中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

2019 Vol. 35, No. 11

Display Method:
Editorial
Development and innovation of liver transplantation in China
Shen ZhongYang
2019, 35(11): 2377-2385. DOI: 10.3969/j.issn.1001-5256.2019.11.001
Abstract:
After 20 years of rapid development,liver transplantation in China has become an important part of this field in the world. In response to hepatitis B-associated liver disease and liver cancer,China has issued the guidelines and standards for liver transplantation in line with our own national condi...
Discussions by experts
Tasks and strategies for the prevention and treatment of middle-and long-term complications after liver transplantation
Liu YiHe, Zheng Hong, Shen ZhongYang
2019, 35(11): 2386-2390. DOI: 10.3969/j.issn.1001-5256.2019.11.002
Abstract:
With the continuous improvement of liver transplantation techniques and the innovation of related disciplines,great changes have been observed in the etiology and clinical outcome of middle-and long-term complications after liver transplantation,and thus related prevention and treatment strategies a...
Risk factors for tumor recurrence after liver transplantation for hepatocellular carcinoma and related control strategies
Zheng WeiPing, Shen ZhongYang
2019, 35(11): 2391-2395. DOI: 10.3969/j.issn.1001-5256.2019.11.003
Abstract:
Tumor recurrence after liver transplantation for hepatocellular carcinoma is the main cause of significant reductions in the survival rates of patients and grafts. Risk factors for tumor recurrence after liver transplantation include pathological and biological features,factors associated with the r...
An analysis of related issues in long-term survival in children after liver transplantation
Lu YeFeng, Xia Qiang, Qiu BiJun, Feng MingXuan, Wan Ping
2019, 35(11): 2396-2401. DOI: 10.3969/j.issn.1001-5256.2019.11.004
Abstract:
Liver transplantation is a mature treatment for children with end-stage liver disease. With the development of surgical techniques,immunosuppressive therapy,and infection monitoring in recent years,there have been significant increases in the survival rates of patients and liver transplants,helping ...
Research advances in immune tolerance in children receiving liver transplantation
Wang Kai, Gao Wei
2019, 35(11): 2402-2407. DOI: 10.3969/j.issn.1001-5256.2019.11.005
Abstract:
Compared with adult recipients,pediatric liver transplantation recipients have urgent needs for immune tolerance,with a higher probability of successful realization of immune tolerance. However at present,there is still a lack of effective experimental regimens,immune monitoring methods,and graft hi...
Guidelines
Chinese guidelines on the management of liver cirrhosis
Chinese Society of Hepatology, Chinese Medical Association
2019, 35(11): 2408-2425. DOI: 10.3969/j.issn.1001-5256.2019.11.006
Abstract(3870) PDF (2168KB)(2167)
Abstract:
Expert recommendations on standardized diagnosis and treatment for fatty liver disease (2019 revised edition)
Committee of Hepatology, Chinese Research Hospital Association, Fatty Liver Expert Committee, Chinese Medical Doctor Association, National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, National Workshop on Liver and Metabolism, Chinese Society of Endocrinology, Chinese Medical Association
2019, 35(11): 2426-2430. DOI: 10.3969/j.issn.1001-5256.2019.11.007
Abstract(1889) PDF (244KB)(1015)
Abstract:

Nonalcoholic fatty liver disease( NAFLD) is the most common liver disease in China. To provide evidence-based and updated practical recommendations for clinician,this expert recommendations have updated the diagnosis and treatment of NAFLD in five aspects as follows:( 1) the framework of NAFLD treat...

Guidelines for the diagnosis and treatment of hepatoblastoma (2019)
Compilation and Examination Expert Group for Guidelines for the diagnosis and treatment of hepatoblastoma (2019)
2019, 35(11): 2431-2434. DOI: 10.3969/j.issn.1001-5256.2019.11.008
Abstract:
Guidelines for diagnosing & treating biliary atresia (2018 Edition)
Section of Hepatobiliary Surgery, Branch of Pediatric Surgery, Chinese Medical Association, Section of Pediatric Hepatic Transplantation, Branch of Organ Transplantation, Chinese Medical Doctor Association
2019, 35(11): 2435-2440. DOI: 10.3969/j.issn.1001-5256.2019.11.009
Abstract(1017) PDF (273KB)(839)
Abstract:
Expert recommendation for operational norms of laparoscopic radical resection of perihilar cholangiocarcinoma
The Expert Group on Operational Norms of Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma, Editorial Board of Chinese Journal of Surgery
2019, 35(11): 2441-2446. DOI: 10.3969/j.issn.1001-5256.2019.11.010
Abstract:

Radical resection is the only curable treatment for perihilar cholangiocarcinoma. With the continuous renewal of laparoscopic instruments and the continuous improvement of technology,laparoscopic radical resection of perihilar cholangiocarcinoma has been gradually carried out in China,and its feasib...

