中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2016

Clinical effect of liver cancer resection combined with selective decongestive devascularization in treatment of primary liver cancer complicated by portal hypertension

DOI: 10.3969/j.issn.1001-5256.2016.11.023
  • Published Date: 2016-11-20
  • Objective To investigate the clinical effect of liver cancer resection combined with selective decongestive devascularization in the treatment of primary liver cancer complicated by portal hypertension. Methods A retrospective analysis was performed for the clinical data of 60 patients with primary liver cancer complicated by portal hypertension who were treated in The Second People's Hospital of Zhenjiang from March 2013 to February 2016. According to the surgical procedure,the patients were divided into group A( 32 patients) and group B( 28 patients). The patients in group A were given liver cancer resection combined with splenectomy,and those in group B were given liver cancer resection combined with selective decongestive devascularization. The patients' general status in the perioperative period were observed,and immune function parameters and liver function parameters were compared between the two groups before and after surgery,as well as the incidence of complications. The t- test was used for comparison of continuous data between groups,and the chi- square test was used for comparison of categorical data between groups. Results Compared with group A,group B had a significantly longer time of operation( 135. 27 ± 15. 13 min vs 118. 35 ± 12. 56 min,t =- 4. 733,P < 0. 001) and a significantly shorter length of hospital stay( 14.28 ± 2. 95 d vs 16. 37 ± 3. 42 d,t = 2. 516,P = 0. 007). At 1 month after surgery,group B had significantly higher levels of Ig G,Ig M,and Ig A than group A [( 14. 98 ± 3. 12) vs( 12. 51 ± 2. 75) 、( 2. 79 ± 1. 13) vs( 2. 25 ± 1. 02),( 2. 42 ± 0. 79) vs( 1. 87 ± 0. 82),t =- 3.260,- 1. 945,and- 2. 636,P < 0. 001, = 0. 028,and < 0. 005]. At 1 month after surgery,both groups showed significant increases in platelet count( t =- 89. 590 and- 20. 261,both P < 0. 001),and group A showed a significantly greater increase than group B [( 302. 46± 15. 08) × 109/ L vs( 80. 25 ± 5. 68) × 109/ L,t = 73. 481,P < 0. 001]. There were no significant differences in the incidence rates of postoperative complications between the two groups( 18. 75% vs 17. 86%,χ2= 0. 008,P = 0. 929). Conclusion Liver cancer resection combined with selective decongestive devascularization can improve liver function and maintain good immune function in patients,and therefore,it has an important clinical application value.

     

  • 第1例腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)于20世纪80年代末被报道,其具有手术创伤小、术后恢复快、疗效好等优点,目前在世界范围内得到了广泛应用;而胆总管损伤是LC的常见并发症,发生率为0.4%~0.6%[1-6],可导致严重后果。如胆管壁损伤需要胆管缝合或T管引流,而胆总管横断伤则需要胆总管空肠吻合术或Roux-en-Y吻合术。而这些补救措施往往需要将LC中转为开放手术,极大地增加患者的经济负担和身体疼痛。考虑到胆总管损伤的严重性和普遍性,有效预防胆总管损伤的方法亟待应用。

    引起胆总管损伤的原因多样,包括胆道解剖变异、胆囊炎反复发作引起胆总管变形、操作人员经验不足及器械不当等[7-12]。可以认为,准确识别胆总管是预防胆总管损伤的有效方法。因而从20世纪80年代至今,人们为准确识别胆总管和胆囊管做出了巨大努力;尝试过的方法如术中X线造影,但不易操作,且X线会给患者和操作者带来辐射风险[13];而术中超声成像也不易用于胆总管的识别。

    近红外造影术于近年来兴起,其中吲哚菁绿(indocyanine green, ICG)造影术最为简便[14],被广泛应用于各类外科手术,包括肿瘤边界识别、甲状旁腺保护、肝段切除、乳腺癌前哨淋巴结活检等[15]。与其他方法相比,ICG造影安全性高。据报道[16],仅0.001 67%的患者对ICG发生过敏反应。且ICG使用方便,可于术前经静脉注射,如于术前24 h予ICG 25 mg以显影肝癌边界;术前50 s给予7.5 mg ICG以鉴别甲状旁腺;术前10 min予ICG 1 mg协助乳腺癌前哨淋巴结活检[15];离断操作前3 min予ICG 5 mg行肠血运灌注评估等[17]

