大鼠重症胰腺炎早期肝脏损害与门静脉血中TNF-α、IL-6的关系

In order to detect the relationship of TNF-α、IL-6 in portal vein and hepatic damage in experimental SAP rats, 30 male wistar rats were randomly divided into experimental and control group. Rats were sacrificed 3、6 and 12h after the operation. TNF-α and IL-6 levels were measured in the samples of portal vein and hepatic vein. AST and ALT levels were measured in the samples of femoral vein. With the development of AP, the concentration of serum AST and ALT were increased significantly in the experimental group compared with the control. TNF-α and Il-6 levels in the portal vein were much higher in the experimental group than those in the hepatic vein. Compared with the control group, TNF-α and IL-6 levels in the portal vein and hepatic vein were significantly increased in the experimental group. Conclusion: 1.Hepatic dysfunction occurred in SAP rats. 2.TNF-α and IL-6 levels in portal vein increased in SAP rats. 3.The degree of hepatic damage was related with the levels of TNF-α and IL-6 in portal vein.