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Feb.  2016
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Article Navigation >  Journal of Clinical Hepatology  > 2016  >  32(2): 337-341

Expression and roles of poly(ADP-ribose) polymerase-1 and caspase-3 in pancreatic cancer and adjacent tissues

DOI: 10.3969/j.issn.1001-5256.2016.02.029

  • Third Department of General Surgery,The Second People's Hospital of Lanzhou

  • Received Date: 2015-06-04
  • Published Date: 2016-02-20
    Abstract
  • Objective To investigate the protein expression of poly( ADP- ribose) polymerase- 1( PARP- 1) and caspase- 3 in pancreatic cancer and adjacent tissues. Methods A total of 66 cancer tissue samples and 113 samples of adjacent tissues were collected from the patients who underwent surgical treatment with a confirmed diagnosis of pancreatic cancer by postoperative pathological examinations in The First Hospital of Lanzhou University from January 2013 to June 2014,and immunohistochemical examinations were performed to measure the expression of PARP- 1 and caspase- 3 in these samples. The chi- square test was applied for comparison of categorical data between groups. Results Of all the 66 samples of pancreatic cancer,53 had varying degrees of PARP- 1 expression,with a positive rate of80. 3%; of all the 133 samples of adjacent tissues,39 had PARP- 1 expression,with a positive rate of 34. 5%; the expression of PARP-1 in the samples of pancreatic cancer was significantly higher than that in the samples of adjacent tissues( χ2= 34. 79,P < 0. 01). The expression of PARP- 1 in moderately and poorly differentiated samples of pancreatic cancer( 18 /25,72%; 10 /14,71. 4%) was significantly higher than that in highly differentiated samples( 3 /14,21. 4%)( χ2= 10. 76,P < 0. 01). Of all the 66 samples of pancreatic cancer,47 had varying degrees of caspase- 3 expression,with a positive rate of 71. 2%; of all the 133 samples of adjacent tissues,71 had caspase-3 expression,with a positive rate of 62. 8%. The expression of caspase- 3 in highly differentiated samples of pancreatic cancer( 11 /18,61. 1%) was significantly higher than that in moderately and poorly differentiated samples( 4 /20,20%; 0 /9,0)( χ2= 11. 44,P < 0. 01).Conclusion The expression level of PARP- 1 in the samples of pancreatic cancer is significantly higher than that in the samples of adjacent tissues,and the strong positive rate of PARP- 1 increases with the decrease in the degree of differentiation; the expression of caspase- 3 is similar between pancreatic cancer and adjacent tissues,and the strong positive rate of caspase- 3 decreases with the decrease in the degree of differentiation. The expression levels of PARP- 1 and caspase- 3 may be related to the development and progression of pancreatic cancer.

     

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