2018 No. 11

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Editorial

Improve the knowledge of liver pathology and related skills among clinicians engaged in hepatology

Yang YongFeng

2018, 34(11): 2267-2270. DOI: 10.3969/j.issn.1001-5256.2018.11.001

Abstract(1438)

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Abstract:
Liver histopathological examination is an important method for the etiological diagnosis of liver injury. The pathological changes of liver diseases are characterized by“one cause with multiple consequences”and“multiple causes with one consequence”, and accurate diagnosis requires the combination of...

Discussions by experts

A comparative analysis of pathological grading and staging systems for chronic hepatitis

Tian AiPing, Yang YongFeng

2018, 34(11): 2271-2277. DOI: 10.3969/j.issn.1001-5256.2018.11.002

Abstract(2646)

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Abstract:
Liver biopsy plays an important role in the diagnosis and treatment of liver diseases and can give a comprehensive and detailed description of the morphology of lesions and objective grading and staging scores. There are several pathological grading and staging systems for chronic viral hepatitis an...

Pathological differential diagnosis of inflammatory liver injury

Jiang LiLin, Shen JianBo, Tang Hong, Lu ZhongHua

2018, 34(11): 2278-2282. DOI: 10.3969/j.issn.1001-5256.2018.11.003

Abstract(2735)

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Abstract:
Unexplained liver inflammatory injury has always been a difficult point in clinical differential diagnosis. This article briefly reviews the pathological changes of various liver diseases that cause inflammatory liver injury, including common/specific findings under a light microscope after HE stain...

Clinical and pathological features of cholestatic liver injury

Liu DuXian, Liu LanXia, Yang YongFeng

2018, 34(11): 2283-2288. DOI: 10.3969/j.issn.1001-5256.2018.11.004

Abstract(2057)

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Abstract:
Major causes of cholestasis include abnormal bile metabolism, obstructed bile flow and regurgitation, and bile duct injury and obstruction. Abnormal bile metabolism is mainly caused by gene abnormality, while obstructed bile flow is often caused by bile duct injury or occlusion due to cholangitis. A...

Pathological features of hepatic vascular diseases and key points in differential diagnosis

Luo WenPing, Ma Hong, Zhao XinYan

2018, 34(11): 2289-2294. DOI: 10.3969/j.issn.1001-5256.2018.11.005

Abstract(2234)

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Abstract:
Hepatic vascular diseases are a group of heterogeneous diseases which affect blood circulation in the liver. Although hepatic vascular diseases have a low incidence rate, they remain an important cause of portal hypertension. Patients often develop these diseases at a younger age, and misdiagnosis a...

Liver biopsy and related techniques in pathological diagnosis

Wu DongBo, Chen EnQiang, Bai Lang, Tang Hong

2018, 34(11): 2295-2299. DOI: 10.3969/j.issn.1001-5256.2018.11.006

Abstract(2545)

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Abstract:
Liver pathological examination plays an important role in guiding clinical treatment and evaluating disease prognosis, especially in the diagnosis of difficult liver diseases. The application of liver biopsy and proper pathological techniques helps pathologists to observe the morphological changes o...

Case reports

Han Xu, Li Jia, Zhou Li, Chen Chen, Wang ChunYan, Zhang Yan

2018, 34(11): 2397-2400. DOI: 10.3969/j.issn.1001-5256.2018.11.026

Abstract(1667)

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Abstract:

Fu Bin, He YongFeng, Guo LianBin, Chen XianShe, Yin PengFei, Liu Yi, Yang XiaoCui

2018, 34(11): 2401-2403. DOI: 10.3969/j.issn.1001-5256.2018.11.027

Abstract(1814)

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Abstract:

Liu HongYong, Gu Teng, Su JingHan, Tan LuDong, Fu Yu, Liu YaHui

2018, 34(11): 2404-2405. DOI: 10.3969/j.issn.1001-5256.2018.11.028

Abstract(1679)

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Abstract:

Gao Hui, Yin Xin, Zhang ChuanXia, Wen XiaoYu

2018, 34(11): 2406-2408. DOI: 10.3969/j.issn.1001-5256.2018.11.029

Abstract(1660)

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Abstract:

Zhi YiXiao, Qin ErYun, Pang MengYuan, Hua Rui

2018, 34(11): 2409-2410. DOI: 10.3969/j.issn.1001-5256.2018.11.030

Abstract(1692)

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Abstract:

Liu WenChao, Yang YongSheng, Jia MingKu, Fang He, Zhang Hang, Feng Mo, Yu ShiLi, Zhang XueWen

2018, 34(11): 2411-2412. DOI: 10.3969/j.issn.1001-5256.2018.11.031

Abstract(2080)

