2018 No. 10

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Editorial

Pathogenesis and multidisciplinary diagnosis and treatment of portal vein embolization

Zhu FengShang, Yang ZhangQing

2018, 34(10): 2043-2046. DOI: 10.3969/j.issn.1001-5256.2018.10.001

Abstract(1976)

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Abstract:
Portal vein embolization involves different pathophysiological processes such as primary or secondary portal vein thrombosis and extrahepatic portal vein occlusion. After clarifying the connotation of portal vein embolization, this article briefly introduces the etiology and grading system of portal...

Discussions by experts

Treatment of portal vein thrombosis: Selection of anticoagulants

Zhang Yu, Liu FuQuan

2018, 34(10): 2047-2052. DOI: 10.3969/j.issn.1001-5256.2018.10.002

Abstract(2321)

PDF (1601KB)(549)

Abstract:
Portal vein thrombosis ( PVT) has become a common disease in clinical practice, and with the development of digital imaging, the detection rate of PVT has been increased significantly. PVT treatment is a multimodality therapy based on anticoagulant therapy and includes interventional treatment and s...

Interventional treatment of portal vein thrombosis

Ma JingQin, Luo JianJun

2018, 34(10): 2053-2057. DOI: 10.3969/j.issn.1001-5256.2018.10.003

Abstract(3514)

PDF (1816KB)(417)

Abstract:
With the increase in the diagnosis rate of portal vein thrombosis ( PVT) , the interventional treatment for PVT has attracted more and more attention. Mechanical thrombolysis and drug thrombolysis combined with systemic anticoagulant treatment can partly or even completely reverse the local and syst...

Surgical diagnosis and treatment of portal vein thrombosis

Zhang Ying, Liu QingYan, Li ZhiWei

2018, 34(10): 2058-2062. DOI: 10.3969/j.issn.1001-5256.2018.10.004

Abstract(2302)

PDF (1811KB)(459)

Abstract:
Portal vein thrombosis refers to thrombotic lesions in the portal vein and is caused by various etiologies. Its clinical manifestations vary with location, extension, degree of vascular occlusion, and formation time, and severe thrombosis may cause gastrointestinal congestion and necrosis, liver ins...

Mechanisms of the development and progression of portal vein thrombosis

Yang YuanYuan, Wang XiaoYan

2018, 34(10): 2063-2068. DOI: 10.3969/j.issn.1001-5256.2018.10.005

Abstract(2156)

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Abstract:
Portal vein thrombosis ( PVT) refers to the process of thrombosis in the portal vein or its branches and can lead to portal hypertension and a series of pathophysiological changes. PVT is often caused by various etiologies, including hypercoagulable state, reduced portal flow velocity, and vascular ...

Source of portal vein tumor thrombosis and advances in its diagnosis and treatment

Hu MuRen, Ge BuJun

2018, 34(10): 2069-2075. DOI: 10.3969/j.issn.1001-5256.2018.10.006

Abstract(2441)

PDF (1615KB)(415)

Abstract:
Portal vein tumor thrombosis is one of the important factors that affect the treatment and prognosis of patients with malignancies.The early diagnosis and treatment of portal vein tumor thrombosis is of great significance to improve the prognosis of patients. However, at present, there is no standar...

Therapeutic guidelines

Guidelines on the management of hepatic encephalopathy in cirrhosis

Chinese Society of Hepatology, Chinese Medical Association

2018, 34(10): 2076-2089. DOI: 10.3969/j.issn.1001-5256.2018.10.007

Abstract(3936)

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Abstract:

Strategies of primary prevention of liver cancer in China: Expert Consensus ( 2018)

Prevention of Infection Related Cancer (PIRCA) Group, Specialized Committee of Cancer Prevention and Control, Chinese Preventive Medicine Association, Non-communicable & Chronic Disease Control and Prevention Society, Chinese Preventive Medicine Association, Health Communication Society, Chinese Preventive Medicine Association

2018, 34(10): 2090-2097. DOI: 10.3969/j.issn.1001-5256.2018.10.008

Abstract(715)

PDF (315KB)(1340)

Abstract:

Liver cancer is one of the most common cancers in China. The major risk factors are chronic infections of hepatitis B virus ( HBV) , hepatitis C virus ( HCV) , high exposure to aflatoxins. In addition, exposure to cyanotoxins and some preventable health behaviors are also recognized to contribute to...

