HBV genotypes and efficacy of interferon-α on patients with chronic hepatitis B.

Yao Gang; Zhang Lian; Bao LiHua

Issue 5

May 2002

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Article Navigation > Journal of Clinical Hepatology > 2002 > 18(5): 273-274

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慢性乙型肝炎病毒基因型与干扰素治疗应答的关系

Published Date: 2002-05-20

Abstract

Abstract

To observe the relationship between HBV genotypes of chronic hepatitis B and efficacy of interferon-α therapy. A simplified RFLP method was established with AvaⅡ and DpnⅡ at amplified segment of the pre-S of HBV DNA. The method was applied to 60 serum samples from patients with chronic hepatitis B on IFN-α therapy. The genotype B was detected in 51 7% (31/60) . The difference was not significant in responsive rate to IFN-α therapy between genotype B and genotype C ( P >0 05) . Three patients of genotype D are effective on therapy. The Genotypes B and Genoltypes C are prevalent in a majority of area in our country. HBV genotypes might not be an important predictive factor in determining the efficacy of IFN-α therapy. The study indicates Genotype D is higher in responsive rate to IFN-α therapy.
- Hepatits B virus (HBV) ,
- Genotypes,
- Interferon-α (IFN-α) ,
- Restriction fragment length polymorphism (RFLP)

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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慢性乙型肝炎病毒基因型与干扰素治疗应答的关系

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慢性乙型肝炎病毒基因型与干扰素治疗应答的关系

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