Hepatobiliary and pancreatic diseases are common and frequently occurring diseases in the digestive system,and several hepatobiliary and pancreatic diseases are difficult to diagnose and treat,with a high incidence rate of complications. With the development of minimally invasive devices and instrum...

Acute pancreatitis( AP) is one of the common digestive diseases. With the advances in technology,the treatment concept of AP has changed,more and more minimally invasive techniques have been applied in the treatment of AP,especially severe acute pancreatitis( SAP). Although there are various differe...

Among digestive malignancies,compared with gastrointestinal tumors,biliary and pancreatic tumors are difficult to diagnose in the early stage and have fewer opportunities for radical surgical resection,with a shorter survival time and poorer quality of life,and the clinical diagnosis and treatment o...

Pancreaticoduodenectomy is one of the most difficult abdominal operations,and the difficulty in resection and complicated digestive tract reconstruction have brought great challenges for surgeons. At present,laparoscopic pancreaticoduodenectomy has been widely used in clinical practice,and compared ...

Since its official application in clinical practice in 2000,da Vinci robotic technology has developed rapidly in recent ten years,especially in the last two years,during which this technology has been widely promoted and used in China. However,in hepatopancreatobiliary( HPB) surgery,da Vinci robotic...

Laparoscopic hepatectomy has the advantages of little trauma,mild stress response,and rapid postoperative recovery. Due to the deep location and complex structure,tumors located in the upper right posterior areas of the liver( Ⅶ,Ⅷ,and Ⅳa segments) and the caudate lobe have limited surgical field and...

Pancreatic cancer( PC) remains one of the most challenging malignant tumor in gastrointestinal cancer,and the incidence and mortality rates are significantly increased in the past decades. The 5-years survival rate of PC is less than 8% since its dormant clinical symptoms and lacking of sensibility ...

Objective To investigate the pharmacokinetic characteristics of sofosbuvir tablets,and to evaluate the bioequivalence and safety of two preparations. Methods Healthy volunteers were recruited through the platform of clinical trial recruitment in The Affiliated Hospital of Changchun University of Chi...

Objective To investigate the bioequivalence and safety of the generic drug entecavir versus the original drug entecavir tablets in healthy Chinese subjects. Methods A randomized,open,two-cycle,two-cross,fasting trial was designed and performed for 28 healthy subjects,and the subjects were given sing...

Objective To investigate the efficacy and safety of elbasvir/grazoprevir in patients with genotype 1 hepatitis C in the real world.Methods A total of 35 patients with hepatitis C who received elbasvir/grazoprevir treatment in Guangzhou Eighth People's Hospital,Guangdong Provincial Hospital of Tradit...

Objective To investigate the changes of T helper 9( Th9) cells,interleukin-9( IL-9),and related transcription factors in previously untreated patients with chronic hepatitis C,as well as their association with clinical indices. Methods A total of 29 previously untreated patients with chronic hepatit...

Objective To investigate the value of peripheral blood long non-coding RNA-LET( lncRNA-LET) in the diagnosis of chronic hepatitis B( CHB) cirrhosis,and to provide a basis for early clinical diagnosis and treatment of liver cirrhosis. Methods A total of 175 CHB patients who attended The Affiliated Ho...

Objective To investigate the effect of direct-acting antiviral( DAA) on the recurrence of hepatitis C virus( HCV)-related hepatocellular carcinoma( HCC) after curative treatment. Methods PubMed,Web of Science,Cochrane Library,CNKI,CBM,Wanfang Data,and VIP were searched for the clinical studies of DA...

Objective To investigate the clinical effect and safety of transcatheter arterial chemoembolization( TACE) combined with microwave ablation( MWA) in the treatment of advanced primary liver cancer. Methods A total of 186 patients with advanced primary liver cancer who were treated in The Fifth Medica...

Objective To investigate the effect of kaempferol on the proliferation,migration,invasion,and apoptosis of human hepatoma Bel-7402 cells and related molecular mechanism. Methods Hepatoma Bel-7402 cells cultured in vitro were randomly divided into control group and low-,middle-,and high-concentration...

Objective To investigate the effect of arsenic trioxide-loaded CalliSpheres beads( CBATO) in transarterial chemoembolization( TACE) in the treatment of rabbits with VX2 liver tumor. Methods A total of 120 tumor-bearing rabbits were divided into control group,CalliSpheres beads( CB) group( blank bead...

Objective To investigate the etiology of liver diseases with negative hepatotropic virus,and to provide ideas for the clinical diagnosis and treatment of liver diseases. Methods A retrospective analysis was performed for the clinical data and liver biopsy results of 113 patients with negative hepato...

Objective To investigate the expression and clinical significance of OX40/OX40 L( CD134/CD134 L) in CD4 + T cells,CD8 +T cells,monocytes,and B lymphocytes in peripheral blood of patients with autoimmune hepatitis( AIH),primary biliary cholangitis( PBC),and their overlap syndrome before and after sta...

Objective To investigate the pathology,clinical features,population features,and etiology of non-viral hepatitis-related abnormal liver function in the elderly. Methods A retrospective analysis was performed for 50 elderly patients,with abnormal liver function as disease onset for the first time,who...

Objective To investigate the clinical features and causes of death after transjugular intrahepatic portosystemic shunt( TIPS) in patients with hepatic sinus obstruction syndrome( HSOS),as well as the prevention and treatment measures to further improve the survival rate of such patients. Methods A r...

