2019 No. 4

2019 Vol. 35, No. 4

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Editorial

The era of the reversal of liver fibrosis and cirrhosis: Current status and challenges

Wang BingQiong, Sun YaMeng, You Hong

2019, 35(4): 705-708. DOI: 10.3969/j.issn.1001-5256.2019.04.001

Abstract(809)

PDF (206KB)(566) Cited By (23)

Abstract:
An increasing number of clinical studies have shown that effective etiological therapy might achieve the reversal of liver fibrosis/early cirrhosis. An accurate assessment of fibrosis reversal is of great importance for treatment decision-making and prognosis prediction. At present, the“gold standar...

Discussions by experts

Histological assessment of reversal of liver fibrosis and cirrhosis

Zheng YongJian, Wang Yan

2019, 35(4): 709-713. DOI: 10.3969/j.issn.1001-5256.2019.04.002

Abstract(2076)

PDF (2001KB)(493) Cited By (15)

Abstract:
Liver fibrogenesis is a common pathway of pathological progression of chronic liver injuries. The diagnosis of liver fibrosis provides an important basis for treatment decision-making and prognostic evaluation of chronic liver diseases. With the rapid development of therapeutics, many new clinical i...

Serological assessment of the reversal of liver fibrosis and cirrhosis

Liu TianHui

2019, 35(4): 714-719. DOI: 10.3969/j.issn.1001-5256.2019.04.003

Abstract(1673)

PDF (2009KB)(454) Cited By (15)

Abstract:
Liver fibrosis/cirrhosis is the common pathological process of most chronic liver diseases. Many studies have confirmed that a certain degree of the reversal of liver fibrosis or cirrhosis can be achieved after effective treatment. How to use simple serological markers to evaluate the reversal of li...

Radiological evaluation of the reversal of liver fibrosis and cirrhosis

Chen YongPeng, Liang XieEr

2019, 35(4): 720-723. DOI: 10.3969/j.issn.1001-5256.2019.04.004

Abstract(1686)

PDF (1987KB)(445) Cited By (12)

Abstract:
Noninvasive methods for the evaluation of liver fibrosis have been widely validated with liver biopsy as the gold standard. This article elaborates on the application of various imaging methods in the evaluation of liver fibrosis and their prospects in evaluating the reversal of liver fibrosis. Tran...

Clinical assessment of the reversal of liver cirrhosis: “Point of return”

Zhao WenShan, Xie Wen

2019, 35(4): 724-727. DOI: 10.3969/j.issn.1001-5256.2019.04.005

Abstract(1852)

PDF (1981KB)(502) Cited By (2)

Abstract:
Nowadays, many clinical studies have demonstrated that some patients can achieve the reversal of liver cirrhosis. Therefore, the methods for accurate assessment of whether the reversal of liver cirrhosis can be achieved and when it is achieved have become the hotspots in clinical research. This help...

Advances in the understanding and treatment of liver fibrosis in traditional Chinese medicine

Liu ChengHai, Zhao ZhiMin, Lyu Jing

2019, 35(4): 728-733. DOI: 10.3969/j.issn.1001-5256.2019.04.006

Abstract(2442)

PDF (2088KB)(605) Cited By (67)

Abstract:
Liver fibrosis is commonly seen in various chronic liver diseases. In history, traditional Chinese medicine ( TCM) clinical practice based on syndrome differentiation and treatment formed unique experience in the diagnosis and treatment of liver fibrosis; in recent years, studies based on experiment...

Academic contention

Effect of entecavir versus tenofovir disoproxil fumarate antiviral therapy in reducing the risk of hepatocellular carcinoma in patients with chronic hepatitis B: Reflections on a Korean retrospective study

Hong ShengZhen, Xu Jie

2019, 35(4): 734-736. DOI: 10.3969/j.issn.1001-5256.2019.04.007

Abstract(387)

PDF (171KB)(175) Cited By (9)

Abstract:
Recently, Choi et al. published a real-world study in JAMA Oncology, which showed that there was a significant difference between the entecavir group and the tenofovir disoproxil fumarate group in reducing the risk of hepatocellular carcinoma ( HCC) in chronic hepatitis B ( CHB) patients. This resul...