Expert consensus on the imaging-guided multimode tumor ablation therapy system for malignant hepatic tumors

The Society of Interventional Therapy， China Anti- cancer Association, The Solid Tumor Theranostics Committee， Shanghai Anti- cancer Association

2018, 34(10): 2098-2102. DOI: 10.3969/j.issn.1001-5256.2018.10.009

Abstract(2583)

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Abstract:

Imaging-guided multimode tumor ablation therapy system for malignant hepatic tumors is a therapeutic technique, the performance of which is guided by medical imaging technology, and in the process of alternate conversion between cryoablation and thermal ablation, through accurate control of lesion a...

Consensus for diagnosis and treatment of nonalcoholic fatty liver diseases and metabolic disorders (2nd Edition)

Chinese Society of EndocrinologyChinese Medical Association

2018, 34(10): 2103-2108. DOI: 10.3969/j.issn.1001-5256.2018.10.010

Abstract(610)

PDF (260KB)(759)

Abstract:

Comprehensive guidelines for the diagnosis and treatment of pancreatic cancer (2018 version)

Pancreatic Cancer Committee of Chinese Anti-Cancer Association

2018, 34(10): 2109-2120. DOI: 10.3969/j.issn.1001-5256.2018.10.011

Abstract(6704)

PDF (433KB)(3885)

Abstract:

Pancreatic cancer ranks the fifth leading cause of cancer-related death, while the incidence has increased in the recent years.Although available diagnosis and treatment have failed to significantly improve patients' outcome, some advances have been made along with the understanding of the new conce...

An excerpt of WHO guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection (2018)

Zhang LiJuan, Liu BingHua, Ma CuiHua, Du HuiQing, Han Tao, Jiang Yong

2018, 34(10): 2121-2123. DOI: 10.3969/j.issn.1001-5256.2018.10.012

Abstract(2585)

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Abstract:

Original articles_Liver fibrosis and liver cirrhosis

An analysis of urinary factors for predicting acute kidney injury in patients with liver cirrhosis

Xu ManMan, Chen Yu

2018, 34(10): 2124-2129. DOI: 10.3969/j.issn.1001-5256.2018.10.013

Abstract(2187)

PDF (1682KB)(387)

Abstract:
Objective To investigate the predictive factors for acute kidney injury ( AKI) in patients with liver cirrhosis. Methods A total of 105 patients with decompensated liver cirrhosis who visited Beijing YouAn Hospital from May 2017 to April 2018 were enrolled. These patients were divided into AKI group...

Predictive value of coagulation test parameters for acute upper gastrointestinal bleeding in patients with liver cirrhosis

Zhang LiHang, Wang ShanJuan, Lu LunGen, Liu YanLi, Wang YiFei, Xie JinBi

2018, 34(10): 2130-2135. DOI: 10.3969/j.issn.1001-5256.2018.10.014

Abstract(2251)

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Abstract:
Objective To investigate the association between coagulation test parameters and acute upper gastrointestinal bleeding ( AUGIB) in patients with liver cirrhosis. Methods A total of 233 patients with liver cirrhosis who were hospitalized in Department of Gastroenterology, Jiading District Central Hos...

