Clinical features of patients with malignant tumor-related pyogenic liver abscess

Gufen ZHANG; Na YAO; Mingyuan BI; Ye ZHANG; Wen KANG; Jianqi LIAN; Linxu WANG; Chunfu WANG

doi:10.3969/j.issn.1001-5256.2023.04.016

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 850-855

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Clinical features of patients with malignant tumor-related pyogenic liver abscess

DOI: 10.3969/j.issn.1001-5256.2023.04.016

Department of Infectious Diseases, The Second Affiliated of Air Force Medical University, Xi'an 710038, China

Research funding:

Shaanxi Provincial Key Research and Development Program (2022SF-186)

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Corresponding author: WANG Chunfu, wcf402@163.com (ORCID: 0000-0003-0879-3933)
Received Date: 2022-09-08
Accepted Date: 2022-10-17
Published Date: 2023-04-20

Abstract

Abstract

Objective To investigate the clinical features of malignant tumor-related pyogenic liver abscess (PLA), and to provide a basis for early judgment of disease progression and timely and effective treatment. Methods A retrospective analysis was performed for the clinical data of 371 patients with PLA who were admitted to the Second Affiliated of Air Force Medical University, from March 2005 to July 2018, among whom 34 patients with malignant tumor-related PLA were enrolled as tumor group, and after matching for time and at a ratio of 1∶2, 70 patients without malignant tumor-related PLA were enrolled as non-tumor group. Clinical features were compared between the two groups. The group t-test was used for comparison of normally distributed continuous data between groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups; the chi-square test or the Fisher's exact test was used for comparison of categorical data between groups. Results In the tumor group, there were 22 patients with hepatobiliary tumor (64.7%), 7 patients with gastrointestinal tumor (20.6%), and 5 patients with non-gastrointestinal tumor (14.7%). Compared with the non-tumor group, the tumor group had a significantly higher proportion of patients with a history of abdominal surgery (44.1% vs 7.1%, χ²=20.142, P < 0.05), liver cirrhosis (26.5% vs 7.1%, χ²=7.338, P < 0.05), or an Acute Physiology and Chronic Health Evaluation Ⅱ score of > 16 (44.1% vs 15.7%, χ²=9.846, P=0.002). Compared with the non-tumor group in terms of laboratory examination, the tumor group had a significantly lower level of albumin [(27.2±5.2) g/L vs (30.8±2.6) g/L, t=-3.131, P=0.002] and a significantly higher level of total bilirubin [54(13~313) μmol/L vs 33(7~96) μmol/L, U=1 816.0, P < 0.001]. Escherichia coli was the main pathogen in the tumor group (23.5%), while Klebsiella pneumonia was the main pathogen in the non-tumor group (23.5%), and compared with the non-tumor group, the tumor group had a significantly higher proportion of patients infected with more than two types of bacteria (11.8% vs 2.8%). Radiological examination showed that the tumor group had a significantly higher proportion of patients with multiple abscesses than the non-tumor group (47.1% vs 24.3%, χ²=5.479, P=0.019). Compared with the non-tumor group, the tumor group had a significantly longer mean length of hospital stay (U=1 728.5, P < 0.001) and a significantly higher treatment failure rate (P=0.005). Conclusion Patients with malignant tumor-related PLA often have hepatobiliary tumor, with Escherichia coli as the main pathogen. Abscesses at multiple sites are common, and patients tend to have a poor prognosis. Appropriate antibiotics combined with percutaneous drainage should be used in clinical practice, and for the high-risk population, the threshold for surgical intervention can be lowered to reduce mortality.
- Liver Abscess,
- Neoplasms,
- Prognosis

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References

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Clinical features of patients with malignant tumor-related pyogenic liver abscess

DOI: 10.3969/j.issn.1001-5256.2023.04.016