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Article Navigation >  Journal of Clinical Hepatology  > 2018  >  34(11): 2420-2422

Influence of abnormal spleen on liver pathophysiological function in patients with liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2018.11.034
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  • Published Date: 2018-11-20
    Abstract
  • Splenomegaly is an early sign of cirrhotic portal hypertension. In patients with liver cirrhosis, the resistance of splenic venous reflux increases and portal venous pressure is reversed to the spleen, which causes congestive splenomegaly and hyperplasia of splenic tissue and fibrous tissue. In addition, intestinal antigens enter the systemic circulation via the portal-systemic collateral circulation and stimulates the proliferation of mononuclear macrophages in the spleen after being taken up by the spleen, which further leads to splenomegaly and hypersplenism. On the contrary, abnormal spleen can cause the changes in liver function and portal vein hemodynamics. Therefore, the intervention of the spleen cannot be neglected during the treatment of liver cirrhosis and its complications. This article reviews the influence of abnormal spleen structure and function on liver pathophysiological function in patients with liver cirrhosis.

     

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