Effect of spleen-strengthening, dampness-removing, and hemostatic prescription on rebleeding within one year in cirrhotic patients with esophagogastric variceal bleeding

Hou YiXin, Zhang Qun, Yang ZhiYun, Yang YuYing, Jiang YuYong, Wang XianBo

2018, 34(10): 2136-2141. DOI: 10.3969/j.issn.1001-5256.2018.10.015

Abstract(2849)

PDF (1632KB)(337)

Abstract:
Objective To investigate the effect of spleen-strengthening, dampness-removing, and hemostatic prescription on rebleeding within one year in cirrhotic patients with esophagogastric variceal bleeding ( EGVB) . Methods A total of 750 cirrhotic patients with EGVB who were admitted to Beijing Ditan Hosp...

Original articles_Liver neoplasms

Influence of portal vein tumor thrombus on the clincial effect of FOLFOX4 chemotherapy regimen in treatment of advanced hepatocellular carcinoma

Yang Guang, Dong YaBing, Zhao LingLing, Cui GuoZhen, Zhao HengJun, Wang NanYa

2018, 34(10): 2142-2147. DOI: 10.3969/j.issn.1001-5256.2018.10.016

Abstract(2307)

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Abstract:
Objective To investigate the clinical effect of oxaliplatin-based chemotherapy regimen in the treatment of advanced hepatocellular carcinoma ( HCC) with portal vein tumor thrombus. Methods A retrospective analysis was performed for the clinical data of 37 patients who were diagnosed with BCLC stage ...

Value of serum des-γ-carboxy-prothrombin in the diagnosis and treatment of hepatocellular carcinoma

Sun Yu, Zhang HongHai, Yuan ChunWang, Hu CaiXia, Liu BoJun, Cui ShiChang, Qian ZhiLing, Zhang YingHua, Zhang YongHong, Zheng JiaSheng

2018, 34(10): 2148-2152. DOI: 10.3969/j.issn.1001-5256.2018.10.017

Abstract(2781)

PDF (1595KB)(411)

Abstract:
Objective To investigate the expression of des-γ-carboxy-prothrombin ( DCP) in serum in hepatocellular carcinoma ( HCC) patients and its association with tumor properties, pathology, and clinical features. Methods A total of 80 patients who were hospitalized and treated in our hospital from January ...

Expression of D-bifunctional protein in hepatocellular carcinoma tissue and its correlation with alpha-fetoprotein and carbohydrate antigen 19-9

Lu Xin, Kong LingYu, Liu DianQing, Xu LinJi, Qiu Ning, Cheng Hua

2018, 34(10): 2153-2156. DOI: 10.3969/j.issn.1001-5256.2018.10.018

Abstract(1984)

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Abstract:
Objective To investigate the expression of D-bifunctional protein ( DBP) in hepatocellular carcinoma ( HCC) tissue and its correlation with serum tumor markers alpha-fetoprotein ( AFP) and carbohydrate antigen 19-9 ( CA19-9) , as well as the clinical value of DBP in early diagnosis and prognostic ev...

Original articles_Biliary diseases

Influencing factors for the prognosis of patients with early-stage intrahepatic cholangiocarcinoma after radical resection

Huang Jian, Jiang BeiGe, Yang Yuan, Gu FangMing, Yuan ShengXian, Pan ZeYa

2018, 34(10): 2157-2163. DOI: 10.3969/j.issn.1001-5256.2018.10.019

Abstract(2038)

PDF (1791KB)(363)

Abstract:
Objective To investigate the influencing factors for the prognosis of patients with early-stage intrahepatic cholangiocarcinoma ( ICC) after surgical treatment. Methods A total of 155 patients with early-stage ICC who underwent radical resection in The Third Affiliated Hospital of Second Military Me...

Original articles_Others

Clinical features of autoimmune hepatitis in children: An analysis of 10 cases

Chen Jie, Liu YanMin, Huang ChunYang, Huang YunLi, Zhang XiaoDan, Ren MeiXin, Du XiaoFei, Bian XinQu, Liao HuiYu, Han Ying, Dan Jing

2018, 34(10): 2164-2168. DOI: 10.3969/j.issn.1001-5256.2018.10.020

Abstract(2386)

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Abstract:

Objective To investigate the clinical features and treatment outcome of children with autoimmune hepatitis ( AIH) . Methods A retrospective analysis was performed for the clinical data, liver pathology, treatment outcome, and follow-up data of 10 children with AIH who were treated in Beijing YouAn H...

