Logistic regression analysis of prognostic risk factors for hepatic encephalopathy

Objective To analyze the prognostic risk factors for hepatic encephalopathy( HE),and to explore the risk factors for prognosis.Methods A total of 385 patients with HE who were treated in Liaocheng People's Hospital from January 2006 to June 2014 were enrolled in this study and analyzed retrospectively. These patients were divided into improved group( n = 125) and deteriorated group( n = 260). A total of 25 clinical indices were selected,and non- conditional binary logistic regression analysis was performed for related data with SPSS.Results Univariate analysis showed that HE stage,upper gastrointestinal hemorrhage,hepatorenal syndrome( HRS),total bilirubin( TBil),and international normalized ratio( INR) were risk factors affecting the prognosis of HE( P = 0. 000,0. 009,0. 047,0. 002,and0. 027,respectively). Multivariate logistic regression analysis was further performed for the variables with statistical significance and the results showed that HE stage,upper gastrointestinal hemorrhage,HRS,TBil,and INR were independent risk factors affecting the prognosis of HE( P = 0. 000,0. 009,0. 000,0. 000,and 0. 008,respectively; OR( 95% CI) = 4. 388( 2. 997- 6. 424),2. 805( 1. 300- 6. 050),4. 036( 2. 018- 8. 072),1. 005( 1. 003- 1. 007),and 1. 446( 1. 099- 1. 901),respectively). Conclusion HE stage,upper gastrointestinal hemorrhage,HRS,TBil,and INR are risk factors affecting the prognosis of HE,and advanced HE stages,a high level of bilirubin,high INR,and presence of upper gastrointestinal hemorrhage and HRS indicate poor prognosis. The patient's HE stage,upper gastrointestinal hemorrhage,HRS,TBil,and INR are applied as the indices for prognosis of HE,and the equation based on the these indices may have a reference value in clinical practice.