Role of intestinal microbiota and metabolites in the development, progression, and treatment of nonalcoholic fatty liver disease

Yongqiang LI; Wenjuan TANG; Yongjian ZHOU

doi:10.3969/j.issn.1001-5256.2023.08.006

Volume 39 Issue 8

Aug. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(8): 1805-1810

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Role of intestinal microbiota and metabolites in the development, progression, and treatment of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2023.08.006

Department of Gastroenterology, Guangzhou First People's Hospital & The Second Affiliated Hospital of South China University of Technology; Guangzhou Digestive Disease Center, Guangzhou 510180, China

Research funding:

National Natural Science Foundation of China (NSFC) (82170585);

National Natural Science Foundation of China (NSFC) (81970507);

The Project of Key Medical Discipline in Guangzhou (2021-2023);

Guangzhou Planned Project of Science and Technology (SL2022A03J01100);

National Natural Science Foundation of Guangdong Province (2021A1515011290)

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Corresponding author: ZHOU Yongjian, eyzhouyongjian@scut.edu.cn (ORCID: 0000-0003-1721-7639)
Received Date: 2023-05-04
Accepted Date: 2023-06-04
Published Date: 2023-08-20

Abstract

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease around the world. There is a close structural and functional relationship between the liver and the intestine, namely "the gut-liver axis", in which intestinal microbiota can participate in the development and progression of NAFLD through microbial translocation, production of endogenous ethanol, abnormal regulation of bile acid metabolism and choline metabolism, and endotoxemia. This article reviews the role of intestinal microbiota and metabolites in the development, progression, and treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease,
- Gastrointestinal Microbiome,
- Therapeutics

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References(50)

References

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Role of intestinal microbiota and metabolites in the development, progression, and treatment of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2023.08.006

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Role of intestinal microbiota and metabolites in the development, progression, and treatment of nonalcoholic fatty liver disease

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