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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 7
Jul.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(7): 1734-1739

Role of lipopolysaccharide in the development and progression of liver cancer

DOI: 10.3969/j.issn.1001-5256.2023.07.032
  • 1.

    Department of Medical Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China

  • 2.

    College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100089, China

Research funding:

Youth Program of National Natural Science Foundation of China (82003211)

More Information
  • Corresponding author: DUAN Xuezhang, duanxuezhang2006@163.com (ORCID: 0000-0002-1941-9317)
  • Received Date: 2022-10-11
  • Accepted Date: 2022-11-14
  • Published Date: 2023-07-20
    Abstract
  • Liver cancer is an important public health issue worldwide. With the improvements in high-throughput sequencing and gene editing techniques in recent years, studies have further revealed the biological mechanism of intestinal microflora in the development, progression, and metastasis of liver cancer via the gut-liver axis, and in particular, it has been found that lipopolysaccharide, a component of the outer membrane of gram-negative bacteria, can cause downstream immune cascade reactions. This article reviews the possible mechanism of action of intestinal microflora lipopolysaccharide in the development and progression of liver cancer from the aspects of the association between intestinal environmental changes and liver cancer, immunoregulation by lipopolysaccharide, and preclinical treatment.

     

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