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2019 Vol. 35, No. 10

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Editorial
The development history of new biomarkers for hepatitis B virus infection
Tang Hong
2019, 35(10): 2137-2139. DOI: 10.3969/j.issn.1001-5256.2019.10.001
Abstract(1611) PDF (1960KB)(588) Cited By (7)
Abstract:
The objective of antiviral therapy for chronic hepatitis B is to maximize the long-term inhibition of hepatitis B virus(HBV) replication,reduce hepatocyte inflammation and liver fibrosis,and delay and reduce liver failure,decompensated cirrhosis,hepatocellular carcinoma,and other complications. In a...
Discussions by experts
Clinical application of covalently closed circular DNA detection techniques
Zhang Yu, Zhao JingMin
2019, 35(10): 2140-2144. DOI: 10.3969/j.issn.1001-5256.2019.10.002
Abstract(1910) PDF (2036KB)(530) Cited By (4)
Abstract:
Covalently closed circular DNA(cccDNA) is the original template for hepatitis B virus(HBV) replication and is the basis of persistent HBV infection. Only when HBV cccDNA is completely eliminated can HBV be eradicated. Therefore,the detection of HBV cccDNA plays an important role in evaluating the an...
Application value of serum HBV RNA in clinical management of chronic hepatitis B
Liao Hao, Wang Jie, Lu FengMin
2019, 35(10): 2145-2149. DOI: 10.3969/j.issn.1001-5256.2019.10.003
Abstract(2596) PDF (1908KB)(502) Cited By (14)
Abstract:
Viral hepatitis,liver cirrhosis,and hepatocellular carcinoma caused by hepatitis B virus(HBV) infection still threaten the health of people in China. Efficient antiviral therapy can significantly prevent the progression of liver diseases and reduce the incidence rate of end-stage liver disease,but i...
Serum HBsAg quantification in clinical diagnosis and treatment of chronic hepatitis B
Yu DeMin, Zhang XinXin
2019, 35(10): 2150-2155. DOI: 10.3969/j.issn.1001-5256.2019.10.004
Abstract(1810) PDF (1922KB)(479) Cited By (19)
Abstract:
HBsAg is one of the oldest diagnostic markers for HBV infection,and serum HBsAg level is associated with HBV cccDNA level in hepatocytes,HBV replication capability,and host immune response. In recent years,with the development of serum HBsAg quantification and the concept of functional cure,HBsAg qu...
Clinical significance and application of quantification of hepatitis B core antibody
Yin XueRu, She GeXin, Hou JinLin, Fan Rong
2019, 35(10): 2156-2158. DOI: 10.3969/j.issn.1001-5256.2019.10.005
Abstract(1839) PDF (1889KB)(518) Cited By (6)
Abstract:
Hepatitis B virus(HBV) infection is a global public health problem. Hepatitis B core antibody(anti-HBc) is one of the serum immunological markers in human body after HBV infection. Previous studies have shown that the low serum level of anti-HBc in HBeAg-positive mothers are associated with immunopr...
Hepatitis B virus core-related antigen:A promising new serum marker for hepatitis B virus
Chen EnQiang, Tang Hong
2019, 35(10): 2159-2162. DOI: 10.3969/j.issn.1001-5256.2019.10.006
Abstract(2988) PDF (1892KB)(512) Cited By (11)
Abstract:
Hepatitis B virus core-related antigen(HBcrAg) is a new serum biomarker for hepatitis B virus(HBV) and is composed of several antigens encoded by the pre-C/C region gene of HBV,including HBcAg,HBeAg,and P22 cr precursor protein. There is a poor correlation between HBcrAg and HBsAg and they cannot re...
