中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 10
Oct.  2018

Association between MBOAT7 rs641738 polymorphism and nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2018.10.021
Research funding:

 

  • Published Date: 2018-10-20
  • Objective To investigate the association between MOBAT7 rs641738 polymorphism and the development of NAFLD in the Chinese Han population in Qingdao, China, and to provide a theoretical basis for the prevention and treatment of NAFLD and its complication.Methods A total of 113 NAFLD patients who were treated in Qingdao Municipal Hospital and 74 healthy controls were enrolled in this study. Blood samples were collected, DNA was extracted, and PCR and time-of-flight mass spectrometry were used to determine the genotype of MBOAT7 rs641738. The chi-square test was used to determine whether the distribution of genotypes met the Hardy-Weinberg equilibrium, in order to assess the group representativeness of samples. Clinical data and biochemical results including liver function were collected.The chi-square test was used for comparison of sex and genotype and allele frequencies between the two groups. The independent samples t-test and Wilcoxon rank sum test were used for comparison of continuous data between the two groups. The relative risk of NAFLD associated with gene polymorphisms was expressed as odds ratio ( OR) and 95% confidence interval ( CI) , and the non-conditional logistic regression model was used to calculate OR and 95% CI. Results There was no significant difference in the distribution of CC, CT, and TT genotypes of MBOAT7 rs641738 between the NAFLD group and the control group ( χ2= 0. 157, P = 0. 692) , and there was also no significant difference in the distribution of C and T alleles between the two groups ( χ2= 0. 365, P = 0. 546) . The non-conditional logistic regression analysis showed that the carriers with CC + CT genotypes of MBOAT7 rs641738 had a similar risk of NAFLD as those with CC genotype ( OR = 0. 923, 95% CI: 0. 685-1. 245, P = 0. 692) ; there was also no significant difference after adjustment for sex, age, and body mass index ( corrected OR = 0. 893, 95% CI: 0. 652-1. 223, P = 0. 481) . In the NAFLD group, the carriers with CC + CT genotypes had significantly lower levels of total cholesterol and low-density lipoprotein than those with CC genotype ( t =-2. 348 and-2. 113, P = 0. 021 and0. 037) , and there were no significant differences in the other indices ( all P > 0. 05) . Conclusion There is no significant association between MBOAT7 rs641738 polymorphism and the risk of NAFLD in the Chinese Han population in Qingdao.

     

  • [1]COHEN JC, HORTON JD, HOBBS HH.Human fatty liver disease:Old questions and new insights[J].Science, 2011, 332 (6037) :1519-1523.
    [2]LI SP, WANG QC.Progress of the epidemiology of non-alcoholic fatty liver disease[J].Chin J Gastroenterol Hepatol, 2017, 26 (10) :1085-1087. (in Chinese) 李生鹏, 王全楚.非酒精性脂肪性肝病的流行病学进展[J].胃肠病学和肝病学杂志, 2017, 26 (10) :1085-1087.
    [3]SEVERSON TJ, BESUR S, BONKOVSKY HL.Genetic factors that affect nonalcoholic fatty liver disease:A systematic clinical review[J].World J Gastroenterol, 2016, 22 (29) :6742-6756.
    [4]DONGIOVANNI P, VALENTI L.Genetics of nonalcoholic fatty liver disease[J].Metabolism, 2016, 65 (8) :1026-1037.
    [5]HU ZJ, ZHANG J.Current status of research on nonalcoholic fatty liver disease in China[J].J Clin Hepatol, 2016, 32 (3) :552-555. (in Chinese) 胡中杰, 张晶.我国非酒精性脂肪性肝病的研究现状[J].临床肝胆病杂志, 2016, 32 (3) :552-555.
    [6]GIJON MA, RIEKHOF WR, ZARINI S, et al.Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils[J].J Biol Chem, 2008, 283 (44) :30235-30245.
    [7]LEE HC, INOUE T, IMAE R, et al.Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol[J].Mol Biol Cell, 2008, 19 (3) :1174-1184.
    [8]DAUWERSE JG, de VRIES BB, WOUTERS CH, et al.At (4;6) (q12;p23) translocation disrupts a membrane-associated O-acetyl transferase gene (MBOAT1) in a patient with a novel brachydactyly-syndactyly syndrome[J].Eur J Hum Genet, 2007, 15 (7) :743-751.
    [9]PEREZ-CHACON G, ASTUDILLO AM, BALGOMA D, et al.Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases[J].Biochim Biophys Acta, 2009, 1791 (12) :1103-1113.
    [10]LANDS WE.Metabolism of glycerolipides;a comparison of lecithin and triglyceride synthesis[J].J Biol Chem, 1958, 231 (2) :883-888.
    [11]ZARINI S, HANKIN JA, MURPHY RC, et al.Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells[J].Prostaglandins Other Lipid Mediat, 2014, 113-115:52-61.
    [12]KRAWCZYK M, RAU M, SCHATTENBERG JM, et al.Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity:A multicenter biopsy-based study[J].J Lipid Res, 2017, 58 (1) :247-255.
    [13]MANCINA RM, DONGIOVANNI P, PETTA S, et al.The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of european descent[J].Gastroenterology, 2016, 150 (5) :1219-1230.
    [14]THABET K, ASIMAKOPOULOS A, SHOJAEI M, et al.MBOAT7rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C[J].Nat Commun, 2016, 7:12757.
    [15]LIN YC, CHANG PF, CHANG MH, et al.Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children[J].Liver Int, 2018, 38 (7) :1300-1307.
    [16]Group of Fatty Liver and Alcoholic Liver Diseases, Society of Hepatology, Chinese Medical Association.Guidelines for management of non-alcoholic fatty liver disease[J].J Clin Hepatol, 2010, 26 (2) :120-124. (in Chinese) 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].临床肝胆病杂志, 2010, 26 (2) :120-124.
    [17]BUCH S, STICKEL F, TREPO E, et al.A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7as risk loci for alcohol-related cirrhosis[J].Nat Genet, 2015, 47 (12) :1443-1448.
    [18]LUUKKONEN PK, ZHOU Y, HYOTYLAINEN T, et al.The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans[J].J Hepatol, 2016, 65 (6) :1263-1265.
    [19]DONATI B, DONGIOVANNI P, ROMEO S, et al.MBOAT7rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals[J].Sci Rep, 2017, 7 (1) :4492.
  • Relative Articles