    此前已有研究[18-19]对术中ICG胆道造影鉴别胆总管和胆囊管方法的有效性和安全性进行了评估,但此法的长期效果仍需进一步确认。本研究首次应用倾向评分匹配法比较了ICG胆道造影组和常规LC组患者中胆总管损伤的发生率,探讨ICG胆道造影的应用效果。

    选取珠海市人民医院2021年4月—6月行LC患者。纳入标准:经超声、CT或MRI检查并结合病史确诊为胆囊良性疾病需行LC的患者。排除标准:急性胆囊炎、胰腺炎、血管性胆囊炎和胆总管结石;胆囊穿刺引流,引流管未拔出者;有心脏、肺部等基础疾病,不宜手术者;美国麻醉师学会评分≥2分。

    将同意接受ICG胆道造影的患者纳入ICG胆道造影组,其余纳入常规LC对照组。常规LC组患者用腹腔镜白光,ICG胆道造影组用近红外光检查胆总管、胆囊管和胆囊。采用倾向评分匹配法对两组患者进行基线指标的平衡。

    所有患者术前均行心电图、胸部X线检查、超声、CT、血型、血常规、凝血功能、感染性疾病筛查、肝肾功能检查等。所有检查结果正常的患者可安排手术。有其他基础疾病的患者,需经相关专科和麻醉科会诊确认可耐受全麻。对所有患者术前均进行LC围手术期注意事项的宣教;另对ICG胆道造影组患者进行ICG胆道造影知识宣教;其他术前准备按上腹部手术常规进行。

    两组患者均行LC。患者头部抬高30°,身体左倾30°。全麻后建立静脉通路,用插入式Veress针头向腹腔内注入CO2。于脐下行一1 cm切口。经脐下套管针导入腹腔镜。在胆囊的体表投影处行一0.5 cm切口,于剑突下行一1 cm切口。将腹腔镜器械置入腹腔,解剖Calot三角。夹闭切断胆囊管和胆囊动脉。取胆囊送病理检查。关闭皮肤切口,视情况放置腹腔引流管(图 1)。

    图  1  ICG造影引导下腹腔镜胆囊切除术过程
    注:a、b,荧光及白光下分离胆囊三角周围粘连的过程;c、d,荧光及白光下分离胆囊床及游离胆囊过程;e、f,荧光及白光下结扎胆囊管过程。

    对ICG胆道造影组患者于术前30 min(切皮前60 min)静脉注射ICG (瑞度,丹东医药)0.4 mg·kg-1·mL-1(基于ICG在血液中浓度于2 h达到最大值的原理确定此给药时间)。

    荧光成像系统由近红外光源、控制手柄、腹腔镜、脚踏开关、设备摄像机和显示屏组成。该系统可作为常规腹腔镜手术系统呈现全彩色图像,并可在操作者踩下脚踏开关后发出波长约800 nm的近红外光用于ICG胆道造影;专门设计的腹腔镜可传输近红外光;通过操作控制手柄,术者可拍摄术中ICG胆道造影的照片或视频。

    ICG胆道造影组在夹闭胆囊管前后,应用ICG胆道造影排除异位胆管的存在,并区分胆总管和胆囊管。所有的手术操作完成后,2名术者需用ICG胆道造影2次检查胆囊管残端,确保胆总管完好。比较2组术中出血量、手术时间、术后住院时间及胆总管损伤发生率。

    本研究方案经由珠海市人民医院伦理委员会审批,批号:2019-02;并在中国临床试验注册中心注册,注册号:ChiCTR1900024594。

    采用SPSS 25.0进行统计分析。正态分布的计量资料采用x±s表示,2组间比较采用t检验;计数资料2组间比较采用χ2检验。多元逻辑回归模型评估每位受试者的倾向性得分。协变量包括以下基线特征:年龄、性别、复杂性胆结石等。P<0.05为差异有统计学意义。

    共纳入68例行LC患者,其中ICG胆道造影组12例,常规LC组56例,患者基线特征如表 1所示。行倾向评分匹配后,获得12对患者。匹配后,两组患者的基线变量差异被有效校正,两组患者特征比较,差异均无统计学意义(P值均>0.05)。