Guidelines
Consensus on the diagnosis and therapy of hepatic fibrosis(2019)
Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association
2019, 35(10): 2163-2172. DOI: 10.3969/j.issn.1001-5256.2019.10.007
Abstract(2131) PDF (416KB)(1306) Cited By (188)
Abstract:
Diagnosis and treatment standard for hepatitis C virus infection after organ transplantation(2019 edition)
Chinese Society of Organ Transplantation, Chinese Medical Association
2019, 35(10): 2173-2175. DOI: 10.3969/j.issn.1001-5256.2019.10.008
Abstract(245) PDF (192KB)(115) Cited By (1)
Abstract:
In order to further standardize the diagnosis and treatment of hepatitis C virus(HCV) infection after solid organ transplantation(SOT),Chinese Society of Organ Transplantation,Chinese Medical Association,organizes the experts in organ transplantation and infectious diseases to formulate this standar...
Minimally-invasive and multidisciplinary comprehensive diagnosis and treatment for HCC: 2018 Guangzhou consensus
Asia-Pacific Association of Image-Guided Therapy of Oncology, Committee of Minimally Invasive Therapy in Oncology, Chinese Anti-Cancer Association, Asian Conference on Tumor Ablation 2017
2019, 35(10): 2176-2184. DOI: 10.3969/j.issn.1001-5256.2019.10.009
Abstract(1596) PDF (3636KB)(360) Cited By (21)
Abstract:

In China,the vast majority of hepatocellular carcinoma(HCC) is the result of long-term development of hepatitis B and cirrhosis. Pathologically,HCC is characterized by rich blood supply and multicenter origin,with early invasion of small branches of portal vein and intrahepatic metastasis. Therefore...
An excerpt of 2019 WSES guidelines for the management of severe acute pancreatitis
Qin HuiYuan, Kong ZiHao, Yang GuiYuan
2019, 35(10): 2185-2190. DOI: 10.3969/j.issn.1001-5256.2019.10.010
Abstract(1519) PDF (1911KB)(320) Cited By (28)
Abstract:
An excerpt of AGA clinical practice update: Coagulation in cirrhosis (2019)
Hong Cen, Han JuQiang, Qi XingShun
2019, 35(10): 2191-2191. DOI: 10.3969/j.issn.1001-5256.2019.10.011
Abstract(461) PDF (102KB)(167) Cited By (1)
Abstract:
An excerpt of Perioperative hemostatic management in the cirrhotic patient: A position paper on behalf of the Liver Intensive Care Group of Europe (LICAGE) (2019)
He YangLan, Wang YaDong, Qi XingShun
2019, 35(10): 2192-2193. DOI: 10.3969/j.issn.1001-5256.2019.10.012
Abstract(455) PDF (149KB)(153) Cited By (2)
Abstract:
Original articles_Viral hepatitis
Influencing factors for compliance with antiviral therapy with nucleos(t) ide analogues in patients with chronic hepatitis B
Wu XiaoFeng, Li YuFang, Zhang Chi, Zhang LiLi, Ma Ying
2019, 35(10): 2194-2199. DOI: 10.3969/j.issn.1001-5256.2019.10.013
Abstract(658) PDF (285KB)(156) Cited By (21)
Abstract:
Objective To investigate the current status of compliance with antiviral therapy with nucleos(t) ide analogues(NAs) among chronic hepatitis B(CHB) patients treated in General Hospital of Ningxia Medical University. Methods The CHB patients who received antiviral therapy with NAs at the outpatient an...
Influence of sofosbuvir-based antiviral therapy on the expression profile of cytokines and chemokines in patients with chronic hepatitis C
Gao Yi, Liang ZhiJun, Fu Jian
2019, 35(10): 2200-2204. DOI: 10.3969/j.issn.1001-5256.2019.10.014
Abstract(1381) PDF (1917KB)(239) Cited By (8)
Abstract:
Objective To investigate the influence of sofosbuvir-based antiviral therapy on the expression profile of cytokines and chemokines in patients with chronic hepatitis C. Methods A total of 37 previously untreated patients with chronic hepatitis C who visited Department of Infectious Diseases in Haina...
