Correlation between HBsAg,prothrombin time activity,and indocyanine green retention rate at 15 minutes in patients with HBeAg-positive chronic HBV infection

Objective To investigate the correlation between HBsAg,prothrombin time activity( PTA),and indocyanine green retention rate at 15 minutes( ICG R15) in patients with HBeAg- positive chronic HBV infection. Methods A total of 92 patients with HBeAg- positive chronic HBV infection who were admitted to The First Hospital of Lanzhou University from December 2015 to April 2016 were enrolled and divided into chronic hepatitis B( CHB) group( 24 patients),compensated liver cirrhosis group( 38 patients),and decompensated liver cirrhosis group( 30 patients). Serum HBsAg quantitation,PTA test,and liver reserve function test( ICG R15)were performed for all patients. The chi- square test was used for comparison of categorical data between groups,an analysis of variance was used for comparison of continuous data between multiple groups,and a Pearson correlation analysis was also performed. Results There were significant differences between the three groups in serum HBsAg quantitation( 3. 82 ± 0. 43 log10 IU / ml vs 2. 88 ± 0. 36 log10 IU / ml vs 2. 60 ± 0. 27 log10 IU / ml,F = 25. 19,P < 0. 001),ICG R15( 7. 51% ± 3. 10% vs 9. 57% ± 8. 18% vs 24. 13% ± 14. 28%,F = 24. 00,P = 0. 001),and PTA( 81. 00% ± 17. 62% vs 83. 08% ± 9. 64% vs 62. 32% ± 16. 90%,F = 13. 42,P = 0. 009). The correlation analysis showed that PTA was negatively correlated with ICG R15 in all three groups( r =- 0. 948,- 0. 602,and- 0. 735,all P < 0. 01). In the compensated liver cirrhosis group and decompensated liver cirrhosis group,HBsAg was positively correlated with PTA( r = 0. 410 and 0. 473,both P < 0. 05) and negatively correlated with ICG R15( r =- 0. 427 and- 0. 768,P < 0. 01). Conclusion In HBeAg positive patients,there are certain correlations between HBsAg,PTA,and ICG R15,which,to a certain degree,reflects the liver reserve function in patients with chronic HBV infection.