    表  1  ICG胆道造影组和常规LC组患者匹配前后基线特征比较
    项目 匹配前 匹配后
    常规LC组(n=56) ICG胆道造影组(n=12) 标准化差异(%) P 常规LC组(n=12) ICG胆道造影组(n=12) 标准化差异(%) P
    年龄(岁) 53.2±6.5 63.7±5.1 19.7 0.001 57.1±8.3 57.2±9.6 0.18 0.372
    男/女(例) 39/27 8/4 28.3 0.001 8/4 8/4 0 >0.05
    复杂性胆结石(例) 21 3 33.3 0.006 3 3 0 >0.05
    下载: 导出CSV 
    | 显示表格

    ICG胆道造影组和常规LC组治疗结果见表 2,ICG胆道造影组术中出血量、手术时间、术后住院时间、胆总管损伤发生率与常规LC组比较,差异均有统计学意义(P值均<0.05)。常规组出现胆总管周围组织出血1例(8.3%),患者进行了止血药保守处理后于术后1周内康复。所有切除的胆囊均显示良性病理结果。

    表  2  ICG胆道造影组和常规LC组患者的手术效果比较
    项目 ICG胆道造影组(n=12) 常规LC组(n=12) 统计值 P
    手术时间(min) 20.2±1.6 48.3±5.1 t=-19.856 <0.01
    术中出血量(mL) 3.1±0.9 10.8±2.3 t=-22.709 <0.01
    胆总管相关损伤[例(%)] 0 1(8.3) χ2=1.287 0.013
    住院时间(d) 1.2±0.3 2.3±0.8 t=-19.507 <0.01
    下载: 导出CSV 
    | 显示表格

    常规LC在手术过程中有发生胆总管损伤的风险,而胆总管的医源性损伤主要与外科医师对胆道的认识不准确有关。ICG胆道造影可通过显示胆囊管和胆总管的结构来预防术中胆总管损伤;本项研究表明,在LC中,ICG胆道造影可确保对胆总管和胆囊管的准确识别,有效区分胆总管与胆囊管的结构,准确解剖Calot三角,从而有效保护胆总管。

    ICG过敏反应是最严重的并发症,但发生率极低;Perry等[16]研究显示,ICG过敏反应仅为1/80 000,并且术前碘过敏实验可预测及预防ICG过敏的发生。

    本研究结果显示,ICG胆道造影组中无患者发生胆总管损伤;常规组出现胆总管周围组织出血1例,患者进行了止血保守处理后于术后1周内康复。且两组在术中手术时间、术中出血量、术后住院时间等方面均有显著性差异。究其原因,常规LC常需剥离胆管周围组织以显示其形态及结构,此过程将不可避免造成失血,并延长手术时间;而ICG胆道造影可直接显示胆总管及胆囊管结构,无需剥离周围组织,从而避免术中出血,并缩短手术时间,显示出ICG胆道造影在LC中的显著优势。

    本研究为ICG胆道造影预防LC术中胆总管损伤的有效性和安全性提供了依据。由于ICG胆道造影具有效果好、精密性和准确性高、安全性强、可对狭窄胆道进行显影等优点,有望成为LC治疗胆囊结石时重要的辅助方法。然而本研究的样本量较少,需在未来招募更多患者、增加病例数量以更进一步的深入研究。