Original articles_Liver fibrosis and liver cirrhosis
Influencing factors for hepatic venous pressure gradient in patients with cirrhotic portal hypertension
Zhou Hao, Yao Xin, Tang ShanHong, Feng ZhiSong, He PingPing, Yin QinQin, Li YunMing, Qin JianPing
2019, 35(10): 2205-2209. DOI: 10.3969/j.issn.1001-5256.2019.10.015
Abstract(1587) PDF (1952KB)(280) Cited By (12)
Abstract:
Objective To investigate the influencing factors for hepatic venous pressure gradient(HVPG) in patients with cirrhotic portal hypertension undergoing transjugular intrahepatic portosystemic shunt(TIPS). Methods A total of 158 patients with cirrhotic portal hypertension who underwent TIPS in The Gene...
TCM syndrome characteristics of portal vein thrombosis in patients with liver cirrhosis and related risk factors
Lyu Jing, Dong SiSi, Gu HongTu, Zhao ZhangQing, Liu ChengHai
2019, 35(10): 2210-2213. DOI: 10.3969/j.issn.1001-5256.2019.10.016
Abstract(1751) PDF (1902KB)(256) Cited By (18)
Abstract:

Objective To investigate the traditional Chinese medicine(TCM) syndrome characteristics of portal vein thrombosis(PVT) in patients with liver cirrhosis and related risk factors. Methods A total of 62 patients with liver cirrhosis and PVT who were hospitalized in Shuguang Hospital Affiliated to Shang...
Original articles_Liver neoplasms
Value of contrast-enhanced computed tomography and magnetic resonance imaging in diagnosis of residual or recurrent lesion after transcatheter arterial chemoembolization in hepatocellular carcinoma:A Meta-analysis
Li Dong, Luo TianYang, Ran YaWei
2019, 35(10): 2214-2219. DOI: 10.3969/j.issn.1001-5256.2019.10.017
Abstract(689) PDF (1323KB)(141) Cited By (7)
Abstract:
Objective To systematically evaluate the value of contrast-enhanced computed tomography(CECT) and contrast-enhanced magnetic resonance imaging(CEMRI) in the diagnosis of residual or recurrent lesion after transcatheter arterial chemoembolization(TACE)in hepatocellular carcinoma(HCC). Methods Pub Med...
Clinical effect of microwave ablation combined with transcatheter arterial chemoembolization in treatment of primary hepatocellular carcinoma with portal vein tumor thrombus and related influencing factors
Zhou ChuanLi, Tian ShiChao, Chen XiaoLi, Huang Jin, Zhang XianPing, Zhang XueYan, Xu YaJi
2019, 35(10): 2220-2224. DOI: 10.3969/j.issn.1001-5256.2019.10.018
Abstract(1616) PDF (1951KB)(290) Cited By (10)
Abstract:
Objective To investigate the clinical effect of microwave ablation(MWA) combined with transcatheter arterial chemoembolization(TACE) in the treatment of primary hepatocellular carcinoma(PHC) with portal vein tumor thrombus(PVTT) and related influencing factors. Methods A total of 92 patients with PH...
Establishment and verification of a nomogram for predicting patient prognosis after hepatectomy for hepatocellular carcinoma
Zang YouYa, Long PeiYun, Han ZhiWei, Wang Huan, Ruan JingSheng, Huang Shan, Wu GuoBin, Chen Chuang
2019, 35(10): 2225-2230. DOI: 10.3969/j.issn.1001-5256.2019.10.019
Abstract(1428) PDF (2444KB)(265) Cited By (4)
Abstract:
Expression and clinical significance of ZNF580 mRNA in hepatocellular carcinoma: An analysis based on The Cancer Genome Atlas database
Mao Jun, Li RenLi, Li Hai, Xia ShiHai, Zhang WenCheng, Xiang XiaoHui
2019, 35(10): 2231-2235. DOI: 10.3969/j.issn.1001-5256.2019.10.020
Abstract(1368) PDF (2216KB)(252)
Abstract:

Objective To establish and validate a nomogram for overall survival(OS) of patients after hepatectomy for hepatocellular carcinoma(HCC). Methods A retrospective analysis was performed for the clinical data of 1013 patients who underwent hepatectomy for HCC in The Affiliated Tumor Hospital of Guangxi...