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Abstract:

Peng HanFei, Gong Jin, Li Qiang

2018, 34(11): 2413-2414. DOI: 10.3969/j.issn.1001-5256.2018.11.032

Abstract(1613)

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Abstract:

Reviews

Role of the Wnt signaling pathway in the development and progression of liver fibrosis

Zhao DongKang, Luo WeiWei, Yu ShuiPing

2018, 34(11): 2415-2419. DOI: 10.3969/j.issn.1001-5256.2018.11.033

Abstract(1574)

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Abstract:
Liver fibrosis has a complex pathogenesis and involves various intracellular and extracellular signal transduction pathways, but its specific pathogenesis remains unclear. Recent studies have confirmed that the activation of hepatic stellate cells due to abnormal activation of the Wnt signaling path...

Influence of abnormal spleen on liver pathophysiological function in patients with liver cirrhosis

Jiang XiaoNi, Liu Min, Li Qiang, Wang YuPing, Guo QingHong, Guan QuanLin, Zhou YongNing

2018, 34(11): 2420-2422. DOI: 10.3969/j.issn.1001-5256.2018.11.034

Abstract(1810)

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Abstract:
Splenomegaly is an early sign of cirrhotic portal hypertension. In patients with liver cirrhosis, the resistance of splenic venous reflux increases and portal venous pressure is reversed to the spleen, which causes congestive splenomegaly and hyperplasia of splenic tissue and fibrous tissue. In addi...

Research advances in the value of ultrasound elastography in the diagnosis of gastroesophageal varices in patients with liver cirrhosis

Dong Xue, Huang LiPing

2018, 34(11): 2424-2427. DOI: 10.3969/j.issn.1001-5256.2018.11.035

Abstract(1466)

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Abstract:
The presence of gastroesophageal varices ( GOV) is one of the independent risk factors for the death of patients with chronic liver diseases, and at present, non-selective β-blockers or endoscopic treatment is recommended for the prevention of variceal bleeding in patients with chronic liver disease...

Research advances in prognostic factors for patients with esophagogastric variceal bleeding

Lin FanYu, Huang Hua, Lu MingLiang

2018, 34(11): 2428-2432. DOI: 10.3969/j.issn.1001-5256.2018.11.036

Abstract(1613)

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Abstract:
Esophagogastric variceal bleeding is one of the most common complications of liver cirrhosis and is also one of the most critical diseases in the department of gastroenterology, with the features of acute onset and high rebleeding and mortality rates. Strengthening the understanding of related progn...

Research advances in gut microbiota in liver cirrhosis and related complications

Lu BingJie, Zhao YaHong, An YongTong, Ye Guan, Sun MingYu

2018, 34(11): 2433-2437. DOI: 10.3969/j.issn.1001-5256.2018.11.037

Abstract(1773)

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Abstract:
Liver cirrhosis is an end-stage fibrotic disease of chronic liver injury induced by various factors. Many studies have shown that gut microbiota ( GM) are involved in the development and progression of liver cirrhosis and related complications, such as portal hypertension, hepatic encephalopathy, sp...

Research advances in immune enhancement by heat shock protein 70 induced by local ablation for liver cancer

塔来提·吐尔干, 吐尔干艾力·阿吉

2018, 34(11): 2438-2442. DOI: 10.3969/j.issn.1001-5256.2018.11.038

Abstract(1516)

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Abstract:
Liver cancer still threatens human health nowadays, so it is urgent to explore new minimally invasive methods for the treatment of liver cancer. This article reviews the general status of liver cancer in China and describes local ablation and immunotherapy for liver cancer.This article also introduc...

Biological functions of apoptosis stimulating protein of p53 2 and its role in liver diseases

Zhang YiZhi, Shi HongBo, Chen Yu

2018, 34(11): 2443-2447. DOI: 10.3969/j.issn.1001-5256.2018.11.039

Abstract(1688)

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Abstract:
Apoptosis stimulating protein of p53 2 ( ASPP2) is a member of the apoptosis stimulating proteins of p53 and can specifically bind to the core region of p53 protein and enhance the ability of p53 to promote transcription of apoptotic genes. At present, it is believed that ASPP2 plays an important ro...

Research advances in the biomarkers for the early diagnosis of hepatorenal syndrome

Chen LanLan, Han Wen, Liu JingJing, Hu Dan, He WeiWei

2018, 34(11): 2448-2452. DOI: 10.3969/j.issn.1001-5256.2018.11.040

Abstract(1767)

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Abstract:
Hepatorenal syndrome ( HRS) is one of the most serious complications of end-stage liver disease. Type Ⅰ/Ⅱ HRS has a high short-term mortality rate and poor prognosis. The diagnostic criteria for HRS based on serum creatinine cannot keep up with the world, and early diagnosis is of great importance t...