Association between MBOAT7 rs641738 polymorphism and nonalcoholic fatty liver disease

Liao SongLing, Liu ShouSheng, Wang Cong, Chen LiZhen, Xin YongNing, Xuan ShiYing

2018, 34(10): 2169-2174. DOI: 10.3969/j.issn.1001-5256.2018.10.021

Abstract(2673)

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Abstract:

Objective To investigate the association between MOBAT7 rs641738 polymorphism and the development of NAFLD in the Chinese Han population in Qingdao, China, and to provide a theoretical basis for the prevention and treatment of NAFLD and its complication.Methods A total of 113 NAFLD patients who were...

Effect of salvianolic acid B on oxidative stress in a cell model of nonalcoholic fatty liver disease

Chen XiaoQing, Ren YuFei, Kong WeiZong, Wang YingChun

2018, 34(10): 2175-2181. DOI: 10.3969/j.issn.1001-5256.2018.10.022

Abstract(2311)

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Abstract:

Objective To establish a cell model of nonalcoholic fatty liver disease ( NAFLD) by inducing HepG2 cells with oleic acid ( OA) in vitro, and to investigate the effect of salvianolic acid B ( Sal B) on oxidative stress in NAFLD cells and its possible mechanisms via the intervention of NAFLD cells wit...

Risk factors for variceal rebleeding after esophagogastric devascularization and splenectomy in patients with portal hypertension

Zhao XiaoFei, Lin DongDong, Li Ning, Zang YunJin, Guo QingLiang, Wu JuShan

2018, 34(10): 2182-2185. DOI: 10.3969/j.issn.1001-5256.2018.10.023

Abstract(2303)

PDF (1579KB)(364)

Abstract:

Objective To investigate the risk factors for variceal rebleeding after esophagogastric devascularization and splenectomy in patients with portal hypertension. Methods A retrospective analysis was performed for the clinical data of 244 patients with portal hypertension who were admitted to Beijing Y...

Clinical features of hemophagocytic lymphohistiocytosis with abnormal liver function as the initial manifestation

Ceng QingHuan, Sun YaNan, Liu YuanZhi, Li Peng, Yu HaiBin, Wu YanJing, Xiong Feng, Zhang ShiBin

2018, 34(10): 2186-2189. DOI: 10.3969/j.issn.1001-5256.2018.10.024

Abstract(2267)

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Abstract:

Objective To investigate the clinical and laboratory features of hemophagocytic lymphohistiocytosis ( HLH) with abnormal liver function as the initial manifestation, and to increase the awareness of this disease. Methods A retrospective analysis was performed for the clinical data of 11 patients who...

Case reports

Acute hepatitis E with hyperthyroidism: A case report

Kui YiWen, Mao MiaoMiao, Dong KaiHui, Jin QingLong

2018, 34(10): 2190-2191. DOI: 10.3969/j.issn.1001-5256.2018.10.025

Abstract(1641)

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Abstract:

A case of congenital hepatic fibrosis with lgG4-related disease

Li ZhengXin, Xing Feng, Zhou Yang, Chen GaoFeng, Liu ChengHai

2018, 34(10): 2192-2194. DOI: 10.3969/j.issn.1001-5256.2018.10.026

Abstract(2103)

PDF (1634KB)(340)

Abstract:

Hepatolenticular degeneration with polycystic ovary syndrome: a case report

Huang DeLiang, Zhu ZhiBin, Yu Hong, Zhao Qi, Jiang JinYan, Chen YuanYuan, Dai Wei

2018, 34(10): 2195-2196. DOI: 10.3969/j.issn.1001-5256.2018.10.027

Abstract(2142)

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Abstract:

