Value of atherogenic index of plasma combined with Bedside Index for Severity in Acute Pancreatitis in the early prediction of severe hypertriglyceridemic acute pancreatitis

Qi JI; Xi HUANG; Chenyi SHE; Song ZHANG; Weitian XU; Qingming WU

doi:10.3969/j.issn.1001-5256.2023.06.021

Volume 39 Issue 6

Jun. 2023

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2023 > 39(6): 1398-1403

PDF( 2004 KB)

Value of atherogenic index of plasma combined with Bedside Index for Severity in Acute Pancreatitis in the early prediction of severe hypertriglyceridemic acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2023.06.021

1.
Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
2.
Department of Gastroenterology, The General Hospital of Central Theater Command, Wuhan 430070, China

Research funding:

National Natural Science Foundation of China (82200708);

Natural Science Foundation of Hubei Province (2021CFB001)

More Information

Corresponding author: WU Qingming, wuhe9224@sina.com (ORCID: 0000-0002-8009-1867)
Received Date: 2022-10-31
Accepted Date: 2022-12-05
Published Date: 2023-06-20

Abstract

Abstract

Objective To investigate the correlation between atherogenic index of plasma (AIP) and the severity of hypertriglyceridemic acute pancreatitis (HTG-AP) and the value of AIP combined with Bedside Index for Severity in Acute Pancreatitis (BISAP) score in the early prediction of severe HTG-AP (sHTG-AP). Methods A retrospective analysis was performed for the clinical data of 170 patients with HTG-AP who were hospitalized in The General Hospital of Central Theater Command from January 2017 to December 2021, and according to related guidelines, they were divided into the sHTG-AP group with 28 patients and non-sHTG-AP group with 142 patients. Peripheral blood samples were collected from all patients within 24 hours after admission, and the two groups were compared in terms of sex, age, laboratory test results, AIP, BISAP score, and modified CT severity index (MCTSI) score. The chi-square test or the Fisher's exact test was used for comparison of categorical data between groups; the Mann-Whitney U test was used for comparison of continuous data between groups. The Spearman rank correlation test was used to investigate the correlation between each factor and the severity of HTG-AP, and the binary logistic regression analysis were used to investigate the independent risk factors for sHTG-AP. The receiver operating characteristic (ROC) curve was plotted to assess the predictive efficacy of each indicator. Results There were significant differences between the two groups in the medical history of diabetes, lymphocyte count, albumin, Ca²⁺, triglyceride, high-density lipoprotein cholesterol, AIP, BISAP score, MCTSI score, length of hospital stay, and hospital costs (all P < 0.05). The sHTG-AP group had a longer length of hospital stay, higher hospital costs, and a higher AIP value. AIP (odds ratio [OR]=1.244, 95% confidence interval [CI]: 1.062-1.458, P=0.007), BISAP score (OR=5.525, 95%CI: 1.646-18.543, P=0.006), and MCTSI score (OR=2.029, 95%CI: 1.245-3.305, P=0.004) were risk factors for sHTG-AP. AIP, BISAP score, and MCTSI score were positively correlated with the severity of HTG-AP (r=0.291, 0.631, and 0.649, all P < 0.001), and AIP was positively correlated with BISAP score and MCTSI score (r=0.190 and 0.215, both P < 0.05). AIP had an optimal cut-off value of 1.095 in predicting sHTG-AP, and AIP, BISAP score, and AIP combined with BISAP score had an area under the ROC curve of 0.759, 0.887, 0.925, respectively, a sensitivity of 0.821, 0.857, and 0.786, respectively, and a specificity of 0.627, 0.817, and 0.937, respectively (all P < 0.001). Conclusion AIP is a risk factor for sHTG-AP and is correlated with disease severity, and AIP combined with BISAP score has a relatively high value in the early prediction of sHTG-AP.
- Atherogenic Index of Plasma,
- Pancreatitis,
- Hypertriglyceridemia

FullText(HTML)

References(17)