Therapeutic guidelines

Chinese expert consensus on multidisciplinary diagnosis and treatment of hepatocellular carcinoma with portal vein tumor thrombus ( 2018)

Chinese Society of Liver Cancer, Chinese Medical Doctor Association

2019, 35(4): 737-743. DOI: 10.3969/j.issn.1001-5256.2019.04.008

Abstract(668)

PDF (359KB)(772) Cited By (59)

Abstract:

Clinical practice guidelines for the interventional treatment of advanced pancreatic carcinoma (on trial) (3rd edition)

Committee of Interventional MedicineCancer Foundation of China;Committee of Interventional Medicine and BioengineeringChinese Society of Interventional Physicians;

2019, 35(4): 744-754. DOI: 10.3969/j.issn.1001-5256.2019.04.009

Abstract(849)

PDF (488KB)(507) Cited By (11)

Abstract:

An excerpt of AISF position paper on HCV in immunocompromised patients (2018)

Hao DaAng, Liu Ye, Shen ShanShan, Yan XueBing

2019, 35(4): 755-761. DOI: 10.3969/j.issn.1001-5256.2019.04.010

Abstract(294)

PDF (290KB)(91) Cited By (2)

Abstract:

An excerpt of management of hepatitis C virus infection in patients with chronic kidney disease: position statement of the joint committee of Italian association for the study of the liver (AISF), Italian society of internal medicine (SIMI), Italian society of infectious and tropical disease (SIMIT) and Italian society of nephrology (SIN)

Han Chao, Dou XiaoGuang

2019, 35(4): 762-765. DOI: 10.3969/j.issn.1001-5256.2019.04.011

Abstract(486)

PDF (203KB)(108) Cited By (6)

Abstract:

An excerpt of hepatocellular carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up (2018)

Lyu JiaYu, Han Tao

2019, 35(4): 766-768. DOI: 10.3969/j.issn.1001-5256.2019.04.012

Abstract(381)

PDF (172KB)(316) Cited By (4)

Abstract:

Original articles_Viral hepatitis

Clinical significance of the measurement of peripheral blood Epstein-Barr virus load in patients with HBV infection

Ran RuoXi, Xiao MengYao, Li AnLing, Liu SongMei

2019, 35(4): 769-773. DOI: 10.3969/j.issn.1001-5256.2019.04.013

Abstract(1808)

PDF (2092KB)(308) Cited By (8)

Abstract:

Objective To investigate the clinical significance of co-infection with hepatitis B virus ( HBV) and Epstein-Barr virus ( EBV) in HBV-related liver diseases such as chronic hepatitis B ( CHB) , liver cirrhosis, and hepatocellular carcinoma ( HCC) . Methods A retrospective analysis was performed for ...

Original articles_Liver fibrosis and liver cirrhosis

Expression of serum EBV-miR-BART13-3p and its diagnostic value in patients with chronic hepatitis B liver fibrosis in Qinghai, China

Li PingYing, Yang YongGeng, Li Juan, Shen YouXiu, Ma YingCai, Lu LunGen

2019, 35(4): 774-779. DOI: 10.3969/j.issn.1001-5256.2019.04.014

Abstract(1616)

PDF (2095KB)(292) Cited By (2)

Abstract:
Objective To investigate the difference in the expression of serum EBV-miR-BART13-3 p between chronic hepatitis B ( CHB) patients with different liver fibrosis stages in Qinghai, China and the value of serum EBV-miR-BART13-3 p in the diagnosis of CHB liver fibrosis. Methods A total of 100 patients w...

Clinical effect of Liqi Jianpi prescription in preventing hemorrhage within one year in patients with hepatitis B cirrhosis and severe esophageal and gastric varices

Hou YiXin, Yang ZhiYun, Yang YuYing, Jiang YuYong, Wang XianBo

2019, 35(4): 780-784. DOI: 10.3969/j.issn.1001-5256.2019.04.015

Abstract(1614)

PDF (1994KB)(311) Cited By (9)

Abstract:
Objective To investigate the effect of Liqi Jianpi prescription on the risk of hemorrhage within one year in patients with hepatitis B cirrhosis and severe esophageal and gastric varices. Methods The patients who were hospitalized in Beijing Ditan Hospital from January2010 to August 2017 and were di...