Research advances in drugs for the prevention and treatment of gallstones

Xu JingChang, Ye Hui, Wang DaSong

2018, 34(11): 2453-2457. DOI: 10.3969/j.issn.1001-5256.2018.11.041

Abstract(2339)

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Abstract:
The treatment of gallstones mainly relies on surgery and endoscopy, and in recent years, a large number of studies have proposed new ideas and thoughts for drugs in the prevention and treatment of gallstones. This article summarizes the efficacy and safety of bile acid drugs, statins, ezetimibe, and...

Research advances in traditional Chinese medicine therapy for cholelithiasis

Zhou Qun, Wang YiXing, Liu Ping, Zhang Hua

2018, 34(11): 2458-2463. DOI: 10.3969/j.issn.1001-5256.2018.11.042

Abstract(3096)

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Abstract:
Cholelithiasis is a common disease in clinical practice. At present, surgery is the primary Western treatment method for this disease, but there are problems such as surgical trauma, a high recurrence rate, and postoperative complications. Various traditional Chinese medicine ( TCM) methods for the ...

Diagnosis, treatment, and prevention of postcholecystectomy syndrome

Liu HuanHuan, Tian Yu, Peng Yang, Yu JianFa, Xie FengXiao, Yang MingWei

2018, 34(11): 2464-2468. DOI: 10.3969/j.issn.1001-5256.2018.11.043

Abstract(3254)

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Abstract:
Postcholecystectomy syndrome ( PCS) is a common syndrome with complex etiologies after laparoscopic cholecystectomy, rather than a specific disease. In addition to bile duct stones, bile duct injury, and sphincter of Oddi dysfunction, PCS is also associated with the abnormalities in bile acid pool, ...

Research advances in immunotherapy for liver metastasis of pancreatic cancer

Jin TianQiang, Xu Feng, Dai ChaoLiu

2018, 34(11): 2469-2474. DOI: 10.3969/j.issn.1001-5256.2018.11.044

Abstract(2641)

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Abstract:
Patients with liver metastasis of pancreatic cancer have poor prognosis and few opportunities for surgery, and conventional radiochemotherapy lacks a satisfactory effect. As a new therapeutic strategy for tumor, immunotherapy fights against cancer by enhancing patients' immune function and may thus ...

Research advances in the role of autophagy and perineural invasion in pancreatic cancer

Yang YanHui, Zhang YuXiang, Gui Yang, Liu WeiFeng, Yang TianBao, Zhang YanTao, He ShaoJie, Sun JunJun, Fan Hua

2018, 34(11): 2475-2479. DOI: 10.3969/j.issn.1001-5256.2018.11.045

Abstract(2076)

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Abstract:
As a bi-directional tumor regulatory factor, autophagy plays an important role in the development, progression, and treatment of pancreatic cancer. Perineural invasion, a special pathway for tumor metastasis, has a high incidence rate in pancreatic cancer and is closely associated with high recurren...

Therapeutic guidelines

An excerpt of primary biliary cholangitis: 2018 practice guidance from the American Association for the Study of Liver Diseases

Wang Lu, Han Ying

2018, 34(11): 2300-2304. DOI: 10.3969/j.issn.1001-5256.2018.11.007

Abstract(2255)

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Abstract:

An excerpt of EASL Clinical Practice Guidelines on nutrition in chronic liver disease (2018)

Zhou YiXia, Gao Ya, Li Wu

2018, 34(11): 2305-2310. DOI: 10.3969/j.issn.1001-5256.2018.11.008

Abstract(327)

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Abstract:

An excerpt of endoscopic biliary stenting: Indications, choice of stents, and results: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline-updated 2018

Li JiaSu, Liu Feng, Li ZhaoShen

2018, 34(11): 2311-2315. DOI: 10.3969/j.issn.1001-5256.2018.11.009

Abstract(472)

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Abstract:

NCCN guidelines update (Version2.2018): Pancreatic adenocarcinoma

Meng ZhangTing, Li XiaoQing

2018, 34(11): 2316-2323. DOI: 10.3969/j.issn.1001-5256.2018.11.010

Abstract(1708)

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Abstract:

An excerpt of nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS)

Xiong JiaGeng, Yang GuiYuan, Qian ZhuYin

2018, 34(11): 2324-2328. DOI: 10.3969/j.issn.1001-5256.2018.11.011

Abstract(273)

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Abstract:

Original articles_Liver fibrosis and liver cirrhosis

Diagnostic efficacy of shear wave elastography in evaluating chronic hepatitis B liver fibrosis and related influencing factors

Liu BoRu, Dong Xue, Huang LiPing

2018, 34(11): 2329-2333. DOI: 10.3969/j.issn.1001-5256.2018.11.012

Abstract(2233)

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Abstract:

Objective To investigate the diagnostic efficiency of shear wave elastography ( SWE) in evaluating chronic hepatitis B ( CHB) liver fibrosis and related influencing factors. Methods A total of 147 CHB patients who visited Shengjing Hospital of China Medical University from January 2016 to September ...

