Effects of early intervention with Huoxueqingjie decoction on hemorheological parameters and D- dimer,thromboxane A2,and prostaglandin I2 levels in patients with severe acute pancreatitis

Objective To investigate the effects of early intervention with Huoxueqingjie decoction on hemorheological parameters and the levels of thromboxane A_2( TXA_2) and prostaglandin I_2( PGI_2) in patients with severe acute pancreatitis. Methods A total of 50 patients with severe acute pancreatitis( SAP) who were hospitalized in our hospital from January to December,2013 were randomly divided into treatment group and control group. The patients in the two groups were given symptomatic / supportive treatment,and those in the treatment group were given Huoxueqingjie decoction twice a day through a spiral nasointestinal tube,with a course of the treatment of 1 week. Blood amylase,hemorheological parameters,and the levels of D- dimer,TXA_2,and PGI_2 were measured before treatment and on the 7th day of treatment. Comparison of normally distributed continuous data between groups was performed by t test,and comparison of categorical data between groups was conducted by chi- square test. Results Compared with the control group,the treatment group had a significant increase in overall response rate on the 7th day of treatment( 64% vs 88%,χ~2= 3. 947,P = 0. 047). On the 7th day of treatment,both groups showed significant reductions in the serum levels of amylase,D- dimer,and TXA2 and TXA_2/ PGI_2ratio( all P < 0. 01),and the treatment group had significantly lower levels of these parameters than the control group( P < 0. 05 or P < 0. 01). On the 7th day of treatment,both groups showed a significant increase in PGI_2 level( both P < 0. 01),and the treatment group had a significantly higher PGI_2 level than the control group( P < 0. 01). On the 7th day of treatment,both groups showed significant reductions in all hemorheological parameters,high,middle,and low blood viscosity,plasma viscosity,whole blood reduced viscosity at high or low shear rate,hematocrit,erythrocyte rigidity index,erythrocyte aggregation index,equation K value of erythrocyte sedimentation rate,erythrocyte deformation index,and erythrocyte sedimentation rate( P < 0. 05 or P < 0. 01),and the treatment group had significantly lower hemorheological parameters than the control group( P < 0. 05 or P < 0. 01). Conclusion Traditional Chinese medicine Huoxueqingjie decoction can improve hemorheological parameters,inhibit the increase in D- dimer,maintain the balance between TXA2 and PGI2and therefore plays an important role in the treatment of SAP.