Recommendations for diagnosis and treatment of alcohol-related liver diseases: 2019 practice guidance from the American Association for the Study of Liver Diseases
Li ZhiGuo, Zhu Shun, Li Shuo, Ye YongAn
2019, 35(11): 2447-2448. DOI: 10.3969/j.issn.1001-5256.2019.11.011
Abstract:
Original articles_Viral hepatitis
Change in the level of T-cell receptor rearrangement excision circles after antiviral therapy in patients with chronic hepatitis B
Xiong Fang, Ma YanPin, Bao XuLi, Lu: Jun
2019, 35(11): 2449-2452. DOI: 10.3969/j.issn.1001-5256.2019.11.012
Abstract:
Objective To investigate the change in the level of T-cell receptor rearrangement excision circles( TREC) after antiviral therapy with thymopentin( TP5) and entecavir( ETV) in HBeAg-positive chronic hepatitis B( CHB) patients. Methods A total of 30 HBeAg-positive CHB patients who were diagnosed and ...
Value of cystatin C in the diagnosis of early renal injury in patients with viral hepatitis
Zhu YaGe, Wang Jing, Liu JinFeng, He YingLi
2019, 35(11): 2453-2455. DOI: 10.3969/j.issn.1001-5256.2019.11.013
Abstract:
Objective To investigate the value of serum cystatin C( Cys C) in the diagnosis of early renal injury in patients with viral hepatitis. Methods A retrospective analysis was performed for the clinical data of 270 patients with chronic hepatitis B virus( HBV) or hepatitis C virus( HCV) infection. Acco...
Clinical features of hepatitis C patients with failure or recurrence after treatment with pegylated interferon-α combined with ribavirin and the clinical effect of direct-acting antiviral agents
Zhang YaoDi, Zhang YueRong, Wang Hui, Lin Yan, Zhou Ning, Wu LiYang, Wei ShiFang, Li XiangLin
2019, 35(11): 2456-2460. DOI: 10.3969/j.issn.1001-5256.2019.11.014
Abstract:
Objective To investigate the clinical features of patients with failure or recurrence after treatment with PEG-IFN combined with ribavirin( PR regimen) in the real world and the clinical effect of different direct-acting antiviral agent( DAA) regimens in such patients. Methods A retrospective analys...
Original articles_Liver fibrosis and liver cirrhosis
Correlation of the levels of angiotensin Ⅱ and angiotensin (1-7) with the degree of chronic hepatitis B liver fibrosis
Yu Chong, Gu YuLing, Li Min, Gu ErLi
2019, 35(11): 2461-2465. DOI: 10.3969/j.issn.1001-5256.2019.11.015
Abstract:
Objective To investigate the differences in the plasma levels of angiotensin Ⅱ( Ang Ⅱ) and angiotensin( 1-7) [Ang( 1-7) ]in different stages among patients with chronic hepatitis B( CHB) liver fibrosis and their significance in the pathogenesis of liver fibrosis.Methods A prospective study was perfo...
Value of serum liver fibrosis markers in the diagnosis of liver fibrosis
Zhang Yu, Tang ShiXiao
2019, 35(11): 2466-2471. DOI: 10.3969/j.issn.1001-5256.2019.11.016
Abstract:
Objective To investigate the value of the four serum liver fibrosis markers,i. e.,procollagen Ⅲ( PCⅢ),type Ⅳ collagen( C-Ⅳ),hyaluronic acid( HA),and laminin( LN),in the diagnosis of liver fibrosis. Methods A retrospective analysis was performed for the clinical data of 155 patients with liver cirrho...