Original articles_Biliary diseases
Value of serum carbohydrate antigeng 19-9 combined with procalcitonin in the diagnosis of acute cholangitis secondary to common bile duct stones
Wu Di, Lu ZhongYi, Tang ZhongLing, He XueYan, Wang Jun
2019, 35(10): 2236-2239. DOI: 10.3969/j.issn.1001-5256.2019.10.021
Abstract(1317) PDF (2144KB)(268) Cited By (8)
Abstract:
Objective To investigate the value of serum carbohydrate antigen 19-9(CA19-9) combined with procalcitonin(PCT) in the diagnosis of acute cholangitis secondary to common bile duct stones. Methods A retrospective analysis was performed for the clinical data of764 patients with common bile duct stones ...
Original articles_Pancreatic diseases
Clinical and prognostic features of children with acute pancreatitis:A retrospective analysis of 105 cases
Zhong Rui, Xu Huan, Peng Yan, Yan YongFeng, Jiang Xin, Wang Min, Fu WenGuang, Tang XiaoWei
2019, 35(10): 2240-2245. DOI: 10.3969/j.issn.1001-5256.2019.10.022
Abstract(1604) PDF (2157KB)(233) Cited By (16)
Abstract:
Objective To investigate the etiology and clinical features of acute pancreatitis(AP) in children. Methods A total of 105 children with AP who were admitted to The Affiliated Hospital of Southwest Medical University from January 2013 to December 2018 were enrolled,and according to the severity of AP...
Value of contrast-enhanced endoscopic ultrasonography in the differential diagnosis of mass-type chronic pancreatitis and pancreatic cancer:A Meta-analysis
Wang Le, Liu LiXin, Guo XiaoHong
2019, 35(10): 2246-2251. DOI: 10.3969/j.issn.1001-5256.2019.10.023
Abstract(1397) PDF (2384KB)(240) Cited By (8)
Abstract:
Objective To systematically evaluate the value of contrast-enhanced endoscopic ultrasonography(CE-EUS) in the differential diagnosis of mass-type chronic pancreatitis and pancreatic cancer. Methods CNKI,Wanfang Data,CBM,PubMed,Embase,and the Cochrane Library were searched for Chinese and English art...
Original articles_Others
Effect of the liver-regulating and spleen-strengthening method on the expression of Toll-like receptor 4 and occludin in the intestinal mucosa of rats with nonalcoholic fatty liver disease
Chen RuiLin, Shen QingYan, Niu KeMin, Yang ZhongTing, Yin XiuWen, Li Xue, Zhou Tao, Chen Jing, Wei BeiHai
2019, 35(10): 2252-2256. DOI: 10.3969/j.issn.1001-5256.2019.10.024
Abstract(1117) PDF (2562KB)(218) Cited By (6)
Abstract:

Objective To investigate the effect of the liver-regulating and spleen-strengthening method on the expression of Toll-like receptor 4(TLR4) and occludin in the intestinal mucosal barrier of rats with nonalcoholic fatty liver disease(NAFLD) induced by high-fat and high-sugar diet. Methods A total of ...
Effect on JNK1 gene silencing on the expression of high-molecular-weight adiponectin in mice with nonalcoholic fatty liver disease
Zhao XiaoFang, Tang YouMing, Xu XinJie, Tang YanFang, Liu XuDong, Lu: Ping, Zhao ZhuangZhi
2019, 35(10): 2257-2260. DOI: 10.3969/j.issn.1001-5256.2019.10.025
Abstract(1390) PDF (2186KB)(237) Cited By (5)
Abstract:

Objective To investigate the effect of JNK1 gene silencing on the expression of high-molecular-weight adiponectin and related pathway molecules in adipose tissue of mice with nonalcoholic fatty liver disease(NAFLD). Methods A total of 20 C57 BL/6 mice were randomly divided into normal group,model co...
