[1]FARES N,PERON JM.Epidemiology,natural history,and risk factors of hepatocellular carcinoma[J].Rev Prat,2013,63(2):216-217,220-222.
|
[2]KEW MC.Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma[J].J Gastroenterol Hepatol,2011,26(Suppl 1):144-152.
|
[3]MOTAVAF M,SAFARI S,SAFFARI JM,et al.Hepatitis B virus-induced hepatocellular carcinoma:the role of the virus x protein[J].Acta Virol,2013,57(4):389-396.
|
[4]DONG Y,WANG A.Aberrant DNA methylation in hepatocellular carcinoma tumor suppression(Review)[J].Oncol Lett,2014,8(3):963-968.
|
[5]LEE H,SOHN JB,KIM SS,et al.DNA methyltransferase inhibitor assay system based on the HBx-induced DNA methylation of Ecadherin[J].Biochem Biophys Res Commun,2013,438(3):540-545.
|
[6]KOTAKE Y,NAEMURA M,MURASAKI C,et al.Transcriptional regulation of the p16 tumor suppressor gene[J].Anticancer Res,2015,35(8):4397-4401.
|
[7]FERNANDEZ AF,ESTELLER M.Viral epigenomes in human tumorigenesis[J].Oncogene,2010,29(10):1405-1420.
|
[8]RONGRUI L,NA H,ZONGFANG L,et al.Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis[J].Curr Pharm Des,2014,20(11):1715-1725.
|
[9]KAUR P,PALIWAL A,DURANTEL D,et al.DNA methylation of hepatitis B virus(HBV)genome associated with the development of hepatocellular carcinoma and occult HBV infection[J].J Infect Dis,2010,202(5):700-704.
|
[10]CSEPREGI A,EBERT M,RCKEN C,et al.Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma[J].BMC Cancer,2010,10(1):317.
|
[11]ANZOLA M,CUEVAS N,LOPEZ MARTINEZ M,et al.p16INK4A gene alterations are not a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy[J].J Gastroenterol Hepatol,2004,19(4):397-405.
|
[12]MATSUDA Y,ICHIDA T,MATSUZAWA J,et al.p16(INK4)is inactivated by extensive Cp G methylation in human hepatocellular carcinoma[J].Gastroenterology,1999,116(2):394-400.
|
[13]JICAI Z,ZONGTAO Y,JUN L,et al.Persistent infection of hepatitis B virus is involved in high rate of p16 methylation in hepatocellular carcinoma[J].Mol Carcinog,2006,45(7):530-536.
|
[14]BHAGAT R,KUMAR SS,VADERHOBLI S,et al.Epigenetic alteration of p16 and retinoic acid receptor beta genes in the development of epithelial ovarian carcinoma[J].Tumour Biol,2014,35(9):9069-9078.
|
[15]LEE MH,NA H,NA TY,et al.Epigenetic control of metastasisassociated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis[J].Oncogenesis,2014,3:e88.
|
[16]PROTZER U.Hepatitis:Epigenetic control of HBV by HBx proteinreleasing the break?[J].Nat Rev Gastroenterol Hepatol,2015,12(10):558-559.
|
[17]VALDESPINO-GOMEZ VM,VALDESPINO-CASTILLO VE.Targeted epigenetic therapy of cancer.Achievements and perspectives[J].Cir Cir,2012,80(5):470-480.
|
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