Features of intestinal microbiota in hepatitis B cirrhosis patients with amassment or tympanites type of liver-kidney Yin deficiency syndrome: A comparative analysis

Cai WenJun, Luan YuTing, Liu ChengHai, Jiang ShiLi, Zhao ZhangQing, Gu HongTu, Yuan JiLi, Xing Feng, Zhou Yang, Lu: Jing, Mu YongPing

2019, 35(4): 785-789. DOI: 10.3969/j.issn.1001-5256.2019.04.016

Abstract(1766)

PDF (2402KB)(320) Cited By (10)

Abstract:
Objective To investigate the distribution of intestinal microbiota in hepatitis B cirrhosis patients with amassment or tympanites type of liver-kidney Yin deficiency syndrome through a comparative analysis.Methods A total of 21 hepatitis B cirrhosis patients with amassment type of liver-kidney Yin d...

Value of neutrophil-lymphocyte ratio in predicting the prognosis of patients with decompensated cirrhosis

Liang LiMin, Xu HeXiang, Zheng JiShun, Zhang YuanYuan

2019, 35(4): 790-795. DOI: 10.3969/j.issn.1001-5256.2019.04.017

Abstract(1897)

PDF (2088KB)(344) Cited By (19)

Abstract:
Objective To investigate the value of neutrophil-lymphocyte ratio ( NLR) in predicting the prognosis of patients with decompensated cirrhosis. Methods A retrospective analysis was performed for the clinical data of 173 patients who were diagnosed with decompensated cirrhosis in The Third Affiliated ...

Correlation between serum CA125 level and severity of liver dysfunction in patients with liver cirrhosis: A Meta-analysis

Shao CuiPing, Xu YouQing

2019, 35(4): 796-800. DOI: 10.3969/j.issn.1001-5256.2019.04.018

Abstract(1722)

PDF (2064KB)(300) Cited By (2)

Abstract:
Objective To investigate the correlation between serum CA125 level and the severity of liver dysfunction in patients with liver cirrhosis. Methods Wanfang Data, CNKI, CBM, and VIP were searched for Chinese articles on the correlation between serum CA125 level and the severity of liver dysfunction in...

Effect of propranolol on hemodynamics and its clinical significance in patients with portal hypertension

Xu Hui, Zhang Feng, Zhang Ming, Zhu GeYuZheng

2019, 35(4): 801-807. DOI: 10.3969/j.issn.1001-5256.2019.04.019

Abstract(1870)

PDF (2131KB)(335) Cited By (8)

Abstract:
Objective To investigate whether short-term oral administration of propranolol can induce hemodynamic response in patients with liver cirrhosis and esophageal and gastric varices, as well as the clinical significance of such response in the prevention of esophagogastric variceal bleeding ( EGVB) . M...

Interventional effect of mangiferin on carbon tetrachloride-induced hepatic fibrosis in mice

Wang Hu, Cheng Yujia, Wang Li, Liao Yifeng, Cao Jiang

2019, 35(4): 808-812. DOI: 10.3969/j.issn.1001-5256.2019.04.020

Abstract(603)

PDF (2571KB)(28)

Abstract:

ObjectiveTo investigate the interventional effect of mangiferin on carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice and the potential mechanism. MethodsA total of 45 male C57BL/6 mice were randomly divided into three groups: normal control group (NC group), liver fibrosis model group (CC...

Original articles_Liver neoplasms

Clinical effect of ablation in treatment of needle tract implantation after radiofrequency ablation for primary liver cancer

Lu NingNing, Wang HaiYan, Zhang YingHua, Sun Bin, Zhang YongHong, Cui XiongWei, Zheng JiaSheng

2019, 35(4): 813-817. DOI: 10.3969/j.issn.1001-5256.2019.04.021

Abstract(2180)

PDF (2220KB)(313) Cited By (19)

Abstract:
Objective To investigate the risk factors for needle tract implantation after radiofrequency ablation for primary liver cancer and the clinical effect of ablation. Methods A retrospective analysis was performed for the clinical data of 4 patients with needle tract implantation after radiofrequency a...

