solutions to alleviate the liver donor shortage, but currently clinical application of such xenogeneic liver grafts is hindered by acute rejection, thrombocytopenia, and coagulation dysfunctions in patients. The development of genetic-engineering technology and the application of new immunosuppressants have controlled the acute rejection of liver xenotransplantation to some extent. However, acute humoral rejection may become another major issue for the long-term graft failure. This review summarized and discussed the potential and underlying mechanisms and preventive measures of acute humoral rejection in liver xenotransplantation.
- Liver Transplantation,
- Transplantation, Heterologous,
- Animals, Genetically Modified,
- Graft Rejection

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References

[1]	BALJER BC, KOLHE S, CHAN CD, et al. Advances in image enhancement for sarcoma surgery[J]. Cancer Lett, 2020, 483: 1-11. DOI: 10.1016/j.canlet.2020.03.029.
[2]	MEIRELLES JÚNIOR RF, SALVALAGGIO P, REZENDE MB, et al. Liver transplantation: history, outcomes and perspectives[J]. Einstein (Sao Paulo), 2015, 13(1): 149-152. DOI: 10.1590/S1679-45082015RW3164.
[3]	COOPER D, WIJKSTROM M, HARIHARAN S, et al. Selection of patients for initial clinical trials of solid organ xenotransplantation[J]. Transplantation, 2017, 101(7): 1551-1558. DOI: 10.1097/TP.0000000000001582.
[4]	ZHANG X, LI X, YANG Z, et al. A review of pig liver xenotransplantation: Current problems and recent progress[J]. Xenotransplantation, 2019, 26(3): e12497. DOI: 10.1111/xen.12497.
[5]	van der Heyde MN. Liver transplantation[J]. Ned Tijdschr Geneeskd, 1968, 112(41): 1823-1827.
[6]	WOLF P, MEYER C, BOUDJEMA K, et al. The pig as a model in liver xenotransplantation[J]. Vet Res, 1997, 28(3): 217-222.
[7]	EKSER B, GRIDELLI B, TECTOR AJ, et al. Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit?[J]. Transplantation, 2009, 88(9): 1041-1049. DOI: 10.1097/TP.0b013e3181ba0555.
[8]	PATEL MS, LOURAS N, VAGEFI PA. Liver xenotransplantation[J]. Curr Opin Organ Transplant, 2017, 22(6): 535-540. DOI: 10.1097/MOT.0000000000000459.
[9]	CIMENO A, BARTH RN, LAMATTINA JC. Advances in liver xenotransplantation[J]. Curr Opin Organ Transplant, 2018, 23(6): 615-620. DOI: 10.1097/MOT.0000000000000578.
[10]	RAMIREZ P, CHAVEZ R, MAJADO M, et al. The porcine liver supports metabolic homeostasis in the nonhuman primate: experimental study in a model of orthotopic liver transplantation from h-DAF transgenic pig to baboon[J]. Transplant Proc, 2000, 32(5): 1112-1113. DOI: 10.1016/s0041-1345(00)01150-7.
[11]	EKSER B, LONG C, ECHEVERRI GJ, et al. Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance[J]. Am J Transplant, 2010, 10(2): 273-285. DOI: 10.1111/j.1600-6143.2009.02945.x.
[12]	KIM K, SCHUETZ C, ELIAS N, et al. Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons[J]. Xenotransplantation, 2012, 19(4): 256-264. DOI: 10.1111/j.1399-3089.2012.00717.x.
[13]	DOU K, WANG D, TAO K, et al. A modified heterotopic auxiliary living donor liver transplantation: report of a case[J]. Ann Hepatol, 2014, 13(3): 399-403. DOI: 10.1016/S1665-2681(19)30872-5
[14]	YEH H, MACHAIDZE Z, WAMALA I, et al. Increased transfusion-free survival following auxiliary pig liver xenotransplantation[J]. Xenotransplantation, 2014, 21(5): 454-464. DOI: 10.1111/xen.12111.
[15]	NAVARRO-ALVAREZ N, SHAH JA, ZHU A, et al. The effects of exogenous administration of human coagulation factors following pig-to-baboon liver xenotransplantation[J]. Am J Transplant, 2016, 16(6): 1715-1725. DOI: 10.1111/ajt.13647.
[16]	SHAH JA, NAVARRO-ALVAREZ N, DEFAZIO M, et al. A bridge to somewhere: 25-day survival after pig-to-baboon liver xenotransplantation[J]. Ann Surg, 2016, 263(6): 1069-1071. DOI: 10.1097/SLA.0000000000001659.
[17]	SHAH JA, PATEL MS, ELIAS N, et al. Prolonged survival following pig-to-primate liver xenotransplantation utilizing exogenous coagulation factors and costimulation blockade[J]. Am J Transplant, 2017, 17(8): 2178-2185. DOI: 10.1111/ajt.14341.