Establishment of a predictive model of death within 30 days for patients with liver cirrhosis and bacterial ascites
Huang YunYi, Wang XianBo
2019, 35(11): 2472-2477. DOI: 10.3969/j.issn.1001-5256.2019.11.017
Abstract:
Objective To investigate the risk factors for death within 30 days in patients with liver cirrhosis and bacterial ascites,and to establish a predictive model of death within 30 days. Methods A retrospective analysis was performed for the clinical data of 86 patients with liver cirrhosis and bacteria...
Influence of alcohol consumption on liver function and rebleeding in alcoholic cirrhotic patients with esophageal and gastric varices
Ma JiaLi, He LingLing, Li Ping, Jiang Yu, Hu JuLong, Zhou YuLing, Liang XiuXia, Wei HongShan
2019, 35(11): 2478-2482. DOI: 10.3969/j.issn.1001-5256.2019.11.018
Abstract:
Objective To investigate the influence of alcohol consumption on liver function and prognosis in alcoholic cirrhotic patients.Methods A total of 211 alcoholic cirrhotic patients with gastroesophageal variceal bleeding who underwent endoscopic treatment in Beijing Ditan Hospital,Capital Medical Unive...
Effect of Hic-5 gene knockout on NF-κB/p65 expression and CCl4-induced liver fibrosis degree in mice
Yang DaYin, Du YiChao, Tan Peng, Chen Hao, Qian BaoLin, Wang AnKang, Huang ShiYao, Fu WenGuang, Xia XianMing
2019, 35(11): 2483-2488. DOI: 10.3969/j.issn.1001-5256.2019.11.019
Abstract:

Objective To investigate the effect of Hic-5 gene knockout on NF-κB/p65 expression and liver fibrosis. Methods Ten wild-type male C57 BL/6 mice were randomly divided into wild-type control group( WT-Control group with 5 mice) and wild-type experimental group( WT-CCl4 group with 5 mice),and ten male ...

Original articles_Liver neoplasms
Efficacy and safety of microsphere transarterid chemoembolization combined with radiotherapy versus microsphere transarterial chemoembolization alone in treatment of patients with unresectable liver cancer
Ma MingYuan, Lin GangYi, Cai ZongYang, Luo HeSan, Wu ShengXi
2019, 35(11): 2489-2494. DOI: 10.3969/j.issn.1001-5256.2019.11.020
Abstract:
Objective To investigate the efficacy and safety of microsphere transarterial chemoembolization( TACE) combined with radiotherapy in the treatment of patients with unresectable liver cancer. Methods A total of 68 patients with unresectable liver cancer were enrolled in Shantou central hospital from ...
Clinical effect of Jinlong capsules combined with Western medicine treatment in treatment of primary liver cancer:A Meta-analysis
Shi Ke, Wang XiaoJing, Wang XianBo
2019, 35(11): 2495-2501. DOI: 10.3969/j.issn.1001-5256.2019.11.021
Abstract:
Objective To investigate the clinical effect and adverse events of Jinlong capsules combined with Western medicine treatment in the treatment of advanced primary liver cancer. Methods PubMed,The Cochrane library,CNKI,Wanfang Data,CBM,and VIP were searched for randomized controlled trials( RCTs) on J...
Value of conventional ultrasonography and contrast-enhanced ultrasound in the differential diagnosis of intrahepatic cholangiocellular carcinoma and hepatocellular carcinoma: An analysis based on the logistic regression model
Ye XianJun, Hu Lei, He NianAn, Wei Mei, Liu Xiao, Liu WenBin
2019, 35(11): 2502-2507. DOI: 10.3969/j.issn.1001-5256.2019.11.022
Abstract:
Objective To investigate the value of conventional ultrasonography( US) and contrast-enhanced ultrasound( CEUS) in the differential diagnosis of intrahepatic cholangiocellular carcinoma( ICC) and hepatocellular carcinoma( HCC) by establishing a logistic regression model with the variables of US feat...
