Relationship between leptin resistance and nonalcoholic fatty liver in male patients.

Lu ZhenYa; Wang QunYan; Rao WeiQiang; Cai WeiMin

Issue 1

Jan. 2006

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Article Navigation > Journal of Clinical Hepatology > 2006 > 22(1): 39-41

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瘦素抵抗与男性非酒精性脂肪肝的关系

Published Date: 2006-01-20

Abstract

Abstract

To study the relationship between leptin resistance and nonalcoholic fatty liver (NAFL) in male patients.52 male patients with NAFL diagnosed by ultrasonographic examination and 45 healthy adults enrolled in study.Serum leptin was determined by radioimmunoassay.Fasting insulin (FINS) , fasting glucose (FPG) , TG, TC, HDL-C and LDL-C were also detected.The correlation between leptin and other parameter were analysised.Leptin levels in NAFL patients was found significantly higher than that in control group (6.75±1.32ng/ml vs 3.21±0.95ng/ml, P<0.01) .Leptin levels in obese patients was significantly higher than that in non-obese patients (7.95±0.85ng/ml VS 6.11±1.21ng/ml P<0.01) .HOMA-IR and Tg were also higher in the NAFL group than the control group.Logistic regression analysis revealed that in NAFL patients leptin concentration was negative correlation to HOMA-IR (r=-0.521, P<0.05) and positive correlation to BMI TG (r=0.781, P<0.01and r=0.425, P<0.05) , but there were no relation with Tc, HDL-C and LDH-C.Conclusion the serum leptin levels were significantly higher in patients with NAFL.It is evidence that patients with leptin resistance.Leptin resistance is avery important contributor to the pathogenesis of NAFL.
- fatty liver,
- leptin

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沈阳化工大学材料科学与工程学院沈阳 110142

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瘦素抵抗与男性非酒精性脂肪肝的关系

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瘦素抵抗与男性非酒精性脂肪肝的关系

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