Objective To investigate the etiology and clinical manifestations of liver failure in pregnancy and the value of TPL predictive model based on total bilirubin( TBil),prothrombin activity( PTA),and lactic acid( LACT) in evaluating the prognosis of liver failure in pregnancy. Methods A total number of...

Objective To investigate the correlation between body fat parameters and the severity of acute pancreatitis( AP) and the value of body fat parameters in predicting the severity of AP. Methods A retrospective analysis was performed for the clinical data of 229 patients with AP who were treated in Dep...

Objective To investigate the value of hyponatremia in predicting the severity of acute pancreatitis( AP). Methods Clinical data were collected from 459 AP patients who attended The Affiliated Hospital of Southwest Medical University from January to December2019,and according to the serum Na+level at...

Objective To investigate the risk factors for new-onset diabetes after incipient acute pancreatitis( AP). Methods A retrospective analysis was performed for 95 patients with post-acute pancreatitis diabetes mellitus( PPDM-A) after incipient AP who were admitted to The Affiliated Hospital of Southwes...

Objective To investigate the value of early fluid resuscitation endpoints in evaluating blood volume in patients with acute pancreatitis. Methods A retrospective analysis was performed for the clinical data of 445 previously untreated patients with acute pancreatitis who were admitted to The First A...

Objective To investigate the therapeutic effect of magnolol on severe acute pancreatitis( SAP) with acute lung injury from the aspect of the functional block of intestinal lymphatic circulation by magnolol. Methods A total of 30 healthy male Sprague-Dawley rats were randomly divided into sham-operat...

Objective To investigate the association of metabolic syndrome( MS) and its components with the overall survival of pancreatic cancer( PC) patients who do not receive antitumor therapy. Methods A retrospective analysis was performed for the data of patients who were diagnosed with PC in The Affiliat...

T helper 17( Th17) cells,differentiated from nave CD4 + T cells,can secrete a series of cytokines including interleukin-17,interleukin-21,and interleukin-22 and are meanwhile regulated by a variety of cytokines and genes,playing an important role in various inflammatory diseases. Th17 cells are wid...

A large number of studies in recent years have shown that long non-coding RNAs( lncRNAs) play an important regulatory role in the progression of liver fibrosis. This article briefly describes the definition,classification,and biological functions of lncRNAs and summarizes recent reports on the regul...

Esophagogastric variceal bleeding is one of the main causes of death in patients with liver cirrhosis,and therefore,early monitoring of esophageal and gastric varices may help to improve the prognosis of patients; however at present,hepatic venous pressure gradient and upper gastrointestinal endosco...

Minimal hepatic encephalopathy( MHE) refers to a state of neuropsychological or neurophysiological abnormality and normal cognitive function in patients with liver cirrhosis,which is commonly seen in patients with liver cirrhosis. Early diagnosis and treatment of MHE can improve the quality of life ...

Alcoholic liver disease( ALD) is a common cause of liver dysfunction and death due to liver-related diseases,which brings great harm to human health and social development. Many factors are involved in the development and progression of ALD,such as oxidative stress,change in gut microbiota,genetic v...

The incidence rate of nonalcoholic steatohepatitis is gradually increasing year by year,which calls for an urgent need for effective therapeutic drugs. In recent years,various drugs have been developed,including anti-oxidative stress drugs,insulin sensitizers,PPAR agonists,thyroid receptor agonists,...

Nonalcoholic fatty liver disease is a group of diseases with unclear pathophysiological mechanism and is closely associated with metabolic syndrome. Bacterial components and metabolites produced by gut microbiota can regulate glucose and lipid metabolism,inflammatory response,and oxidative stress,an...

Hepatocellular carcinoma has a low early diagnostic rate,and there is a lack of highly sensitive and specific tumor markers. In recent years,fluid biopsy technique,represented by circulating free DNA( cfDNA),has become an auxiliary method for the diagnosis of cancer and has attracted more and more a...

There are complex mechanisms in the development and progression of hepatocellular carcinoma,which have not been fully clarified at present. Zinc finger protein family is the largest transcription factor family in human genome,and more and more evidence has shown that zinc finger proteins play an imp...

Hepatic sclerosing hemangioma( HSH) is a rare benign tumor that is considered fibrosis and hyaline change caused by degenerative changes of cavernous angioma,and changes in pathological features cause the changes in imaging features,making this atypical hemangioma easily misdiagnosed as primary or m...

As a novel form of programmed cell death different from cell necrosis,apoptosis,and autophagy discovered in recent years,pyroptosis is characterized by cell membrane rupture and release of cell contents and proinflammatory factors mediated by gasdermin,thus leading to cell death. Pyroptosis signalin...

In recent years,more and more studies have shown that myeloid-derived suppressor cells( MDSCs) participate in the development and progression of various chronic liver diseases including chronic viral hepatitis,alcoholic liver disease,nonalcoholic fatty liver disease,autoimmune liver diseases,and liv...

Cholangiocarcinoma is a malignant tumor originating from the epithelium of bile ducts,and although it has a low incidence rate,most patients are in the end stage at the time of diagnosis since there are no prominent clinical manifestations at disease onset. Since there are problems such as insuffici...

The incidence rate of hypertriglyceridemic pancreatitis( HTGP) is gradually increasing,and its complex pathogenesis has not been fully elucidated,which causes the difficulty in treatment. At present,there are no recommended guidelines for the treatment of HTGP.According to the process of the develop...

A large amount of information,such as clinical hematological data and imaging images,can be extracted by artificial intelligence to form various quantifiable features,analyze the association between different features and problems concerned( such as diagnosis),and thus solve complex medical problems...