Predictive value of Gteborg University Cirrhosis Index score in noninvasive diagnosis of liver fibrosis in patients with chronic hepatitis B virus infection

Tao Ben, Cao WenJun, Bao Teng, Gao YuFeng, Ye Jun, Zou GuiZhou

2018, 34(11): 2334-2340. DOI: 10.3969/j.issn.1001-5256.2018.11.013

Abstract(2086)

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Abstract:

Objective To investigate the predictive value of G9 teborg University Cirrhosis Index ( GUCI) score in the noninvasive diagnosis of liver fibrosis stage in patients with chronic hepatitis B virus ( HBV) infection by comparing it with the classical noninvasive serological diagnosis models of aspartat...

Value of liver stiffness-spleen diameter-to-platelet ratio score in predicting esophageal varices in patients with liver cirrhosis

Zhou JiaMei, Ban ZhiChao, Li Yan, Zhang XiaoJuan, Zhang YongHua, Wang MingLei

2018, 34(11): 2341-2344. DOI: 10.3969/j.issn.1001-5256.2018.11.014

Abstract(2119)

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Abstract:

Objective To investigate the value of liver stiffness-spleen diameter-to-platelet ratio score ( LSPS) in predicting esophageal varices ( EV) in patients with liver cirrhosis. Methods A total of 76 patients with liver cirrhosis who visited The Second Central Hospital of Baoding from October 2012 to A...

Original articles_Liver neoplasms

Clinical effect of Shenqi Gankang tablets combined with antiviral therapy after transcatheter arterial chemoembolization in treatment of hepatitis B virus-related hepatocellular carcinoma

Yang DaoKun, Wei Shuai, Gao HaiLi, Wang XinWei, Liang HaiJun

2018, 34(11): 2345-2351. DOI: 10.3969/j.issn.1001-5256.2018.11.015

Abstract(2141)

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Abstract:

Objective To investigate the clinical effect of Shenqi Gankang tablets combined with antiviral therapy after transcatheter arterial chemoembolization ( TACE) in the treatment of hepatitis B virus ( HBV) -related hepatocellular carcinoma ( HCC) . Methods A total of106 patients with HBV-related HCC wh...

A threshold analysis of alpha-fetoprotein in diagnosis and screening of hepatocellular carcinoma

Tian Zhou, Zhang JianHuai

2018, 34(11): 2352-2355. DOI: 10.3969/j.issn.1001-5256.2018.11.016

Abstract(2252)

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Abstract:

Objective To investigate the optimal cut-off value of alpha-fetoprotein ( AFP) in the diagnosis and early screening of hepatocellular carcinoma ( HCC) . Methods The clinical data of 2212 HCC patients who were diagnosed and hospitalized in our hospital and 1998 non-HCC patients were collected, and th...

Pathological features of hepatic epithelioid hemangioendothelioma: An analysis of 5 cases

Chen YiHua, Wang Chao, Jiang Rui, Tang ShanHong, Luo Yan, Ceng DongMei, He XiaoYan, Shi GuangJing

2018, 34(11): 2356-2359. DOI: 10.3969/j.issn.1001-5256.2018.11.017

Abstract(2017)

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Abstract:

Objective To investigate the clinicopathological features of hepatic epithelioid hemangioendothelioma ( HEHE) . Methods The clinical data, histopathological data, and immunohistochemical results of 5 patients with HEHE were observed. Results There were 3 male and 2 female patients. Major clinical ma...

Original articles_Pancreatic diseases

Association between triglyceride level and the severity of acute hypertriglyceridemic pancreatitis

Gao Feng, Yan Zhen, Zhang Jie

2018, 34(11): 2360-2363. DOI: 10.3969/j.issn.1001-5256.2018.11.018

Abstract(1863)

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Abstract:

Objective To investigate the association between serum triglyceride ( TG) level and the severity of acute hypertriglyceridemic pancreatitis ( AHTGP) . Methods A retrospective analysis was performed for the clinical data of 63 patients with AHTGP who were hospitalized and treated in Beijing Anzhen Ho...