  • [1]LIU HL,WU XL,CAI GZ,et al.Minimally invasive treatment of small hepatocellular carcinoma in the deep portion of the liver complicated by portal hypertension:an analysis of 46cases[J].Clin J Curr Adv Gen Surg,2015,18(3):238-240.(in Chinese)刘洪亮,吴晓龙,蔡广臻,等.微创治疗肝脏深部微小肝癌合并门静脉高压46例分析[J].中国现代普通外科进展,2015,18(3):238-240.
    [2]LI C,ZHANG QY,SUN KL,et al.Application of hepaticresection combined with selective decongestive devascularization of gastrosplenic region in hepatocellular carcinoma with moderate/severe portal hypertension[J].J Hepatopancreatobiliary Surg,2015,27(1):5-8.(in Chinese)李仓,张启瑜,孙克龙,等.肝癌切除联合选择性减断流术在原发性肝癌合并中重度门静脉高压症中的应用[J].肝胆胰外科杂志,2015,27(1):5-8.
    [3]Chinese Society of Liver Cancer,Chinese Anti-Cancer Association;Liver Cancer Study Group,Chinese Society of Hepatology,Chinese Medical Association;Chinese Society of Pathology,Chinese Anti-Cancer Association,et al.Evidence-based practice guidelines for the standardized pathological diagnosis of primary liver cancer in China(2015 update)[J].J Clin Hepatol,2015,31(6):833-839.(in Chinese)中国抗癌协会肝癌专业委员会,中华医学会肝病学分会肝癌学组,中国抗癌协会病理专业委员会,等.原发性肝癌规范化病理诊断指南(2015年版)[J].临床肝胆病杂志,2015,31(6):833-839.
    [4]MEHTA G,GUSTOT T,MOOKERJEE RP,et al.Inflammation and portal hypertension-the undiscovered country[J].J Hepatol,2014,61(1):155-163.
    [5]WU SS,LIU HY,CHEN QL,et al.Association between CD4+/CD8+ratio in peripheral blood before hepatectomy for liver cancer and patient prognosis[J].J Clin Hepatol,2015,31(12):2066-2069.(in Chinese)吴珊珊,刘鸿瑜,陈秋恋,等.肝癌切除术前外周血中CD4+/CD8+值与患者预后的相关性分析[J].临床肝胆病杂志,2015,31(12):2066-2069.
    [6]JIN G,NING LJ,LI GW,et al.Analysis of short-term effects of three-dimensional conformal radiotherapy with chemoembolization for hepatic carcinoma[J].Trauma and Grit Medicine,2015,3(3):169-171.(in Chinese)金罡,宁路江,李光炜,等.化学治疗栓塞术联合三维适形放射治疗原发性肝癌60例近期疗效观察[J].创伤与急危重病医学,2015,3(3):169-171.
    [7]HUANG DH,SHI JS,ZHANG CH.Usage analysis of human serum albumin in patients with liver cancer and liver cirrhosis after hepatectomy[J].J Clin Hepatol,2015,31(6):910-914.(in Chinese)黄东海,施建设,张诚华.原发性肝癌合并肝硬化患者肝切除术后人血白蛋白的应用分析[J].临床肝胆病杂志,2015,31(6):910-914.
    [8]ZHANG GS,HUANG H,ZHUANG LY.Splenic artery ligation for treatment of portal hypertension of patients with hepatic carcinoma[J/CD].Chin J Oper Proc Gen Surg:Electronic Version,2015,8(1):35-38.(in Chinese)张国松,黄海,庄林渊.肝癌合并门静脉高压术中脾动脉结扎的临床疗效观察[J/CD].中华普外科手术学杂志:电子版,2015,8(1):35-38.
    [9]LI W,WANG LZ,YANG XG,et al.Efficacy of transjugular intrahepatic portosystemic shunt with covered stents in the treatment of portal hypertension in 46 patients with primary hepatocellular carcinoma[J].Chin J Dig,2015,8(6):367-370.(in Chinese)李威,王黎洲,杨学刚,等.采用覆膜支架行经颈静脉肝内门体静脉分流术治疗原发性肝癌并门静脉高压46例疗效分析[J].中华消化杂志,2015,8(6):367-370.
