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Oct.  2011
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Article Navigation >  Journal of Clinical Hepatology  > 2011  >  27(10): 1106-1108

The advances of profibrogenic research of leptin and its signaling pathways in hepatic fibrosis

  • Published Date: 2011-10-20
    Abstract
  • Many kinds of chronic liver diseases can lead to hepatic fibrosis, which is the intermediate stage of liver cirrhosis.The activation of hepatic stellate cells plays a key role in the occurrence and development of liver fibrosis.Under the stimulation of inflammation, profibrogenic cytokines in the body activate their signaling pathways, so that the hepatic stellate cells change in morphology and function, causing collagen deposition.The leptin as a kind of profibrogenic cytokines, play an important role in the occurrence and development of hepatic fibrosis through its signal transduction mechanism.

     

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    • References(48)
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