Effect of rapamycin on the expression of autophagy-related proteins Unc-51 like autophagy activating kinase 1 and microtubule-associated protein 1 light chain 3 in hepatic ischemia-reperfusion injury and its significance
Yang LongCan, Zhang XuYang, Pan NingBo, Yu Xi, Li JiWei, Zhang Ying
2019, 35(10): 2261-2265. DOI: 10.3969/j.issn.1001-5256.2019.10.026
Abstract(739) PDF (2070KB)(305) Cited By (7)
Abstract:

Objective To investigate the effect of rapamycin on the expression of the autophagy-related proteins Unc-51 like autophagy activating kinase 1(ULK1) and microtubule-associated protein 1 light chain 3(LC3) in hepatic ischemia-reperfusion injury and its significance. Methods A total of 30 rats were di...
Efficacy and safety of norepinephrine combined with albumin versus terlipressin combined with albumin in treatment of type 1 hepatorenal syndrome:A Meta-analysis
Tan YanXin, Long FuLi, Mao DeWen, Zhang JianLing, Ma YuZhen, Yan LianJie
2019, 35(10): 2266-2271. DOI: 10.3969/j.issn.1001-5256.2019.10.027
Abstract(1592) PDF (2481KB)(244) Cited By (10)
Abstract:

Objective To systematically review the efficacy and safety of norepinephrine combined with albumin versus terlipressin combined with albumin in the treatment of type 1 hepatorenal syndrome(HRS1). Methods Pub Med,EMBASE,Medline,Cochrane Library,CNKI,Wanfang Data,and VIP were searched for comparative ...
A bioinformatics analysis of differentially expressed genes in Huh7 cells with low expression of Mindin
Zhang Xin, Wang MuQi, Wang WenJun, Li YaPing, Shi JuanJuan, Li Mei, Jia XiaoLi, Dang ShuangSuo
2019, 35(10): 2272-2277. DOI: 10.3969/j.issn.1001-5256.2019.10.028
Abstract(1206) PDF (3451KB)(239)
Abstract:

Objective To perform a transcriptomic study of Huh7 cells with low expression of Mindin,and to investigate the biological effects of Mindin. Methods The Mindin interference sequence was designed,synthesized,and introduced into Huh7 cells via the lentiviral vector GV248. Real-time quantitative PCR wa...
Efficacy and safety of different surgical procedures in treatment of primary splenic hydatid cysts
Talaiti·Tuergan, Zhang RuiQing, Shao YingMei, Ran Bo, Jiang TieMin, Tuerganaili·Aji
2019, 35(10): 2278-2280. DOI: 10.3969/j.issn.1001-5256.2019.10.029
Abstract(1293) PDF (1881KB)(229) Cited By (4)
Abstract:

Objective To investigate the safety and efficacy of splenectomy versus spleen-preservation surgery(endocystectomy or subtotal pericystectomy) in the treatment of primary splenic hydatid cysts,and to determine the optimal surgical procedure for this disease. Methods A retrospective analysis was perfo...
Clinical effect of robotic versus laparoscopic splenectomy in treatment of nontraumatic splenic diseases:A Meta-analysis
Lai Li, Peng FangYi, Su Song, Fang Cheng, Zhang MengYu, He Kai, Li Bo, He Pan, Xia XianMing
2019, 35(10): 2281-2285. DOI: 10.3969/j.issn.1001-5256.2019.10.030
Abstract(1372) PDF (2568KB)(240) Cited By (3)
Abstract:

Objective To investigate the clinical effect and safety of robotic versus laparoscopic splenectomy in the treatment of nontraumatic splenic diseases. Methods According to the inclusion and exclusion criteria,PubMed,Web of Science,Embase,Cochrane Library,CBM,CNKI,Wanfang Data,and VIP were systematica...
