Effect of Buqi Huoxue decoction on hemodynamics and liver fibrosis indices in hepatitis B patients with cirrhotic portal hypertension

Objective To investigate the effect of Buqi Huoxue decoction on hemodynamics and liver fibrosis indices in hepatitis B patients with cirrhotic portal hypertension.Methods A total of 79 patients with hepatitis B cirrhosis who were admitted to The People's Hospital of Qingyuan District from December 2013 to August 2015 were enrolled and randomly divided into study group( 41 patients) and control group( 38 patients).The patients in both groups were given oral entecavir( 0.5 mg,once a day) and bicyclol tablets( 25 mg,three times a day);the patients in the control group were given propranolol( 10 mg,three times a day) in addition,and those in the study group were given Buqi Huoxue decoction in addition.The course of treatment was 12 weeks for both groups.The hemodynamics and liver fibrosis indices were compared between the two groups before treatment and after 12 weeks of treatment.The t- test was used for comparison of continuous data between groups,and the chi- square test was used for comparison of categorical data between groups.Results After 12 weeks of treatment,both groups had significant reductions in diameter of the portal vein,diameter of the splenic vein,and portal vein flow and a significant increase in portal vein blood flow velocity( t = 3.847,4.672,3.524,5.237,3.578,3.829,3.468,and 3.673,P = 0.041,0.036,0.047,0.032,0.045,0.042,0.048,and 0.046),and the study group had significantly greater changes in these parameters compared with the control group( diameter of the portal vein:12.86 ± 2.34 mm vs 13.65 ± 2.45 mm,t = 3.725,P = 0.044;diameter of the splenic vein:9.50 ± 1.26 mm vs 11.15 ± 1.37 mm,t =- 6.672,P = 0.012;portal vein flow:1.23 ± 0.35 L / min vs 1.38 ± 0.44 L / min,t =-3.521,P = 0.047;portal vein blood flow velocity:19.50 ± 4.65 cm / s vs 17.57 ± 2.40 cm / s,t =- 6.225,P = 0.024).After 12 weeks of treatment,both groups had reductions in the four liver fibrosis indices hyaluronic acid,laminin,procollagen type Ⅲ,and collagen typeⅣ,and the study group had significantly greater reductions than the control group( hyaluronic acid:285.2 ± 53.4 μg /L vs 347.5 ± 63.4μg /L,t =- 7.252,P = 0.012;laminin:89.5 ± 25.6 μg /L vs 116.5 ± 29.7 μg /L,t =- 6.503,P = 0.018;procollagen type Ⅲ:63.5± 20.6 μg / L vs 98.7 ± 28.4 μg / L,t =- 5.279,P = 0.031;collagen type Ⅳ:85.5 ± 23.7 μg / L vs 122.5 ± 26.4 μg / L,t =- 6.977,P = 0.015).No patient experienced adverse drug reactions during the treatment.Conclusion Buqi Huoxue decoction can significantly improve hemodynamics and serum hepatic fibrosis indices in patients with cirrhotic portal hypertension.