Since the development of direct-acting antivirals( DAAs) for hepatitis C virus( HCV),more than 95% of the patients with hepatitis C can be cured,but a very small proportion of patients still face treatment failure. There are many reasons for treatment failure,among which HCV genotype and resistance-associated substitutions( RASs) in virus genes show a certain impact. This article mainly introduces the RASs associated with the NS5 B and NS5 A gene fragments in genotype 2/3 HCV,summarizes the distribution of RASs,and compares the difference in the distribution of RASs between previously untreated chronic hepatitis C patients and patients with treatment failure.
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