Brief reports
Diagnosis and treatment of intrahepatic biliary papillary mucinous cystadenoma:A report of 6 cases
Chen JiaJun, Zhang HaiYang, Cao XueDong, Qu Yan, Luo YunQuan
2019, 35(10): 2286-2288. DOI: 10.3969/j.issn.1001-5256.2019.10.031
Abstract(1111) PDF (2092KB)(225) Cited By (1)
Abstract:
Case reports
A case of recurrent fever and lumbago in hepatic cirrhosis complicated by spontaneous bacterial peritonitis
Xue ShuWen, Zhao QianShu, Li XiaoKe, Yang QianQian, Zhou Qi, Guo XiaoLin, Ji HuiFan
2019, 35(10): 2289-2291. DOI: 10.3969/j.issn.1001-5256.2019.10.032
Abstract(1241) PDF (1945KB)(302) Cited By (3)
Abstract:
Autoimmune hepatitis with subacute liver failure as the initial manifestation:A case report
Lu LingLing, Zhang Hui, Geng AiWen, Xiao Li, Xian JianChun, Qi ChuanWang
2019, 35(10): 2292-2294. DOI: 10.3969/j.issn.1001-5256.2019.10.033
Abstract(1304) PDF (2056KB)(262) Cited By (1)
Abstract:
Diagnosis and treatment of adult Alagille syndrome:A case report
Ping DaBing, Liu HongLiang, Hu XuDong, Yuan JiLi, Liu ChengHai
2019, 35(10): 2295-2297. DOI: 10.3969/j.issn.1001-5256.2019.10.034
Abstract(1131) PDF (2121KB)(258)
Abstract:
Pancreatic panniculitis:A case report
Chen Hao, Qian BaoLin, Wang AnKang, Yang DaYin, Jiang Yu, Ye MingXin, Li Qiu, He YuanMin, Fu WenGuang
2019, 35(10): 2298-2299. DOI: 10.3969/j.issn.1001-5256.2019.10.035
Abstract(1099) PDF (2070KB)(245) Cited By (3)
Abstract:
A case of giant paraganglioma of the pancreas
Xu HongJi, Li XinXin, Liu Kai
2019, 35(10): 2300-2301. DOI: 10.3969/j.issn.1001-5256.2019.10.036
Abstract(1189) PDF (2003KB)(240) Cited By (3)
Abstract:
Reviews
Research advances in anti-hepatitis B virus drugs
Cai MengZhi, Qin Gang
2019, 35(10): 2302-2307. DOI: 10.3969/j.issn.1001-5256.2019.10.037
Abstract(1761) PDF (2093KB)(439) Cited By (9)
Abstract:
Hepatitis B virus(HBV) infection has always been a great threat to public health,and about 2 billion people in the world have the history of HBV infection. Chronic HBV infection can lead to chronic hepatitis,liver cirrhosis,and even hepatocellular carcinoma. At present,nucleoside analogues(NAs) and ...
Application of terlipressin in the treatment of esophagogastric variceal bleeding in liver cirrhosis
Li XiaoLu, Li Lei
2019, 35(10): 2308-2311. DOI: 10.3969/j.issn.1001-5256.2019.10.038
Abstract(649) PDF (231KB)(163) Cited By (7)
Abstract:
Esophagogastric variceal bleeding(EVB) is a common fatal complication secondary to cirrhotic portal hypertension. Terlipressin can shrink visceral blood vessels,reduce portal pressure,and increase renal perfusion and is mainly used in the treatment of EVB. This article summarizes the mechanism of ac...
Research advances in interventional treatment of cirrhotic portal hypertension
Zhang Xue, Xu Ying, Zou SongLong, Wu JieFang, Meng ShuHui
2019, 35(10): 2312-2315. DOI: 10.3969/j.issn.1001-5256.2019.10.039
Abstract(1170) PDF (1903KB)(281) Cited By (4)
Abstract:
Portal hypertension is one of the main clinical manifestations of decompensated cirrhosis. A series of complications due to cirrhotic portal hypertension,such as esophagogastric variceal bleeding,hypersplenism,and intractable ascites,greatly threaten human health.Since the application of the radiolo...