    [1]Decai KONG, Xiaojing ZHANG, Yangguang YUN, Haoyu DUAN, Junfeng YE. Risk factors for biliary stricture and prognosis after orthotopic liver transplantation[J]. Journal of Clinical Hepatology, 2024, 40(11): 2253-2259. doi: 10.12449/JCH241119
    [2]Bingbing ZHU, Jinxiang YANG, Qun ZHANG, Fangyuan GAO, Xianbo WANG. Risk factors for the 90-day prognosis of patients with type I hepatorenal syndrome and establishment of a predictive model[J]. Journal of Clinical Hepatology, 2022, 38(7): 1561-1565. doi: 10.3969/j.issn.1001-5256.2022.07.019
    [3]Wanshu LIU, Lijun SHEN, Qinghui ZHAI, Shaojie XIN, Shaoli YOU. Risk factors for acute variceal bleeding in acute-on-chronic liver failure and its influence on prognosis[J]. Journal of Clinical Hepatology, 2022, 38(11): 2532-2536. doi: 10.3969/j.issn.1001-5256.2022.11.018
    [4]Siqin LIU, Xiaomei WANG, Xia LI, Luwen LIANG, Ke WANG, Rui WANG. Covert hepatic encephalopathy in liver cirrhosis: Risk factors and prognosis[J]. Journal of Clinical Hepatology, 2022, 38(2): 359-364. doi: 10.3969/j.issn.1001-5256.2022.02.020
    [5]Ping ZHU, Heping ZHAO, Tao HAN, Qing YE, Tinghong LI, Huiling XIANG. Evaluation and influencing factors of the short-term prognosis of severe alcoholic hepatitis with different underlying liver diseases[J]. Journal of Clinical Hepatology, 2021, 37(2): 370-374. doi: 10.3969/j.issn.1001-5256.2021.02.024
    [6]Zhang DaLi, Feng DanNi, Zhang LiJuan, Tang RuJia, He Xi, Zhou Xia, Gao YinJie, Liu ZhenWen, Liu HongLing. Risk factors for recurrence after liver transplantation in patients with hepatocellular carcinoma and their prognosis[J]. Journal of Clinical Hepatology, 2020, 36(9): 1985-1989. doi: 10.3969/j.issn.1001-5256.2020.09.015
    [7]Li Ying, Zhan Jing, Wang ZhongFeng. Prognostic factors for patients with hepatitis B virus-related acute-on-chronic liver failure[J]. Journal of Clinical Hepatology, 2017, 33(3): 497-501. doi: 10.3969/j.issn.1001-5256.2017.03.020
    [8]Wang FengJiao, Liu MingJiang, Wu RuiHong, Niu JunQi. A multivariate logistic regression analysis of short-term prognosis of patients with hepatic encephalopathy[J]. Journal of Clinical Hepatology, 2017, 33(4): 711-714. doi: 10.3969/j.issn.1001-5256.2017.04.022
    [9]Cui YanPing, Li QingFang, Li QingYan, Liu ChunHua, Wang WeiHong, Yuan JianGuo, Wang SiKui. Logistic regression analysis of prognostic risk factors for hepatic encephalopathy[J]. Journal of Clinical Hepatology, 2016, 32(1): 135-138. doi: 10.3969/j.issn.1001-5256.2016.01.026
    [10]Shi XinXing, Zhang YanQiong, Zhu Peng, Yan GuoHua, Zhang ZhangJiang, Wang YuMing. Prognostic risk factors in patients with hepatitis B virus- related acute- on- chronic liver failure[J]. Journal of Clinical Hepatology, 2016, 32(4): 700-705. doi: 10.3969/j.issn.1001-5256.2016.04.018