References

[1]	PU W, LUO G, CHEN T, et al. A 5-year retrospective cohort study: Epidemiology, etiology, severity, and outcomes of acute pancreatitis[J]. Pancreas, 2020, 49(9): 1161-1167. DOI: 10.1097/MPA.0000000000001637.
[2]	WU H, MA K, LIAO B, et al. Comparative analysis of early clinical features and complications of different types of acute pancreatitis[J]. Oxid Med Cell Longev, 2022, 2022: 3771610. DOI: 10.1155/2022/3771610.
[3]	LIU SZ, YAO JR, MO SJ, et al. Research progress of nutritional support in severe acute pancreatitis[J/OL]. Chin J Hepat Surg(Electronic Edition), 2021, 10(5): 533-535. DOI: 10.3877/cma.j.issn.2095-3232.2021.05.022. 刘世洲, 姚佳柔, 莫绍剑, 等. 重症急性胰腺炎营养支持研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2021, 10(5): 533-535. DOI: 10.3877/cma.j.issn.2095-3232.2021.05.022.
[4]	DOBIÁSOVÁ M, FROHLICH J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL))[J]. Clin Biochem, 2001, 34(7): 583-588. DOI: 10.1016/s0009-9120(01)00263-6.
[5]	CHO SK, KIM JW, HUH JH, et al. Atherogenic index of plasma is a potential biomarker for severe acute pancreatitis: a prospective observational study[J]. J Clin Med, 2020, 9(9): 2982. DOI: 10.3390/jcm9092982.
[6]	WANG Q, WANG G, QIU Z, et al. Elevated serum triglycerides in the prognostic assessment of acute pancreatitis: a systematic review and meta-analysis of observational studies[J]. J Clin Gastroenterol, 2017, 51(7): 586-593. DOI: 10.1097/MCG.0000000000000846.
[7]	SU W, GUO F. Triglyceride-controlling during acute phase of hypertriglyceridemia induced pancreatitis[J]. Chin J Dig Surg, 2023, 22(1): 89-93. DOI: 10.3760/cma.j.cn115610-20221220-00755. 苏伟, 郭丰. 高甘油三酯血症性胰腺炎急性期的血脂控制[J]. 中华消化外科杂志, 2023, 22(1): 89-93. DOI: 10.3760/cma.j.cn115610-20221220-00755.
[8]	HANSEN S, MADSEN CM, VARBO A, et al. Low-grade inflammation in the association between mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis: a study of more than 115000 individuals from the general population[J]. Clin Chem, 2019, 65(2): 321-332. DOI: 10.1373/clinchem.2018.294926.
[9]	DONG X, PAN S, ZHANG D, et al. Hyperlipemia pancreatitis onset time affects the association between elevated serum triglyceride levels and disease severity[J]. Lipids Health Dis, 2022, 21(1): 49. DOI: 10.1186/s12944-022-01656-4.
[10]	ZHANG Y, GUO F, LI S, et al. Decreased high density lipoprotein cholesterol is an independent predictor for persistent organ failure, pancreatic necrosis and mortality in acute pancreatitis[J]. Sci Rep, 2017, 7(1): 8064. DOI: 10.1038/s41598-017-06618-w.
[11]	LI YJ, LI J. The value of red blood cell distribution width to platelet ratio and C-reactive protein to albumin ratio combined with BISAP scores in the assessment of acute pancreatitis[J]. Chin J Emerg Med, 2022, 31(9): 1200-1205. DOI: 10.3760/cma.j.issn.1671-0282.2022.09.008. 李艳杰, 李静. 红细胞分布宽度/血小板计数、C反应蛋白/白蛋白联合BISAP评分对急性胰腺炎病情评估的价值[J]. 中华急诊医学杂志, 2022, 31(9): 1200-1205. DOI: 10.3760/cma.j.issn.1671-0282.2022.09.008.
[12]	DONG BY, MAO YQ, LI ZY, et al. The value of the atherogenic index of plasma in non-obese people with non-alcoholic fatty liver disease: a secondary analysis based on a cross-sectional study[J]. Lipids Health Dis, 2020, 19(1): 148. DOI: 10.1186/s12944-020-01319-2.
[13]	LI YW, KAO TW, CHANG PK, et al. Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study[J]. Sci Rep, 2021, 11(1): 9900. DOI: 10.1038/s41598-021-89307-z.
[14]	WON KB, HEO R, PARK HB, et al. Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors[J]. Atherosclerosis, 2021, 324: 46-51. DOI: 10.1016/j.atherosclerosis.2021.03.009.
[15]	LI X, GUO X, JI H, et al. Relationships between metabolic comorbidities and occurrence, severity, and outcomes in patients with acute pancreatitis: a narrative review[J]. Biomed Res Int, 2019, 2019: 2645926. DOI: 10.1155/2019/2645926.
[16]	HUANG HM, YANG HY, QIN YY, et al. Relationship between visceral fat related index and the severity of acute pancreatitis[J]. J Clin Hepatol, 2022, 38(10): 2313-2319. DOI: 10.3969/j.issn.1001-5256.2022.10.021. 黄河铭, 杨慧莹, 覃颖颖, 等. 内脏脂肪相关指数与急性胰腺炎严重程度的关系[J]. 临床肝胆病杂志, 2022, 38(10): 2313-2319. DOI: 10.3969/j.issn.1001-5256.2022.10.021.
[17]	SONG XJ, GAO WB, ZHU JH. The prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio combined with BISAP score for severe hypertriglyceridemia pancreatitis[J]. Chin J Emerg Med, 2022, 31(9): 1193-1199. DOI: 10.3760/cma.j.issn.1671-0282.2022.09.007. 宋小静, 高伟波, 朱继红. 中性粒/淋巴细胞比率、血小板/淋巴细胞比率联合BISAP评分对于重症高三酰甘油血症性胰腺炎早期预测分析[J]. 中华急诊医学杂志, 2022, 31(9): 1193-1199. DOI: 10.3760/cma.j.issn.1671-0282.2022.09.007.

