Analysis of occult hepatitis B virus infection among blood donors in Tangshan, China

Cao Xiao; Cao QingBao; Zhang GuoQiang; Chang ZaiJuan; Li ShuPing; Xu WeiWei

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Feb. 2013

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Article Navigation > Journal of Clinical Hepatology > 2013 > 29(2): 117-119

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Analysis of occult hepatitis B virus infection among blood donors in Tangshan, China

Published Date: 2013-02-20

Abstract

Abstract

Objective To investigate the prevalence of occult hepatitis B virus (HBV) infection (OBI) among the volunteer blood donors in Tangshan, China.Methods Enzyme-linked immunosorbent assay was used to detect serum HBV markers in the blood donors.Nucleic acid test (NAT) was performed in the hepatitis B surface antigen (HBsAg) -negative blood samples to detect HBV DNA, and Roche reagent was used to measure the viral load of HBV DNA in NAT-positive samples.Results Among the HBsAg-negative blood samples of 116 741 blood donors, 39 (0.033%) had positive results in NAT, and 35 (0.029%) were confirmed with OBI.The viral load of HBV DNA was less than 102 IU/ml in 97.1% of the blood donors with OBI.Of the blood donors with OBI, 27 (77.1%) were positive for at least one of hepatitis B surface antibody (HBsAb) , hepatitis B e antigen, hepatitis B e antibody, and hepatitis B core antibody (HBcAb) , and 8 (22.9%) were negative for all serum HBV markers.Of the 27 positive blood donors, 22 (81.5%) were positive for HBcAb, and 15 (55.6%) were positive for HBsAb.Conclusion OBI occurs in some HBsAg-negative blood donors in Tangshan, and the viral load of HBV DNA is low.NAT is effective in increasing the detection rate of HBV infection.
- hepatitis B,
- hepatitis B virus,
- enzyme-linked immunosorbent assay

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References

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Analysis of occult hepatitis B virus infection among blood donors in Tangshan, China