    [10]HUANG SZ,ZHOU Q.Research advances in primary hepatocellular carcinoma complicated by portal vein tumor thrombus[J].J Hepatobiliary Surg,2015,23(2):155-157.(in Chinese)黄陕州,周奇.原发性肝细胞癌合并门静脉癌栓研究进展[J].肝胆外科杂志,2015,23(2):155-157.
    [11] GONG JB,MEI CQ,JIANG JX.Clinical efficacy of re-modified sugiura procedure for portal hypertention[J].Chin J Dig Surg,2016,15(7):674-679.(in Chinese)龚江波,梅长青,江建新.再改良的Sugiura术治疗门静脉高压症的临床疗效[J].中华消化外科杂志,2016,15(7):674-679.
    [12]SHI G,LI JD,WANG XF,et al.Simultaneous hepatectomy and splenectomy for primary hepatocellular carcinoma accompanied with liver cirrhosis and hypersplenism[J].J North Sichuan Med Coll,2015,30(5):615-617.(in Chinese)石刚,李敬东,王小飞,等.联合肝脾切除在原发性肝癌合并肝硬化和脾功能亢进患者中的应用[J].川北医学院学报,2015,30(5):615-617.
    [13]LIU LX,YIN DL.Prevention and management of operative complications after hepatectomy for liver cancer[J/CD].Chin J Oper Proc Gen Surg:Electronic Version,2014,8(1):23-25.(in Chinese)刘连新,尹大龙.肝癌肝切除术后常见并发症与处理[J/CD].中华普外科手术学杂志:电子版,2014,8(1):23-25.
    [14]JIN H,ZHAO H,WANG B,et al.Clinical effect of selective hepatic inflow occlusion in left hemihepatectomy for primary liver cancer[J].Jiangsu Med J,2016,42(3):334-335.(in Chinese)金辉,赵华,王彬,等.选择性入肝血流阻断在原发性肝癌左半肝切除术中的临床效果[J].江苏医药,2016,42(3):334-335.
    [15]CAO JL,LU SC,ZENG DB,et al.Clinical analysis of splenectomy and selective devascularization based on intra-operative free portal pressure[J].Chin J Hepatobiliary Surg,2014,20(9):648-651.(in Chinese)曹技磊,卢实春,曾道炳,等.基于术中自由门静脉压测定的脾切除加选择性断流术的临床分析[J].中华肝胆外科杂志,2014,20(9):648-651.
    [16]XU JW,ZHANG YM,SONG Y,et al.Laparoscopic splenectomy and pericardial devascularization for portal hypertension[J].Chin J Min Inv Surg,2015,9(7):601-603.(in Chinese)徐继威,张耀明,宋越,等.完全腹腔镜下脾切除联合贲门周围血管离断术治疗门脉高压症[J].中国微创外科杂志,2015,9(7):601-603.
    [17] HUANG J,LONG K,SON M.Clinical efficacy of laparoscopic splenectomy combined with pericardial devascularization[J].Chin J Dig Surg,2016,15(7):684-688.(in Chinese)黄洁,龙奎,孙敏.腹腔镜脾切除联合贲门周围血管离断术的临床疗效[J].中华消化外科杂志,2016,15(7):684-688.
    [18]JIANG QF,WANG YX,LI K,et al.Laparoscopic splenectomy plus pericardial devascularization for portal hypertension[J].J Chin Practical Diagn Ther,2014,28(5):469-470.(in Chinese)姜青峰,王要轩,李珂,等.腹腔镜脾切除联合贲门周围血管离断术治疗门静脉高压症临床分析[J].中华实用诊断与治疗杂志,2014,28(5):469-470.
    [19]WANG WJ,TANG Y,FENG XS,et al.Experience on application of modified laparoscopic splenectomy and devascularization for portal hypertension[J/CD].Chin J Laparoscopic Surgery:Electronic Edition,2015,8(2):12-17.(in Chinese)王文静,唐勇,冯贤松,等.改良腹腔镜脾切除及贲门周围血管离断术的应用体会[J/CD].中华腔镜外科杂志:电子版,2015,8(2):12-17.
  • Relative Articles