Relative Articles

[1]	Long HAI, Lina MA, Xia LUO, Xiangchun DING. Effect of miRNA-933 on the apoptosis and proliferation of LX-2 cells and its molecular mechanism[J]. Journal of Clinical Hepatology, 2024, 40(7): 1382-1389. doi: 10.12449/JCH240716
[2]	Yao ZHANG, Kai ZHANG, Pengdong KANG, Chao MA. Research advances in microRNA-200c in pancreatic cancer[J]. Journal of Clinical Hepatology, 2022, 38(4): 961-964. doi: 10.3969/j.issn.1001-5256.2022.04.045
[3]	Sheng CHEN, Guoxiang CHEN, Zhongming HE, Shujie CHENG, Jisen ZHAO. Role of miRNA in the development and progression of cholangiocarcinoma[J]. Journal of Clinical Hepatology, 2021, 37(9): 2241-2245. doi: 10.3969/j.issn.1001-5256.2021.09.048
[4]	Huijun XIE, Nasot Rashed, Yong NING, Chuan GAO. Current status of research on circulating microRNAs as diagnostic markers for hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(2): 448-451. doi: 10.3969/j.issn.1001-5256.2021.02.042
[5]	Xuemei DING, Shilun WU, Wenbing SUN. Value of preoperative microRNA-192 in peripheral blood mononuclear cells in predicting microvascular invasion of solitary hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(5): 1121-1125. doi: 10.3969/j.issn.1001-5256.2021.05.028
[6]	Xiuhong HUANG, Xiaoli XIE, Huiqing JIANG. Value of a microRNA risk score model in predicting the prognosis of hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(5): 1110-1115. doi: 10.3969/j.issn.1001-5256.2021.05.026
[7]	Wu Jie, Li JingTao, Wei HaiLiang, Yan ShuGuang, Fan Yu, Guo YingJun, Chang ZhanJie. Advances in the role of microRNA in the intervention of malignant transformation of precancerous lesions of the liver by regulating the activation of hepatic stellate cells[J]. Journal of Clinical Hepatology, 2020, 36(7): 1650-1654. doi: 10.3969/j.issn.1001-5256.2020.07.045
[8]	Guo Xuan, Tan Wei, Wang ChangJun. Mechanism of action of circular RNAs in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2020, 36(10): 2340-2343. doi: 10.3969/j.issn.1001-5256.2020.10.039
[9]	Cheng YaFei, Wang Bin, Wang ShiMing. Role of microRNAs in gallbladder carcinoma[J]. Journal of Clinical Hepatology, 2020, 36(8): 1900-1904. doi: 10.3969/j.issn.1001-5256.2020.08.049
[10]	Wang ZeXin, Guan LiJun, Li JianMing, Wang ZhiChao, Xue MengRuo, Qin XiaoJun. Effect of targeted regulation of the Wnt2 gene by microRNA( microRNA-21) on the proliferation and migration of HepG2 hepatoma cells[J]. Journal of Clinical Hepatology, 2020, 36(4): 803-807. doi: 10.3969/j.issn.1001-5256.2020.04.019
[11]	Wu JunYi, Lai ZhiDe, Tian YiFeng, Wang YaoDong. Expression and clinical significance of serum exosomal microRNA-221-3p in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2020, 36(8): 1768-1772. doi: 10.3969/j.issn.1001-5256.2020.08.018