Expression of FAM134B in liver cancer and its association with prognosis: An analysis based on data mining
Zhong LanHai, Ma DanDan, Zhang ZhiYong, Zhang Yi, Cai Xun
2019, 35(11): 2508-2512. DOI: 10.3969/j.issn.1001-5256.2019.11.023
Abstract:
Objective To investigate the expression of FAM134 B in liver cancer and its association with clinicopathological features and prognosis. Methods Data mining was performed for Oncomine,Human Protein Atlas,TCGA,and Kaplan Meier-Plotter databases to analyze the expression of FAM134 B in liver cancer,an...
Expression and significance of the LONP1 gene in hepatocellular carcinoma
Zhang Yan, Xiang XiaoXing, Wang CuiMei
2019, 35(11): 2513-2516. DOI: 10.3969/j.issn.1001-5256.2019.11.024
Abstract:
Objective To investigate the expression and clinical significance of the LONP1 gene in hepatocellular carcinoma( HCC).Methods A total of 90 patients with pathologically confirmed HCC from January 2010 to September 2011 were enrolled,and the microarrays for their HCC tissue and adjacent tissue sample...
Original articles_Biliary diseases
Association between fasting blood glucose and the risk of cholelithiasis
Liang MingYang, Wei YaoChen, Wang YiMing, Cui HaoZhe, Sun MiaoMiao, Liu SiQing, Cao LiYing
2019, 35(11): 2517-2522. DOI: 10.3969/j.issn.1001-5256.2019.11.025
Abstract:
Objective To investigate the association between fasting blood glucose and the risk of cholelithiasis. Methods A total of87513 individuals who underwent fasting blood glucose test and liver/biliary ultrasound in health examination in Kailuan from 2006 to 2007 were enrolled as subjects,and according ...
Clinicopathological features of Caroli's disease: An analysis of 5 cases
Li Li, Yao JingJing, Yang JiangHui, Yin HongFang
2019, 35(11): 2523-2527. DOI: 10.3969/j.issn.1001-5256.2019.11.026
Abstract:
Objective To investigate the clinical features,pathological features,differential diagnosis,and prognosis of Caroli's disease( CD). Methods A retrospective analysis was performed for the clinicopathological data of 5 parents with CD who were treated in Beijing Tsinghua Chang Gung Hospital from Janua...
Original articles_Pancreatic diseases
Clinical and prognostic features of acute alcoholic pancreatitis
Jiang Xin, Xu Huan, Yan YongFeng, Zhong Rui, Luo XuJuan, Shi XiaoMin, Wang Min, Peng Yan, Tang XiaoWei
2019, 35(11): 2528-2532. DOI: 10.3969/j.issn.1001-5256.2019.11.027
Abstract:
Objective To investigate the clinical and prognostic features of acute alcoholic pancreatitis. Methods A total of 467 patients with incipient acute pancreatitis( AP) who were admitted to The Affiliated Hospital of Southwest Medical University from July 2013 to July2018 were enrolled as subjects,and ...
Effect of UHRF1 gene silencing on the progression of pancreatic adenocarcinoma cells
Yan Ping, Wang Qing, Liu Yu, Wu Yan, He Shuai, Chen Xia
2019, 35(11): 2533-2536. DOI: 10.3969/j.issn.1001-5256.2019.11.028
Abstract:
Objective To investigate the effect of UHRF1 gene silencing on the progression of pancreatic adenocarcinoma( PAAD) cells.Methods A total of 30 patients with PAAD who underwent pancreaticoduodenectomy in Department of Hepatobiliary Surgery,Leshan People's Hospital,from July to December,2018,were enro...
Original articles_Others
Clinical features of diabetic patients with bacterial liver abscess and different levels of glycosylated hemoglobin
Wang WeiZhao, Zhu QinLing, Xiang XiaoXing, Ma Li, Ju MengXian, Jin XiaoLong, Wang YongChao, Han WeiWei, Xu QingCheng
2019, 35(11): 2537-2541. DOI: 10.3969/j.issn.1001-5256.2019.11.029
Abstract:

Objective To investigate the clinical features of diabetic patients with bacterial liver abscess and different levels of glycosylated hemoglobin( Hb Alc). Methods A total of 118 adult diabetic patients with bacterial liver abscess who were admitted to our hospital from December 2014 to December 2018...