    [1]Xuhong YANG, Yong YANG, Minglei WANG, Wenxiao LIU, Wanlong MA, Minxing WANG, Xiangchun DING, Xiaodong WANG. Value of blood ammonia and cholinesterase in the early diagnosis of liver cirrhosis with minimal hepatic encephalopathy[J]. Journal of Clinical Hepatology, 2023, 39(2): 339-344. doi: 10.3969/j.issn.1001-5256.2023.02.013
    [2]Yuhao YAO, Jiaxin ZHANG, Xiao XIA, Shun ZHU, Xiaoke LI, Yong'an YE. Effect of probiotics in preventing overt hepatic encephalopathy in patients with minimal hepatic encephalopathy: A Meta-analysis[J]. Journal of Clinical Hepatology, 2022, 38(11): 2505-2509. doi: 10.3969/j.issn.1001-5256.2022.11.013
    [3]Teng WANG, Yijing ZHU, Shousong ZHAO. Value of Stroop test in the diagnosis of minimal hepatic encephalopathy[J]. Journal of Clinical Hepatology, 2022, 38(4): 828-831. doi: 10.3969/j.issn.1001-5256.2022.04.017
    [4]Xichen LIU, Yiying WANG, Manman TONG, Junjie QIN. Biomarkers for the early diagnosis of hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(1): 176-179. doi: 10.3969/j.issn.1001-5256.2021.01.038
    [5]ZHANG QinFu, HAN HuanQin, ZHENG WeiQiang. Serum biomarkers for the early diagnosis of minimal hepatic encephalopathy[J]. Journal of Clinical Hepatology, 2020, 36(12): 2819-2821. doi: 10.3969/j.issn.1001-5256.2020.12.037
    [6]Zhao YunSheng, Zhang LiNa, Huo LiJing, Pei Liu, Li QiuPing, Li HongChen, Jin Liang. Clinical value of fucosylated Golgi protein 73 in differential diagnosis of small hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2018, 34(8): 1707-1711. doi: 10.3969/j.issn.1001-5256.2018.08.023
    [7]Luo XinChen, Zhou YouQian. Increasing early diagnosis of primary liver cancer by improving the compliance with regular screening in the high-risk population[J]. Journal of Clinical Hepatology, 2018, 34(8): 1788-1792. doi: 10.3969/j.issn.1001-5256.2018.08.044
    [8]Chen MinHua, Wu Wei. Value of contrast-enhanced ultrasound in early diagnosis of liver cancer and radiofrequency ablation treatment[J]. Journal of Clinical Hepatology, 2017, 33(7): 1211-1213. doi: 10.3969/j.issn.1001-5256.2017.07.002
    [9]Wang Ting, Liu Mei, Dong Lei, Duan ZhongPing. Application of tumor-associated antigens and their autoantibodies in early diagnosis of hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2016, 32(7): 1418-1421. doi: 10.3969/j.issn.1001-5256.2016.07.047
    [10]Li Mi, Nie QingHe. Accuracy of Fibro Scan for diagnosis of primary liver cancer: a Meta-analysis[J]. Journal of Clinical Hepatology, 2016, 32(2): 312-316. doi: 10.3969/j.issn.1001-5256.2016.02.023
    [11]Zhu Chen, Sun YuanYuan, Jin Yan. Values of serum AFP, GGTⅡ and GP73 in diagnosis of primary hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2014, 30(10): 1064-1066. doi: 10.3969/j.issn.1001-5256.2014.10.022
    [12]Gao HaiFeng. Value of combined detection of serum AFP and GP73 in early diagnosis of hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2014, 30(7): 660-662. doi: 10.3969/j.issn.1001-5256.2014.07.022
    [13]Zhu MingYu, Chen Jie, Zhang XinXin. Research advances in serum biomarkers for early diagnosis of hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2014, 30(10): 1091-1093. doi: 10.3969/j.issn.1001-5256.2014.10.029
    [14]Chen YangQin, Li Peng, Li Lei, Li Bing, Ding HuiGuo. Early diagnosis of nonalcoholic fatty liver cirrhosis[J]. Journal of Clinical Hepatology, 2014, 30(12): 1357-1360. doi: 10.3969/j.issn.1001-5256.2014.12.031
    [15]Li HaiPing, Gao Bo, Yu ZongTao, Liu JiuBo, Zhang JiCai. Significance of detection of multigene methylation in liver cancer tissue for early diagnosis of liver cancer[J]. Journal of Clinical Hepatology, 2013, 29(8): 624-626. doi: 10.3969/j.issn.1001-5256.2013.08.018
    [16]Ma QianYun, Zhu GeYuZheng. Diagnostic value of critical flicker frequency in minimal hepatic encephalopathy[J]. Journal of Clinical Hepatology, 2012, 28(7): 559-561.
    [17]Zhang ChunHua. Application of mass spectrometry technique in the diagnosis of metabolic liver disease in children[J]. Journal of Clinical Hepatology, 2011, 27(7): 709-717+728.
    [18]Wang YuMing, Yan ZeHui. The new concepts on hepatic encephalopathy[J]. Journal of Clinical Hepatology, 2010, 26(6): 568-574.
    [19]Wang Yu, Po YunFeng, Xu XianJi. A retrospective analysis of 74 patients with hipatic encephalopathy[J]. Journal of Clinical Hepatology, 2005, 21(3): 166-167.
  • Cited by