[12]	Huang XiangJun, Zhang WenXing. Expression features and clinical significance of the microRNA-888 gene family in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2019, 35(1): 119-122. doi: 10.3969/j.issn.1001-5256.2019.01.022
[13]	Niu YaQian, Chang YuLing, Liu Fang, Zhao Chuan, Chen Che. Regulatory role of microRNA in aerobic glycolysis in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2019, 35(9): 2082-2084. doi: 10.3969/j.issn.1001-5256.2019.09.044
[14]	Zhang ZhuQing, Lu ShuMing, Wang HuaLi, Xu MengYao, Li ChunYan, Xin Yue, Zhao JunJun. Expression of microRNA-222 in hepatocellular carcinoma tissue and its clinical significance[J]. Journal of Clinical Hepatology, 2017, 33(8): 1502-1505. doi: 10.3969/j.issn.1001-5256.2017.08.018
[15]	Wang DongXu, Huo TingTing, Tian YaoWen, Zhao Lei. Current status of research on microRNA associated with colorectal cancer liver metastasis[J]. Journal of Clinical Hepatology, 2016, 32(12): 2387-2390. doi: 10.3969/j.issn.1001-5256.2016.12.034
[16]	Qiu Hua, Sun XueHua, Zhou ZhenHua, Li Man, Zhang Xin, Gao YueQiu. Influence of interaction between endogenous miRNAs and hepatitis B virus in hepatocytes on hepatitis B virus transcription and related mechanisms[J]. Journal of Clinical Hepatology, 2016, 32(11): 2186-2190. doi: 10.3969/j.issn.1001-5256.2016.11.042
[17]	Xiao ZuoHan, Meng Gang, Wang LiZhi, Sun WenJin. Diagnostic value of combined determination of DNA ploidy level and miRNA-21 expression in ascites cells for hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2015, 31(1): 93-98. doi: 10.3969/j.issn.1001-5256.2015.01.020
[18]	Li Qiang, Zhuo QiBin, Huang YuXian, Chen Liang. Diagnosis and treatment of hepatocellular carcinoma from a new perspective of miRNAs[J]. Journal of Clinical Hepatology, 2015, 31(6): 977-981. doi: 10.3969/j.issn.1001-5256.2015.06.037
[19]	Qu YaChao, LYU Jun. Research progress in serum microRNA detection for diagnosis of hepatocellular carcinoma [J]. Journal of Clinical Hepatology, 2014, 30(3): 228-232. doi: 10.3969/j.issn.1001-5256.2014.03.008
[20]	Guo JinSheng. Recent perspectives on mechanisms of liver fibrogenesis: microRNA and cell autophagy [J]. Journal of Clinical Hepatology, 2013, 29(5): 324-326.

Supplements(0)

Cited By

Cited by

Periodical cited type(1)

孙巍，丁晓燕，陈京龙，李文东，郭晓笛，申燕军，滕颖，刘晓民，魏建莹. MicroRNA-520a通过失活AKT抑制HepG2.2.15细胞中HBV DNA复制. 中国肝脏病杂志(电子版). 2018(04): 73-78 .

Other cited types(0)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (491) PDF downloads(39)

Value of atherogenic index of plasma combined with Bedside Index for Severity in Acute Pancreatitis in the early prediction of severe hypertriglyceridemic acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2023.06.021