Clinical effect of transcatheter arterial chemoembolization combined with radiofrequency ablation in treatment of Barcelona Clinical Liver Cancer stage B primary liver cancer and influencing factors for prognosis

Sun Yu, Zhang HongHai, Sheng ShouPeng, Li Cong, Yuan ChunWang, Cui ShiChang, Hu CaiXia, Liu BoJun, Li XingMing, Zhang YongHong, Zheng JiaSheng

2019, 35(4): 818-824. DOI: 10.3969/j.issn.1001-5256.2019.04.022

Abstract(1897)

PDF (2502KB)(289) Cited By (33)

Abstract:
Objective To investigate the clinical effect of transcatheter arterial chemoembolization ( TACE) combined with radiofrequency ablation ( RFA) in the treatment of Barcelona Clinical Liver Cancer ( BCLC) stage B primary liver cancer and influencing factors for prognosis. Methods A total of 154 patient...

Determination and clinical significance of plasma matrix metalloproteinase in patients with hepatocellular carcinoma

Zhang HongHai, Sun Yu, Liu Fang, Xie Li, Qiao LuXin, Chen DeXi, Yin JiMing

2019, 35(4): 825-829. DOI: 10.3969/j.issn.1001-5256.2019.04.023

Abstract(1472)

PDF (2001KB)(298) Cited By (8)

Abstract:
Objective To investigate the expression of matrix metalloproteinases ( MMPs) in patients with hepatocellular carcinoma ( HCC) and its association with clinicopathological features. Methods A total of 131 patients who were hospitalized and treated in Beijing YouAn hospital from October 2015 to May 20...

Original articles_Pancreatic diseases

Clinical features of severe acute hypertriglyceridemic pancreatitis

Tang YongFeng, Tang GuoDou, Liang ZhiHai, Tan MengBin, Huang HuaLi, Tan MinZhen

2019, 35(4): 830-834. DOI: 10.3969/j.issn.1001-5256.2019.04.024

Abstract(1243)

PDF (2088KB)(318) Cited By (33)

Abstract:
Objective To investigate the clinical features of severe acute hypertriglyceridemic pancreatitis ( HTGP) . Methods A retrospective analysis was performed for the clinical data of 179 patients with moderate severe pancreatitis ( MSAP) or severe acute pancreatitis ( SAP) who were admitted to The First...

Original articles_Others

Risk factors for the coexistence of inflammatory bowel disease and nonalcoholic fatty liver disease: A Meta-analysis

Feng Gong, He Na, Mi Man, Li XuePing, Liu ManLing, Fan LiPing, Niu ChunYan

2019, 35(4): 835-839. DOI: 10.3969/j.issn.1001-5256.2019.04.025

Abstract(1456)

PDF (2509KB)(299) Cited By (1)

Abstract:

Objective To investigate whether glucocorticoids, anti-tumor necrosis factor ( anti-TNF) drugs, and a past history of surgical treatment of inflammatory bowel disease ( IBD) are the risk factors for the coexistence of IBD and nonalcoholic fatty liver disease ( NAFLD) . Methods PubMed, Embase, Cochra...

Influence of low-level lead exposure on liver function and blood lipids in rats with nonalcoholic fatty liver disease

Zhu WeiMei, Wang XiuFang, Yang HaiQing, Yang HongLing, Li XueZhang, Pan Yue

2019, 35(4): 840-845. DOI: 10.3969/j.issn.1001-5256.2019.04.026

Abstract(1519)

PDF (2178KB)(317) Cited By (5)

Abstract:

Objective To investigate the influence of low-lead high-fat diet on liver function and blood lipids in rats with nonalcoholic fatty liver disease ( NAFLD) , as well as the expression of sterol regulatory element-binding protein-1 c ( SREBP-1 c) , fatty acid synthase ( FAS) , and acetyl-CoA carboxyla...

Mild hypothermia exerts a protective effect against hepatic ischemia-reperfusion injury in rats by activating the PI3K/Akt signaling pathway

Liu Jian, Li Li, Wang XiaoChuan, Zhang ShengNing, Li LaiBang, Mang YuanYi, Gao Yang, Chen YongLin, Ren Gang, Li Wang

2019, 35(4): 846-851. DOI: 10.3969/j.issn.1001-5256.2019.04.027

Abstract(1402)

PDF (2378KB)(284) Cited By (7)

Abstract:

Objective To investigate the protective mechanism of mild hypothermia pretreatment against hepatic ischemia-reperfusion injury in rats. Methods A total of 40 male Sprague-Dawley rats were randomly divided into sham-operation group ( Sham group) , hepatic ischemia-reperfusion injury group ( HIRI grou...

