Interstitial collagenase gene expression in patients with chronic liver disease

Wang AiMin; Wang BaoEn; Yang YueWei; Zhang Bin; Jiang LongAn; Du ShuangCun

Issue 2

Feb. 2000

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Article Navigation > Journal of Clinical Hepatology > 2000 > 16(2): 90-91+124

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慢性肝病间质胶原酶基因表达的研究

Published Date: 2000-02-20

Abstract

Abstract

WT5”BZ]In order to investigate the alteration of interstitial collagenase (MMP 1) gene expression in patients with chronic liver disease, 12 patients with chronic hepatitis, 13 patients with liver cirrhosis and 8 normal controls were selected and liver tissue was obtained by liver biopsy MMP 1 gene expression level was measured by quantitative analysis of reverse transcription polymerase chain reaction Results showed that MMP 1 gene expression levels in patients with chronic hepatitis and liver cirrhosis were higher than that of normal control The gene expression level in patients with chronic hepatitis was higher in comparison with that in patients with liver cirrhosis These results suggest that the alteration of MMP 1 gene expression in patients with chronic liver diseases might be an important factor which affecting the change of MMP 1 enzyme activity [WT5”HZ]
- WT5”BZ]chronic hepatitis liver cirrhosis interstitial collagenase gene expression reverse transcription polymerase chain reaction,

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[]〔1〕MaruyamaK , FeinmanL , FainsilberZ , etal Mammaliancollagenasein creaseinearlyalcoholicliverdiseaseanddecreasewithcirrhosis LifeSci ence, 198, 3 0∶13 79

[]〔2〕NoonanKE , BeckC , HolzmayerTA , etal QuantitativeanalysisofMDR1 (multidrugresistance) geneexpressioninhumantumorsbypolymerasechainreaction ProcNatlAcadSciUSA , 1990 , 87∶7160

[]〔3〕LichtinghagenR , HelmbrechtT , ArndtB , etal ExpressionPatternofma trixmetalloproteinasesinHumanLiver EurJClinChemClinBiochem , 1995 , 3 3∶65

〔4〕OkazakiI, MaruyamaK Collagenaseactivityinexperimentalhepaticfi brosis Nature, 1974, 2 5 2∶49

[]〔5〕王爱民 , 王宝恩 , 董忠 , 等。实验性肝纤维化过程中间质胶原酶活性的动态变化。中华消化杂志 , 1998, 18 ( 4 ) ∶2 13

[]〔6〕王爱民 , 王宝恩 , 董忠 , 等。慢性肝病患者血清间质胶原酶活性的研究。中华肝脏杂志 , 1996, 4∶2 2 3

[]〔7〕王爱民 , 王宝恩。细胞外基质的降解与肝纤维化。中华肝脏病杂志 , 1995 , 3∶12 1

[]〔8〕王爱民 , 王宝恩 , 杨跃伟 , 等。实验性肝纤维化金属蛋白酶组织抑制因子 -1基因表达的动态变化。中华实验外科杂志 , 1998, 15 ( 4 ) ∶3 5 2

[]〔9〕MurawakiY , KodaM , YamadaS , etal Serumcollagenaseactivityinpa tientswithchronicliverdisease J Hepatology , 1993 , 18∶3 2 8

[]〔10〕MurphyG , McAlpinCG , PollCT , etal PurificationandcharacterizationofabonemetalloproteinasethatdegradegelatinandtypeⅣandⅤcolla gen BiochimBiophysActa , 1985 , 83 1∶49

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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慢性肝病间质胶原酶基因表达的研究

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慢性肝病间质胶原酶基因表达的研究

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