Role and mechanism of ferroptosis in treatment of liver cancer with sorafenib
Chen Xiang, Wen DiGuang, You Yu, Gong JianPing
2019, 35(10): 2316-2319. DOI: 10.3969/j.issn.1001-5256.2019.10.040
Abstract(2526) PDF (1980KB)(404) Cited By (12)
Abstract:
Patients with advanced liver cancer have poor basic conditions and poor prognosis due to limited treatment options. Sorafenib is the first-line drug approved by FDA for the treatment of advanced liver cancer,and it has multi-kinase inhibitory activity and can improve the survival time of patients wi...
Value of Sal-like 4 in the diagnosis and treatment of primary liver cancer
Shao YueMing, Zhang Yu, Yin Xin, Wen XiaoYu
2019, 35(10): 2320-2323. DOI: 10.3969/j.issn.1001-5256.2019.10.041
Abstract(1332) PDF (2063KB)(247) Cited By (8)
Abstract:
Sal-like 4(SALL4) is a transcription factor that helps to maintain self-renewal and pluripotency of stem cells. This gene is expressed in the human fetal liver,but is silent in the healthy adult liver. It has been reported that SALL4 has a diagnostic value in a variety of solid tumors. These charact...
Association between nonalcoholic fatty liver disease and dietary inflammation index and its practical significance
Guo Yan, Huang Li, Yang GuoChao, Liu Shan, Du LinNa, Wang MinJuan
2019, 35(10): 2324-2326. DOI: 10.3969/j.issn.1001-5256.2019.10.042
Abstract(1289) PDF (1896KB)(250) Cited By (2)
Abstract:
In recent years,the incidence rate of nonalcoholic fatty liver disease(NAFLD) keeps increasing,and the age of onset gradually becomes younger. Unhealthy lifestyle,including bad dietary choices,is one of the major causes of NAFLD. However,there are still no clear treatment regimens for NAFLD,and life...
Role of circadian clock genes in the development and progression of nonalcoholic fatty liver disease
Ai Yan, Yang XiaoQian, Pan XiaoLi, Ye Jin
2019, 35(10): 2327-2330. DOI: 10.3969/j.issn.1001-5256.2019.10.043
Abstract(956) PDF (1906KB)(301) Cited By (6)
Abstract:
Circadian clock is an inherent biological rhythm of organism which forms in the long process of evolution to adapt to the changes in light and temperature due to day-night alternation. Circadian clock in humans is accurately regulated by various circadian clock genes at the molecular level and are h...
Advances in the clinical treatment of autoimmune hepatitis
Jin Chao, Pan JieLu, Yu Xiao, Zhang HaiYan, Xing LianJun
2019, 35(10): 2331-2334. DOI: 10.3969/j.issn.1001-5256.2019.10.044
Abstract(1442) PDF (1961KB)(261) Cited By (11)
Abstract:
Autoimmune hepatitis(AIH) is an autoimmune-mediated chronic progressive liver inflammatory disease with unknown pathogenesis. The main purpose of AIH treatment at present is to relieve symptoms,improve liver function and pathological abnormalities,and slow down the progression to liver fibrosis. Eas...
Research advances in the pathogenesis of autoimmune hepatitis
Cao YiNan, Zhou GuiQin, Wang XianBo, Li Bin, Feng Ying, Hu ChaoQun
2019, 35(10): 2335-2338. DOI: 10.3969/j.issn.1001-5256.2019.10.045
Abstract(1074) PDF (1917KB)(296) Cited By (19)
Abstract:
Autoimmune hepatitis(AIH) is a progressive chronic inflammatory liver disease with unknown etiology. At present,genetic susceptibility and environmental factors are universally recognized as the etiological factors for AIH. With the deepening of research in recent years,other etiological factors,suc...
Role of autoimmune ecological factors in the pathogenesis of autoimmune hepatitis
Chen Jie, Huang ChunYang, Dan Jing, Liu YanMin
2019, 35(10): 2339-2341. DOI: 10.3969/j.issn.1001-5256.2019.10.046
Abstract(1332) PDF (1890KB)(245) Cited By (6)
Abstract:
Autoimmune hepatitis(AIH) is a chronic liver inflammatory disease with unknown etiology,and at present,both genetic and environmental factors are thought to be involved in the pathogenesis of AIH. Environmental exposure has an important impact on the development of AIH. Autoimmune ecology is the stu...