A case of paroxysmal nocturnal hemoglobinuria with Budd-Chiari syndrome as the first manifestation

Wu KaiMin, Cao Shan, Zhang GuoYan, Chen GuoDong, Su Lin, Wang ZhiFeng, Liu YuLan

2018, 34(10): 2197-2199. DOI: 10.3969/j.issn.1001-5256.2018.10.028

Abstract(2105)

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Abstract:

Acute drug-induced liver injury progressing to chronic drug-induced liver injury with autoimmune hepatitis-like syndrome: A case report

Li Chen, Su HaiBin, Liu XiaoYan, Xu Xiang, Li Hui, Hu JinHua

2018, 34(10): 2200-2202. DOI: 10.3969/j.issn.1001-5256.2018.10.029

Abstract(2118)

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Abstract:

A case of portopulmonary hypertension

Yin Xin, Gao Hui, Zhang Yu, Zhang MingYuan, Jin QingLong, Wen XiaoYu

2018, 34(10): 2203-2205. DOI: 10.3969/j.issn.1001-5256.2018.10.030

Abstract(2009)

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Abstract:

A case of missed diagnosis of IgG4-related sclerosing cholangitis

Du HengRui, Wang ZhenJiang, Ren YanXian, Ma ZhiJian, Wang KeShen, Zhan Hao, Yu ZeYuan, Jiao ZuoYi

2018, 34(10): 2206-2207. DOI: 10.3969/j.issn.1001-5256.2018.10.031

Abstract(2039)

PDF (1596KB)(340)

Abstract:

Reviews

Research advances in the application of antiviral drugs during pregnancy for blocking mother-to-child transmission of hepatitis B virus

Wang HuiJuan, Duan ZhongPing, Zhang HuanHu, Ren Feng

2018, 34(10): 2208-2212. DOI: 10.3969/j.issn.1001-5256.2018.10.032

Abstract(2122)

PDF (1606KB)(509)

Abstract:
Mother-to-child vertical transmission is an important route of transmission for hepatitis B virus ( HBV) infection in patients with chronic hepatitis B, and the rate of HBV infection increases with the increase in the mother's HBV viral load. Although active and passive immunoprophylaxis has been im...

Management and prevention of HBV reactivation in the context of immunosuppression

Dong KaiHui, Fang YiNa, Kui YiWen, Mao MiaoMiao, Guan YanEr, Wen XiaoYu, Jin QingLong

2018, 34(10): 2213-2216. DOI: 10.3969/j.issn.1001-5256.2018.10.033

Abstract(2182)

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Abstract:
HBV reactivation is commonly seen during immunosuppressive therapy and is associated with high incidence and mortality rates due to hepatitis outbreak and liver decompensation, and therefore, it should be taken seriously. However, the prevention and management of this potential complication is still...

Dual role of autophagy in hepatitis B virus and related liver diseases

Peng JiaLi, Lai Xin, Wei Jia

2018, 34(10): 2217-2220. DOI: 10.3969/j.issn.1001-5256.2018.10.034

Abstract(2476)

PDF (1581KB)(432)

Abstract:
Autophagy is a process of lysosome degradation and has a dual role in the development and progression of diseases, i. e., it can promote cell survival and induce cell death. This article introduces the dual role of autophagy in hepatitis B virus ( HBV) , chronic hepatitis B, liver fibrosis, and hepa...

Significance of hepatitis B virus pregenomic RNA in the progression of chronic hepatitis B

Tan Ning, Luo Hao, Xu XiaoYuan

2018, 34(10): 2221-2223. DOI: 10.3969/j.issn.1001-5256.2018.10.035

Abstract(3527)

PDF (1573KB)(491)

Abstract:
Hepatitis B virus ( HBV) pregenomic RNA ( pgRNA) is the direct transcription product of HBV covalently closed circular DNA ( cccDNA) and can reflect the transcriptional activity of HBV cccDNA and the progression of chronic hepatitis B, which provides guidance for clinical treatment and prognostic pr...