Case reports

HBV reactivation in patients with IgG4-related sclerosing cholangitis after liver transplantation: A case report

Fang YiNa, Dong KaiHui, Chen QingLing, Wei QianQian, Yu ChengNan, Kui YiWen, Mao MiaoMiao, Wen XiaoYu, Jin QingLong

2019, 35(4): 852-853. DOI: 10.3969/j.issn.1001-5256.2019.04.028

Abstract(1122)

PDF (1965KB)(256)

Abstract:

A case of jaundice of unknown origin

Gao LuHua, Nie QingHe, Zhao XiTai

2019, 35(4): 854-857. DOI: 10.3969/j.issn.1001-5256.2019.04.029

Abstract(1119)

PDF (2284KB)(292)

Abstract:

Small-for-size syndrome in hepatic alveolar echinococcosis treated by ex vivo liver resection and autotransplantation: A case report

Ye HaiWen, Zhou Ying, Lu Qian, Zhang LingQiang, Deng Yong, Xu XiaoLei, Li XiaoWen, Jia Fan, Wang HaiJiu, Fan HaiNing

2019, 35(4): 858-860. DOI: 10.3969/j.issn.1001-5256.2019.04.030

Abstract(1194)

PDF (2496KB)(264) Cited By (3)

Abstract:

A case of eosinophilia secondary to infection with Clonorchis sinensis and Ascaris lumbricoides

Wang HaiXia, Cai YanJun, Li WanYu, Mei QiTeng, Qi Yue

2019, 35(4): 861-862. DOI: 10.3969/j.issn.1001-5256.2019.04.031

Abstract(1365)

PDF (2008KB)(316) Cited By (5)

Abstract:

Collision carcinoma of the common bile duct composed of neuroendocrine small cell carcinoma and high-grade adenocarcinoma： A case report

Liu Zhao, Zhang YaMeng, Wang BaoSheng

2019, 35(4): 863-865. DOI: 10.3969/j.issn.1001-5256.2019.04.032

Abstract(1251)

PDF (2250KB)(247) Cited By (1)

Abstract:

A case of primary liposarcoma of the pancreas

Zhang JianWei, Ji JingWei, Xing MingXuan, Wang GuangYi, Du XiaoHong

2019, 35(4): 866-867. DOI: 10.3969/j.issn.1001-5256.2019.04.033

Abstract(1397)

PDF (2038KB)(273)

Abstract:

VHL syndrome with multiple pancreatic cysts and fourth ventricle hemangioblastoma: A case report

Zhuang ChunYu, Chen XiaoJing, Chen JiaCheng, Zhou KaiLun

2019, 35(4): 868-869. DOI: 10.3969/j.issn.1001-5256.2019.04.034

Abstract(1339)

PDF (2223KB)(251)

Abstract:

A case of adenosquamous carcinoma of the ampulla of Vater

Abudureyimu Tuerhong, Wang Kun, Liu Kai, Liu YaHui

2019, 35(4): 870-871. DOI: 10.3969/j.issn.1001-5256.2019.04.035

Abstract(1264)

PDF (2168KB)(257)

Abstract:

Infectious mononucleosis with polyserous effusions: A case report

Ji TongTong, Zhu WenYan, Lu HaiYing, Yu YanYan

2019, 35(4): 872-873. DOI: 10.3969/j.issn.1001-5256.2019.04.036

Abstract(1411)

PDF (2016KB)(260) Cited By (2)

Abstract:

Reviews

Association between chronic hepatitis B and nonalcoholic fatty liver disease and pathogenesis of chronic hepatitis B with nonalcoholic fatty liver disease

Huang BeiBei, Li Lei

2019, 35(4): 874-878. DOI: 10.3969/j.issn.1001-5256.2019.04.037

Abstract(1571)

PDF (2010KB)(329) Cited By (10)

Abstract:
At present, hepatitis B virus ( HBV) infection is one of the leading causes of liver cirrhosis and liver cancer. With the development of the society, the improvement in living standards, and the change in lifestyle, nonalcoholic fatty liver disease ( NAFLD) has gradually replaced hepatitis B and bec...