Advances in research and application of liver organoids
Wang Li, Qiu YiLing, Wang JianShe
2019, 35(10): 2342-2345. DOI: 10.3969/j.issn.1001-5256.2019.10.047
Abstract(1768) PDF (1897KB)(428) Cited By (5)
Abstract:
Liver diseases significantly affect human health. Classic research models cannot maintain hepatocyte polarity for a long time and have a different genetic background from normal human hepatocytes,which limits the research on the physiological functions of hepatocytes and the mechanisms of related di...
Role of NLRP3 inflammasome in the development and progression of liver diseases
Ye QianLing, Mao DeWen, Wang MingGang, Wang Na
2019, 35(10): 2346-2350. DOI: 10.3969/j.issn.1001-5256.2019.10.048
Abstract(1014) PDF (1925KB)(223) Cited By (5)
Abstract:
Immune cascade due to inflammasome has become a research hotspot in recent years,and the role of NLRP3 inflammasome in the development and progression of liver diseases has attracted more and more attention. This article analyzes the action characteristics and regulatory mechanism of NLRP3 inflammas...
Research advances in the role and mechanism of peroxisome proliferator-activated receptor alpha in liver diseases
Zhang Dan, Ma LanQing
2019, 35(10): 2351-2354. DOI: 10.3969/j.issn.1001-5256.2019.10.049
Abstract(2263) PDF (238KB)(492) Cited By (11)
Abstract:
Peroxisome proliferator-activated receptor alpha(PPARα) is a member of the nuclear receptor superfamily and plays a central regulatory role in lipid metabolism. Recent studies have found that PPARα agonists play a key role in the prevention and treatment of nonalcoholic fatty liver disease,which has...
Research advances in the mechanism of action of intestinal microecology in intrahepatic cholestasis
Huang Qian, Zhang HaiBo, Li JingTao, Wei HaiLiang, Yan ShuGuang, Hui Yi, Chang ZhanJie
2019, 35(10): 2355-2359. DOI: 10.3969/j.issn.1001-5256.2019.10.050
Abstract(1171) PDF (2562KB)(330) Cited By (16)
Abstract:
Intrahepatic cholestasis(IHC) is a dysfunction of bile production,secretion,and excretion caused by various factors including genetics,immunity,inflammation,stones,and tumors,and therefore,the bile is not normally discharged into the duodenum and reversely flows into blood,which causes a series of c...
Development and enlightenment of intelligentized diagnostic and therapeutic mode for hepatobiliary tumors
Wang XiaoYun, Li LinFeng, Guo Quan, Ceng YiLan, Li HaiYang, Du YingRong, Chen Gang, Liang YueDong, Lu YinYing
2019, 35(10): 2360-2364. DOI: 10.3969/j.issn.1001-5256.2019.10.051
Abstract(1398) PDF (2074KB)(288) Cited By (12)
Abstract:
Clinical decision support system(CDSS) and multidisciplinary team(MDT) are important measures to improve the efficiency and quality of healthcare service. This article reviews and analyzes the current status of the development of CDSS and MDT in China and foreign countries and summarizes their featu...
Role of adenosine monophosphate-activated protein kinase in acute pancreatitis
Huang Lei, Zhao XianLin, Wang MingHao, Wang XiaoXiang
2019, 35(10): 2365-2368. DOI: 10.3969/j.issn.1001-5256.2019.10.052
Abstract(1265) PDF (2016KB)(200) Cited By (2)
Abstract:
Adenosine monophosphate-activated protein kinase(AMPK) is a critical enzyme for energy and metabolic regulation and can effectively maintain the homeostasis of energy and metabolism in cells and the body,and thus it plays an important role in both health and diseases. Current studies have shown that...
    

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