Research advances in anticoagulant therapy for liver fibrosis

Xia YiFu, Zhang ChunQing

2018, 34(10): 2224-2226. DOI: 10.3969/j.issn.1001-5256.2018.10.036

Abstract(2137)

PDF (1564KB)(429)

Abstract:
Liver fibrosis is a pathological process in which chronic liver disease develops into liver cirrhosis. It is caused by diffuse proliferation of liver fibrous tissue on the basis of extensive necrosis of liver cells, resulting in destruction of the normal structure and blood supply of liver lobules. ...

Research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis

Chen YanZhen, Chen ChengLiang, Hong Yu, Wang Guan, Jiao Jian

2018, 34(10): 2227-2231. DOI: 10.3969/j.issn.1001-5256.2018.10.037

Abstract(2318)

PDF (1609KB)(491)

Abstract:
At present, non-alcoholic fatty liver disease ( NAFLD) has become the major cause of chronic liver disease in the world and is considered a common pathogenic factor of cryptogenic cirrhosis. In clinical practice, NAFLD is commonly seen in obese patients; however, it is not rare among non-obese indiv...

Research advances in the treatment of nonalcoholic fatty liver disease

Suo YuHong, Liu JinChun

2018, 34(10): 2232-2236. DOI: 10.3969/j.issn.1001-5256.2018.10.038

Abstract(1827)

PDF (1594KB)(417)

Abstract:
Nonalcoholic fatty liver disease ( NAFLD) has become the leading cause of abnormal liver enzymes in healthy individuals in China. Due to the complex pathogenesis of NAFLD, no consensus has been reached on the treatment of this disease. However, in recent years, more and more studies have put forward...

Thromboprophylaxis and bleeding control in patients with liver disease in the intensive care unit

Xing WenLi, Li Qian

2018, 34(10): 2237-2240. DOI: 10.3969/j.issn.1001-5256.2018.10.039

Abstract(1903)

PDF (1586KB)(380)

Abstract:
Liver diseases are associated with complex abnormalities in the coagulation system as the liver is involved in the synthesis of various coagulation-related proteins. Laboratory and clinical evidence suggests that patients with liver disease may achieve a state of rebalanced hemostasis, but such bala...

Application of anticoagulants after transjugular intrahepatic portosystemic shunt

Jiang MingYuan, Huang Hua, Lu MingLiang, Lin FanYu, Zhang YingYuan

2018, 34(10): 2241-2244. DOI: 10.3969/j.issn.1001-5256.2018.10.040

Abstract(2175)

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Abstract:
Transjugular intrahepatic portosystemic shunt ( TIPS) , after nearly 30 years of continuous exploration and development, has been widely used in the treatment of complications of portal hypertension. TIPS has significant advantages in acute esophagogastric variceal bleeding, prevention of rebleeding...

Research advances in endoscopic treatment of biliary complications after liver transplantation

Xu Hui, Li Bing

2018, 34(10): 2245-2250. DOI: 10.3969/j.issn.1001-5256.2018.10.041

Abstract(366)

PDF (328KB)(98)

Abstract:
Liver transplantation remains the ultimate treatment regimen for patients with end-stage liver disease or acute liver failure. The incidence rate of biliary complications has significantly decreased with the improvement and development of organ preservation, novel immunosuppressants, perioperative m...

Individualized treatment of calculous cholecystitis

Du QianCheng, Zhou Ying, Zhang LingQiang, Hu ChenLiang, Fan HaiNing

2018, 34(10): 2251-2256. DOI: 10.3969/j.issn.1001-5256.2018.10.042

Abstract(2039)

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Abstract:
Calculous cholecystitis is a common disease in clinical practice. There are various therapies for this disease, mainly cholecystectomy, and laparoscopic cholecystectomy has always been considered the gold standard for the treatment of calculous cholecystitis. However, medication, percutaneous transh...