Original articles_Others

Clinical features of cholestatic liver disease of 107 cases

Xu Xin, Dai YiChen, Xuan ShiYing

2018, 34(11): 2364-2367. DOI: 10.3969/j.issn.1001-5256.2018.11.019

Abstract(1733)

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Abstract:

Objective To investigate the clinical features of cholestatic liver disease ( CLD) , and to provide a reference for strengthening the diagnosis and treatment of this disease. Methods A retrospective analysis was performed for the clinical data of 107 patients who were admitted to Chenggong Hospital ...

Clinical effect of fenofibrate combined with ursodeoxycholic acid in treatment of primary biliary cholangitis patients with poor response to ursodeoxycholic acid alone

Wang Lu, Sun KeShuai, Han ZheYi, Guo ZhangCun, Jia Gui, Gao KeNa, Zhang YaWei, Han Ying

2018, 34(11): 2368-2372. DOI: 10.3969/j.issn.1001-5256.2018.11.020

Abstract(2353)

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Abstract:

Objective To investigate the clinical effect of fenofibrate combined with ursodeoxycholic acid ( UDCA) in the treatment of primary biliary cholangitis ( PBC) patients with poor response to UDCA alone. Methods A total of 67 PBC patients with poor response to UDCA who were treated in Xijing Hospital o...

Mechanism of action of Daifan powder in the prevention and treatment of primary biliary cholangitis via its interventional effect on Th17/Treg balance

Zhan Kai, Xu Yan, Han MengLing, Cheng LiangBin

2018, 34(11): 2373-2378. DOI: 10.3969/j.issn.1001-5256.2018.11.021

Abstract(1985)

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Abstract:

Objective To investigate the effect of different doses of Daifan powder on peripheral blood T helper 17 ( Th17) cells, CD4+CD25+Foxp3+regulatory T ( Treg) cells, and Th17/Treg ratio in a mouse model of primary biliary cholangitis ( PBC) induced by polyinosinic-polycytidylic acid ( Poly I∶ C) and the...

Association between rs2943650 mutation and insulin resistance in patients with chronic liver disease and type 2 diabetes mellitus

Dou AiHua, Hui Wei, Liu Mei, Wei LinLin, Zhao Juan, Ma ChunHua, Zheng XiaoQin, Xiong Fang, Yang Xue, Zhang Mei, Xu Bin

2018, 34(11): 2379-2382. DOI: 10.3969/j.issn.1001-5256.2018.11.022

Abstract(2017)

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Abstract:

Objective To investigate the features of insulin resistance in patients with liver disease and diabetes and possible pathways leading to insulin resistance. Methods A total of 67 patients with liver disease and type 2 diabetes who were admitted to Beijing You'an Hospital from September 2017 to March...

Effect of plasma exchange on bioactivity of peripheral blood CD34+ cells in patients with acute-on-chronic (subacute) liver failure

Wu YiChen, Yao HongYu, Wang KaiLi, Jiang QiYu, Liu Chang, Xing HanQian, Liu SuXia, You ShaoLi, Zhao Jun

2018, 34(11): 2383-2387. DOI: 10.3969/j.issn.1001-5256.2018.11.023

Abstract(506)

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Abstract:

Objective To investigate the effect of improvement in internal environment after plasma exchange on the bioactivity of peripheral blood CD34+cells in patients with acute-on-chronic ( subacute) liver failure. Methods The peripheral blood CD34+cells from patients with acute-on-chronic ( subacute) live...

A new prognostic model for pregnancy-specific liver disease

Lu: SuCong

2018, 34(11): 2388-2391. DOI: 10.3969/j.issn.1001-5256.2018.11.024

Abstract(1937)

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Abstract:

Objective To investigate the prognostic factors for pregnancy-specific liver disease ( PSLD) , to establish a simple effective model ( NEW mode) using the statistic method, and to investigate the value of Model for End-Stage Liver Disease ( MELD) and NEW model in the prognostic evaluation of PSLD pa...

Experience in diagnosis and treatment of acute graft-versus-host disease after liver transplantation of 8 cases

Zhao XiaoFei, Lin DongDong, Li Ning, Zang YunJin, Guo QingLiang, Wu JuShan, Sun LiBo

2018, 34(11): 2392-2396. DOI: 10.3969/j.issn.1001-5256.2018.11.025

Abstract(1940)

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Abstract:

Objective To investigate the diagnosis and treatment of acute graft-versus-host disease ( aGVHD) after liver transplantation.Methods This report included 8 patients treated with liver transplantation who were admitted to the Liver Transplantation Center of Beijing YouAn Hospital from April 2011 to A...