    [11]Qiao LiNa, Dai GuangRong, Zhang Jin, Shen Ni. An epidemiological survey of prevalence and risk factors for fatty liver disease in adults residing in Yan'an,China[J]. Journal of Clinical Hepatology, 2015, 31(1): 82-87. doi: 10.3969/j.issn.1001-5256.2015.01.018
    [12]Chen YongFang, Wu ZhanJun. Pathogenesis and risk factors of cholesterol gallstones in patients with non- alcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2013, 29(12): 952-955. doi: 10.3969/j.issn.1001-5256.2013.12.021
    [13]Wu XiaoQing, Wan Hong. Causes of liver failure and impact analysis of prognostic risk factors[J]. Journal of Clinical Hepatology, 2013, 29(4): 294-296+304.
    [14]Zhang DongQing, Chen Li, Gan QiaoRong, Zhou Rui, Huang JianRong, Pan Chen. Prognostic factors for hepatitis B acute-on-chronic liver failure[J]. Journal of Clinical Hepatology, 2012, 28(10): 740-743.
    [15]Liu HongHong, Fu JunLiang, Fu BaoYun, Zhang Zheng, Xu RuoNan, Luo ShengQiang, Shi Ming, Li YongGang, Wang FuSheng. The pathogenesis and risk factors related to prognosis of primary biliary cirrhosis[J]. Journal of Clinical Hepatology, 2012, 28(2): 153-155.
    [16]Lu: RiYing, Li ShiXiong, Wu JiZhou, Zhu YuJia, Fu ShaoPing. Development of a prognostic factors model for severe hepatitis[J]. Journal of Clinical Hepatology, 2012, 28(10): 789-792.
    [17]Zhang YiNing, Du HongWei, Liu YanJun, Wang ChaoXia. The diagnosis and risk factors for evaluation of nonalcoholic fatty liver disease in children and adolescents[J]. Journal of Clinical Hepatology, 2011, 27(7): 690-693.
    [18]Liu XiaoYan, Li ShengMian, Yang Jian. The incidence and prognosis of non-alcoholic fatty liver disease in primary liver cancer 1293 cases[J]. Journal of Clinical Hepatology, 2010, 26(6): 641-643.
    [19]Chen MingWei, Yang MingGong, Wang YouMin, Wang ZhangJiang, Pan TianRong, Hu HongLin, Sun HaiYan. Risk factors analysis on nonalcoholic steatohepatitis in patients with type 2 diabetes[J]. Journal of Clinical Hepatology, 2004, 20(1): 44-45.
    [20]Ding HuiGuo, Gao GuiJu, Chen Tao, Jin Rui. Prognosis of Severe Types of Virous Hepatitis: Study on Mutiple Risk Factors.[J]. Journal of Clinical Hepatology, 2002, 18(5): 297-299.
  • Cited by

    Periodical cited type(4)

    1. 王静,王佳琪,陈芳,夏杰,李露锋,毛青. ALT正常的慢性乙型肝炎患者抗病毒治疗疗效和安全性的真实世界研究. 重庆医学. 2025(01): 138-141 .
    2. 何雄志. 红外肝病治疗仪联合富马酸丙酚替诺福韦治疗慢性乙型肝炎的临床效果. 中外医学研究. 2025(06): 36-39 .
    3. 唐海涛,王娴,周佳琦,王凤梅,张文华. 富马酸丙酚替诺福韦治疗初治失代偿期乙型肝炎肝硬化患者的临床研究. 肝脏. 2024(07): 830-833 .
    4. 付文鹏,慕少英. 富马酸丙酚替诺福韦治疗慢性乙型病毒性肝炎的临床疗效分析. 系统医学. 2024(23): 39-42 .

    Other cited types(2)

  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2670) PDF downloads(399) Cited by(6)
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return