Case reports
Histological reversal after treatment of drug-induced cirrhosis with Yiqi Liangxue TCM combined with Fuzheng Huayu Capsule: A case report
Wang Yu, Lu: Jing, Liu ChengHai
2019, 35(11): 2542-2544. DOI: 10.3969/j.issn.1001-5256.2019.11.030
Abstract:
Suspected seventh-day syndrome after liver transplantation for liver cancer: A case report
Jia Fan, Li Ang, Chen Hong, Lu Qian
2019, 35(11): 2545-2546. DOI: 10.3969/j.issn.1001-5256.2019.11.031
Abstract:
Ganglioneuroma in the hepatic hilar region: A case report
Fan YeHui, Ji JingWei, Wang XiaoLei, Zhang ShiLiang, Zhang RuoYan, Qiu Wei, Wang GuangYi, Wu Hao
2019, 35(11): 2547-2548. DOI: 10.3969/j.issn.1001-5256.2019.11.032
Abstract:
Hepatolenticular degeneration with MTHFR gene mutation: A case report
Li Ning, Zhang Xin, Li Rui, Jiao Lin
2019, 35(11): 2549-2550. DOI: 10.3969/j.issn.1001-5256.2019.11.033
Abstract:
Biliary neuroendocrine carcinoma: A case report
Yi Dan, Wang ShuPeng, Dong ShanShan, Ren XueKang, Niu ChunYuan, Liu SongYang
2019, 35(11): 2551-2552. DOI: 10.3969/j.issn.1001-5256.2019.11.034
Abstract:
Ligamentum teres hepatis hemorrhage after laparoscopic cholecystectomy: A case report
Ji JingWei, Liu Zhi, Xing MingXuan, Qi Jun, Du XiaoHong, Wang GuangYi
2019, 35(11): 2553-2554. DOI: 10.3969/j.issn.1001-5256.2019.11.035
Abstract:
A case of spontaneous splenic artery aneurysm rupture
Liao TingHai, Yang Fan, Li GuoWei, Feng Yu, Yang DaGang, Yuan HongTao
2019, 35(11): 2555-2556. DOI: 10.3969/j.issn.1001-5256.2019.11.036
Abstract:
Reviews
Vertical transmission of hepatitis B virus: Modes and blocking strategies
Zhao Fei, Liu Fei, Wang ZhongFeng, Li HaiJun, Xu HongMei
2019, 35(11): 2557-2560. DOI: 10.3969/j.issn.1001-5256.2019.11.037
Abstract:
Mother-to-child vertical transmission is the main mode of transmission of chronic hepatitis B in China. The probability of failure in blocking vertical transmission is about 10% in pregnant mothers with a high viral load,and therefore,correct management of hepatitis B virus( HBV) is of great importa...
Association between hepatitis B virus infection and bile acid
Li Shuo, Li ZhiGuo, Ye YongAn
2019, 35(11): 2561-2564. DOI: 10.3969/j.issn.1001-5256.2019.11.038
Abstract:
Hepatitis B virus( HBV) infection is closely associated with bile acid. Recent studies have shown that HBV infection is involved in the regulation of bile acid metabolism through bile acid transporters and mediation of liver injury,and bile acid changes HBV biosynthesis through FXR. This article rev...
Role of intestinal flora-mediated immune response in chronic hepatitis B virus infection
Gao Hui, Liu ShouSheng, Zhao ZhenZhen, Xin YongNing
2019, 35(11): 2565-2568. DOI: 10.3969/j.issn.1001-5256.2019.11.039
Abstract:
Hepatitis B virus( HBV) infection can cause acute or chronic liver injury. Chronic hepatitis B( CHB)-related liver cirrhosis and hepatocellular carcinoma usually lead to an increase in mortality,and their pathogenesis may be associated with immune response. Intestinal flora plays an important role i...
Immunotherapy for chronic hepatitis B
Wu XiaoMin, Tong QiaoYun, Liu Wei
2019, 35(11): 2569-2572. DOI: 10.3969/j.issn.1001-5256.2019.11.040
Abstract:
Although current direct anti-hepatitis B virus( HBV) drugs have good effects in controlling viral replication and limiting the progression to liver cirrhosis,there is still a long way to go in the treatment of chronic hepatitis B( CHB). Immune tolerance and immune dysfunction may be the two most imp...