[18]	LI X, WANG Y, YANG H, et al. Liver and hepatocyte transplantation: what can pigs contribute?[J]. Front Immunol, 2021, 12: 802692. DOI: 10.3389/fimmu.2021.802692.
[19]	YANG YG, SYKES M. Xenotransplantation: current status and a perspective on the future[J]. Nat Rev Immunol, 2007, 7(7): 519-531. DOI: 10.1038/nri2099.
[20]	ZHOU Q, LI T, WANG K, et al. Current status of xenotransplantation research and the strategies for preventing xenograft rejection[J]. Front Immunol, 2022, 13: 928173. DOI: 10.3389/fimmu.2022.928173.
[21]	EKSER B, KLEIN E, HE J, et al. Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs[J]. PLoS One, 2012, 7(1): e29720. DOI: 10.1371/journal.pone.0029720.
[22]	COOPER D, EKSER B, TECTOR AJ. Immunobiological barriers to xenotransplantation[J]. Int J Surg, 2015, 23(Pt B): 211-216. DOI: 10.1016/j.ijsu.2015.06.068.
[23]	CHEN G, QIAN H, STARZL T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys[J]. Nat Med, 2005, 11(12): 1295-1298. DOI: 10.1038/nm1330.
[24]	ZHU A, HURST R. Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum[J]. Xenotransplantation, 2002, 9(6): 376-381. DOI: 10.1034/j.1399-3089.2002.02138.x.
[25]	COOPER DK. Modifying the sugar icing on the transplantation cake[J]. Glycobiology, 2016, 26(6): 571-581. DOI: 10.1093/glycob/cww028.
[26]	WANG RG, RUAN M, ZHANG RJ, et al. Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigs[J]. J Biomed Res, 2018. DOI: 10.7555/JBR.32.20180018.[Online ahead of print]
[27]	Humoral reactivity of renal transplant-waitlisted patients to cells from ggta1/cmah/b4galnt2, and sla class i knockout pigs: erratum[J]. Transplantation, 2018, 102(2): e88. DOI: 10.1097/TP.0000000000002066.
[28]	LADOWSKI JM, HARA H, COOPER D. The role of slas in xenotransplantation[J]. Transplantation, 2021, 105(2): 300-307. DOI: 10.1097/TP.0000000000003303.
[29]	EKSER B, BURLAK C, WALDMAN JP, et al. Immunobiology of liver xenotransplantation[J]. Expert Rev Clin Immunol, 2012, 8(7): 621-634. DOI: 10.1586/eci.12.56.
[30]	CANDINAS D, BELLIVEAU S, KOYAMADA N, et al. T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection[J]. Transplantation, 1996, 62(12): 1920-1927. DOI: 10.1097/00007890-199612270-00042.
[31]	FOX A, MOUNTFORD J, BRAAKHUIS A, et al. Innate and adaptive immune responses to nonvascular xenografts: evidence that macrophages are direct effectors of xenograft rejection[J]. J Immunol, 2001, 166(3): 2133-2140. DOI: 10.4049/jimmunol.166.3.2133.
[32]	HAUZENBERGER E, KLOMINEK J, HOLGERSSON J. Anti-Gal IgG potentiates natural killer cell migration across porcine endothelium via endothelial cell activation and increased natural killer cell motility triggered by CD16 cross-linking[J]. Eur J Immunol, 2004, 34(4): 1154-1163. DOI: 10.1002/eji.200324568.
[33]	LI S, YAN Y, LIN Y, et al. Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells[J]. Blood, 2007, 110(12): 3926-3935. DOI: 10.1182/blood-2007-01-065482.
[34]	EZZELARAB M, GARCIA B, AZIMZADEH A, et al. The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients[J]. Transplantation, 2009, 87(6): 805-812. DOI: 10.1097/TP.0b013e318199c34f.
[35]	AL-MOHANNA FA, COLLISON KS, ALLEN SP, et al. Naive neutrophils and xenotransplantation[J]. Lancet, 1996, 348(9036): 1246. DOI: 10.1016/S0140-6736(05)65524-9.
[36]	ZHANG X, WANG Q, ZHAO J, et al. The resurgent landscape of xenotransplantation of pig organs in nonhuman primates[J]. Sci China Life Sci, 2021, 64(5): 697-708. DOI: 10.1007/s11427-019-1806-2.
[37]	RAMIREZ P, MONTOYA MJ, RIOS A, et al. Prevention of hyperacute rejection in a model of orthotopic liver xenotransplantation from pig to baboon using polytransgenic pig livers (CD55, CD59, and H-transferase)[J]. Transplant Proc, 2005, 37(9): 4103-4106. DOI: 10.1016/j.transproceed.2005.09.186.

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Acute humoral rejection in liver xenotransplantation

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