Association between HBeAg-negative chronic hepatitis B and pre C/BCP mutation

Dai HaiMei, Wei Jia

2019, 35(4): 879-882. DOI: 10.3969/j.issn.1001-5256.2019.04.038

Abstract(1635)

PDF (1999KB)(330) Cited By (9)

Abstract:
Studies on the HBV gene have shown that HBeAg-negative chronic hepatitis B ( CHB) is associated with gene mutations in the pre-C ( preC) and basic core promoter ( BCP) region of HBV DNA, and it is pointed out that the mutation in the preC/BCP region can affect the expression of serum HBeAg and is cl...

Research advances in Th1/Th2 balance and fibrotic diseases

Huang Hui, Zhou Yang, Ping Jian, Xu LieMing

2019, 35(4): 883-886. DOI: 10.3969/j.issn.1001-5256.2019.04.039

Abstract(1546)

PDF (1988KB)(295) Cited By (20)

Abstract:
Body immunity is closely associated with the pathogenesis of fibrotic diseases. In CD4+ T lymphocyte subsets, T helper 1 ( Th1) /T helper 2 ( Th2) balance plays an important regulatory role in the development and progression of many diseases. This article describes the association of Th1/Th2 balance...

Influence of intestinal dysbacteriosis on liver cirrhosis

Li YunPeng, Wang XinHong, Zhang DeKai

2019, 35(4): 887-890. DOI: 10.3969/j.issn.1001-5256.2019.04.040

Abstract(1492)

PDF (1980KB)(288) Cited By (14)

Abstract:
Liver cirrhosis is a progressive chronic liver disease due to one or more causes, with diffuse fibrosis in liver tissue, pseudolobules, and regenerative nodules as major histological features. Once liver cirrhosis enters the decompensated stage, the liver and several other organs are injured, which ...

Assessment and clinical management of sarcopenia in patients with liver cirrhosis

Han Fang, Han Tao, Liang Jing

2019, 35(4): 891-894. DOI: 10.3969/j.issn.1001-5256.2019.04.041

Abstract(1456)

PDF (1992KB)(352) Cited By (10)

Abstract:
As the disease progresses, there is a significant change in the body composition of patients with liver cirrhosis, and sarcopenia is one of the common complications in liver cirrhosis, especially in decompensated cirrhosis. About 30%-70% of patients with liver cirrhosis have sarcopenia, which greatl...

Application and management of autologous bone marrow stem cells in treatment of liver cirrhosis

Wang Deng, Sun Hang, Wu ChuanXin

2019, 35(4): 895-898. DOI: 10.3969/j.issn.1001-5256.2019.04.042

Abstract(1913)

PDF (1994KB)(390) Cited By (3)

Abstract:
Liver transplantation is considered the best method for the treatment of liver cirrhosis, but its clinical application is limited by the shortage of liver donors, high costs, and immunological rejection. In recent years, bone marrow stem cells ( BMSCs) has shown great prospects in the treatment of l...

Current status and perspectives of the treatment of hepatocellular carcinoma with portal vein tumor thrombus

Zhang XueWen, Dai ChaoLiu

2019, 35(4): 899-904. DOI: 10.3969/j.issn.1001-5256.2019.04.043

Abstract(1672)

PDF (2044KB)(456) Cited By (13)

Abstract:
Portal vein tumor thrombus is one of the most common complications of advanced hepatocellular carcinoma and greatly affects the treatment and prognosis of such patients. With the development and advances in surgical treatment methods, local interventional treatment, radiation therapy, targeted drug ...

Features and clinical significance of nutritional metabolism in patients with primary liver cancer

Zhao WenHao, Liu XueLian, Li HongWei, Wang Xu, Liu XiangLiang, Li Wei

2019, 35(4): 905-907. DOI: 10.3969/j.issn.1001-5256.2019.04.044

Abstract(1235)

PDF (1974KB)(288) Cited By (27)

Abstract:
Nutritional metabolism is closely associated with the treatment of tumors and is an important research field in China and foreign countries. On the one hand, the use of nutrient metabolism pathway molecules as therapeutic targets has become a new direction in the field of biomedical research; on the...