Research advances in targeted therapy for hepatocellular carcinoma
Huang Shen, Yang ChengLei, Zhang ZhiMing
2019, 35(11): 2573-2577. DOI: 10.3969/j.issn.1001-5256.2019.11.041
Abstract:
Hepatocellular carcinoma( HCC) is one of the most common malignant tumors. Due to the insidious onset,poor prognosis,and lack of specificity of HCC,most patients have reached the advanced stage at the time of diagnosis. Conventional treatment methods,such as surgical resection,liver transplantation,...
Research advances in the risk factors for microvascular invasion in hepatocellular carcinoma
Bai Xue, Ma ZuoHong, Hao ZhiQiang, Fu XiBo, Jiao Ao, Shang Hai, Hua XiangDong
2019, 35(11): 2578-2581. DOI: 10.3969/j.issn.1001-5256.2019.11.042
Abstract:
Liver cancer is one of the most common malignant tumors in the world,and at present,China has the highest incidence rate of liver cancer. Liver cancer has an insidious onset,and patients often have no obvious symptoms in the early stage; however,due to the rapid progression of this disease,most pati...
Research advances in traditional Chinese medicine regulation of autophagy in treatment of liver cancer
Gu Huan, Bai ZhangChuan, Liu Liu, Cheng QiuLuo, Zhu Ying
2019, 35(11): 2582-2587. DOI: 10.3969/j.issn.1001-5256.2019.11.043
Abstract:
Autophagy has become a research hotspot in the prevention and treatment of tumor in recent years. With the help of the bidirectional regulatory effect of autophagy,it can not only provide energy and a stable internal environment for normal and tumor cells by clearing misfolded proteins and damaged o...
Research advances in the pathogenesis of nonalcoholic fatty liver disease
Jiang YuZi, Nie HongMing, Wang Rong
2019, 35(11): 2588-2591. DOI: 10.3969/j.issn.1001-5256.2019.11.044
Abstract:
Nonalcoholic fatty liver disease( NAFLD) is the leading cause of chronic liver dysfunction and has complex pathogenesis and progression. With in-depth studies in recent years,the theory of“two hits”has gradually been replaced by the theory of“multiple hits”. The theory of“multiple hits”including the...
Advances in the clinical research on autoimmune liver disease with Sjgren's syndrome
Zhang Xia, Luo LiTing, Ma HeMing, Ren TianQi, Niu JunQi
2019, 35(11): 2592-2595. DOI: 10.3969/j.issn.1001-5256.2019.11.045
Abstract:
Autoimmune liver disease is a group of liver diseases caused by the disorder of the autoimmune system,and some patients may have the symptoms of dry mouth and dry eyes. Patients with autoimmune liver disease and Sjgren's syndrome are commonly seen in clinical practice. This article summarizes the r...
Research advances in the diagnosis and treatment of acute-on-chronic liver failure with infection
Lu AiQi, Yang KeLi, Guan YuJuan
2019, 35(11): 2596-2599. DOI: 10.3969/j.issn.1001-5256.2019.11.046
Abstract:
Acute-on-chronic liver failure( ACLF) is a severe syndrome of liver diseases commonly seen in clinical practice and can lead to severe disorders and decompensation of liver synthesis,metabolism,detoxification,and biotransformation,as well as multiple organ failure and an extremely high short-term mo...
Establishment and application value of a monosodium glutamate-rat-liver regeneration model
Li HanMin
2019, 35(11): 2600-2604. DOI: 10.3969/j.issn.1001-5256.2019.11.047
Abstract:
The establishment of an animal model of liver regeneration in a state of neuro-endocrine-immune network dysfunction is an urgent need to promote the research on the regulatory mechanism of liver regeneration. The monosodium glutamate( MSG)-rat-liver regeneration model is a composite model of liver r...
Differences in the clinicopathological features of pancreatic head carcinoma arising from the dorsal pancreas and the ventral pancreas
Wang DaSong, Ye Hui
2019, 35(11): 2605-2608. DOI: 10.3969/j.issn.1001-5256.2019.11.048
Abstract:
The pancreas arises from the dorsal and ventral anlagen. The dorsal anlagen forms the cephalic part of the head of the pancreas,the neck of the pancreas,the body of the pancreas,and the tail of the pancreas,while the ventral anlagen forms the caudal part of the head of the pancreas and the uncinate ...