Objective To study the significance of low liver iron load in the pathogenesis of Nonalcoholic steatohepatitis (NASH) in rats.Methods SD rats were randomly divided in to 4 groups:group 1 (control group) , group 2 (low liver iron load) , group 3 (model group) and group 4 (low liver iron load) .The levels of TG, TC, ALT, AST, SI, SOD and MDA in the serum and liver were measured after 12 weeks.Liver histopathologic change was observed.Results The serum levels of TG, TC, ALT, AST and MDA in group 3 were significantly higher than the control group.The serum SOD in group 3 was significantly lower than the control.There was no significant difference in SI between group 3 and the control group.The liver TG, TC, MDA and iron content in group 3 were significantly higher, and SOD was significantly lower than the control group.The serum TG, TC, ALT, AST, MDA and SI in group 4 were significantly lower and serum SOD was significantly higher than those in group 3.The TG, TC, MDA and iron content in the liver were significantly lower than those in group 3.The SOD in the liver of group 4 was significantly higher than those in group 3.The rate of lipid droplet in group 3 was higher.The liver inflammation scores and the iron load in group 4 were significantly lower than those in group 3.Conclusion Iron content highly increases in the liver of NASH rats.Low iron level can lessen the liver damage.
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