Current status of the research and development of new formulations and drugs for cystic echinococcosis

Yin Jie, Fan HaiNing, Wen Hao, Wang HaiJiu, Zhang LingQiang, Pang MingQuan, Gu XianBo, Wang Tao, Pan SiYu

2019, 35(4): 908-912. DOI: 10.3969/j.issn.1001-5256.2019.04.045

Abstract(1151)

PDF (2001KB)(280) Cited By (10)

Abstract:
Cystic echinococcosis ( CE) is a zoonotic parasitic disease caused by Echinococcus granulosus infection and can involve the organs in the whole body. Surgery is the primary method for the treatment of CE. With the development of related techniques, precision operation, and no-tumor operation standar...

Liver microcirculation disturbance in nonalcoholic fatty liver disease

Liu YaJuan, Li LiangPing

2019, 35(4): 913-916. DOI: 10.3969/j.issn.1001-5256.2019.04.046

Abstract(1171)

PDF (1985KB)(302) Cited By (7)

Abstract:
At present, the pathogenesis of nonalcoholic fatty liver disease ( NAFLD) is not completely clear, but hepatic microcirculation perfusion is an important feature of disease progression, in which lipid accumulation in hepatocytes is the key to microvascular injury. This article introduces the functio...

Advances in the treatment of nonalcoholic fatty liver disease in children

Li ZeSheng, Wu Jie

2019, 35(4): 917-920. DOI: 10.3969/j.issn.1001-5256.2019.04.047

Abstract(1264)

PDF (1994KB)(362) Cited By (2)

Abstract:
Nonalcoholic fatty liver disease ( NAFLD) refers to a syndrome of a series of lesions such as simple fatty liver disease, nonalcoholic steatohepatitis, liver fibrosis, and even liver cirrhosis. With the improvement of living standards, there is an increasing number of children with obesity, and the ...

Diagnosis and treatment of inherited metabolic liver disease

Zhang YaNan, Xu Ying, Jiang Chang, Gao YanHang

2019, 35(4): 921-924. DOI: 10.3969/j.issn.1001-5256.2019.04.048

Abstract(2099)

PDF (1987KB)(582) Cited By (12)

Abstract:
The liver is the key place for most metabolic pathways, so it is often involved earliest and has the most severe injury, and liver injury of some inherited metabolic diseases may develop into liver cirrhosis and even malignant tumors of the liver and tended to have poor prognosis. Inherited metaboli...

Recent advances in drug-induced liver injury: Potential mechanisms, pathological features, and biomarkers

Geng WenJing, Liu Hui, Ding HuiGuo

2019, 35(4): 925-929. DOI: 10.3969/j.issn.1001-5256.2019.04.049

Abstract(1571)

PDF (2005KB)(346) Cited By (30)

Abstract:
Drug-induced liver injury ( DILI) is one of the main causes of acute liver failure, black box warnings, and drug withdrawal from the market, and it is also a major concern in public health, drug research and development, and the pharmaceutical industry. However, a lack of specific diagnostic markers...

Association between nuclear factor-erythroid 2-related factor-2 antioxidant pathway and liver diseases

He GuoNa, Shen FengJun

2019, 35(4): 930-933. DOI: 10.3969/j.issn.1001-5256.2019.04.050

Abstract(2360)

PDF (1991KB)(266) Cited By (3)

Abstract:
Nuclear factor-erythroid 2-related factor-2 ( Nrf2) is an important transcription factor for cells to resist oxidative stress. It interacts with antioxidant response elements to induce the expression of downstream protective phase II detoxification enzymes and antioxidant enzymes and thus exerts a p...

Current status of research on bile duct lesions and related liver diseases

Xu JiaMin, Tang YingMei

2019, 35(4): 934-936. DOI: 10.3969/j.issn.1001-5256.2019.04.051

Abstract(1187)

PDF (1981KB)(307) Cited By (4)

Abstract:
The bile duct is the channel for bile transport in the liver, and the lining epithelial cells in the bile duct have functional and morphological heterogeneity and are the target of various bile duct diseases. In addition to bile metabolism and secretion, biliary epithelial cells are also involved in...