    Periodical cited type(12)

    1. 徐元,章波. 吲哚青绿近红外荧光胆道造影指导腹腔镜胆囊切除术治疗胆囊结石患者疗效研究. 实用肝脏病杂志. 2024(01): 141-144 .
    2. 杨铁健,李文奇,张开明,张俊杰. 吲哚菁绿荧光成像技术指导难治性胆囊切除术的前瞻性研究. 肝胆外科杂志. 2024(01): 35-39 .
    3. 李昌旭,李学民,梁占强,段希斌,杨鹏生. 吲哚菁绿荧光导航在老年急性胆囊炎患者经皮经肝胆囊穿刺引流术后腹腔镜胆囊切除术中的应用. 临床肝胆病杂志. 2023(04): 885-891 . 本站查看
    4. 陈镜宇,李达,徐鹏,林家嘉,佟德明,石三宝,张成. 小野寺预后营养指数对腹腔镜下直肠癌根治术后并发症预测价值研究. 临床军医杂志. 2023(04): 357-361 .
    5. 姬文超,韩瑞,牛莉莉,程少华. 吲哚菁绿荧光成像技术在腹腔镜胆囊切除术中的应用效果. 中国医学创新. 2023(16): 163-166 .
    6. 施舒鹏,常久翔,曾陶飞,何浩,尹大龙. 基于Cite Space文献计量法肝癌微创治疗的可视化分析. 中华消化外科杂志. 2023(09): 1139-1146 .
    7. 汪鑫,杨云,汪越,詹锐,张晓琴,崔巍. 不同方式给予右美托咪定在腹腔镜胆囊切除术应用效果比较. 临床军医杂志. 2023(12): 1258-1260 .
    8. 陆乔友,寸冬云,虞弘,郭鹏恒,田大广. ICG荧光胆道造影在胆囊结石合并胆囊炎患者LC术中的应用. 中华肝脏外科手术学电子杂志. 2023(03): 284-288 .
    9. 张建康,李涛,秦锡虎,吴宝强. 吲哚菁绿荧光胆道成像技术辅助腹腔镜残余胆囊结石切除:1例报道. 手术电子杂志. 2023(06): 76-77 .
    10. 舒杰,张昊翔,李建伟,李林,常清春,索朗旦增,曾继峰,郑芳芳,曹利,郑树国. 西藏高海拔地区急性结石性胆囊炎的临床特征及手术疗效分析. 中华消化外科杂志. 2022(07): 917-922 .
    11. 李敬东,黄徐建. 腹腔镜肝切除术中医源性胆道损伤的病因及防治策略. 中华肝脏外科手术学电子杂志. 2022(04): 335-337 .
    12. 王超群,宋清怡,姜启哲,崔云凡,殷保兵. ICG荧光显像技术引导下精准肝肿瘤切除术的现状与未来. 中华肝脏外科手术学电子杂志. 2022(04): 342-346 .

    Other cited types(5)

  • 加载中
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 6.1 %FULLTEXT: 6.1 %META: 91.7 %META: 91.7 %PDF: 2.1 %PDF: 2.1 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 5.2 %其他: 5.2 %其他: 0.6 %其他: 0.6 %China: 0.2 %China: 0.2 %India: 0.2 %India: 0.2 %Russian Federation: 0.2 %Russian Federation: 0.2 %United States: 0.2 %United States: 0.2 %上海: 3.1 %上海: 3.1 %中卫: 0.4 %中卫: 0.4 %兴安盟: 0.2 %兴安盟: 0.2 %北京: 9.4 %北京: 9.4 %南宁: 0.2 %南宁: 0.2 %吉林: 0.8 %吉林: 0.8 %哥伦布: 0.2 %哥伦布: 0.2 %张家口: 2.5 %张家口: 2.5 %新乡: 0.2 %新乡: 0.2 %昌吉: 0.2 %昌吉: 0.2 %杭州: 0.4 %杭州: 0.4 %绍兴: 0.2 %绍兴: 0.2 %芒廷维尤: 47.8 %芒廷维尤: 47.8 %芝加哥: 0.2 %芝加哥: 0.2 %莫斯科: 1.7 %莫斯科: 1.7 %西宁: 25.0 %西宁: 25.0 %镇江: 0.2 %镇江: 0.2 %长春: 0.4 %长春: 0.4 %长沙: 0.2 %长沙: 0.2 %长治: 0.2 %长治: 0.2 %青岛: 0.2 %青岛: 0.2 %其他其他ChinaIndiaRussian FederationUnited States上海中卫兴安盟北京南宁吉林哥伦布张家口新乡昌吉杭州绍兴芒廷维尤芝加哥莫斯科西宁镇江长春长沙长治青岛

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2158) PDF downloads(433) Cited by(17)
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return