The expression of suppressor of cytokine signaling-1 mRNA in the peripheral blood mononuclear cells of patients with chronic hepatitis B infection

Liu Mei; Zhang LiLi; Chen Ming; Pan XiuCheng; Li Li

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May 2011

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The expression of suppressor of cytokine signaling-1 mRNA in the peripheral blood mononuclear cells of patients with chronic hepatitis B infection

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Published Date: 2011-05-20

Abstract

Abstract

Objective To investigate the expression of suppressor of cytokine signaling-1 (SOCS-1) in the peripheral blood mononuclear cells (PBMCs) of patients with chronic hepatitis B (CHB) , and analyze the relationship between the expression and the degree of liver inflammation.Methods CHB patients were divided into three groups: mild group, moderate group and severe group respectively with 15 cases, 15cases of HBV carriers as carry group and 15 cases of healthy volunteers as control group.The PBMCs were separated by density gradient centrifugation and the lever of SOCS-1mRNA was determined by RT-PCR.Results The lever of SOCS-1 mRNA in the severe group (1.15±0.12) was significantly higher than that in control group (0.86±0.10) , carry group (0.89±0.18) and mild group (0.93±0.12) (q=4.183～5.472, P<0.01) .The expression of SOCS-1mRNA and the level of inflammation of the liver in CHB patients were positively correlated (rs=0.664, P=0.003) .Conclusion The lever of SOCS-1mRNA in PBMCs of CHB patients was releated to the degree of liver inflammation.
- hepatitis B,
- chronic,
- suppressor of cytokine signaling proteins

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References

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The expression of suppressor of cytokine signaling-1 mRNA in the peripheral blood mononuclear cells of patients with chronic hepatitis B infection

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The expression of suppressor of cytokine signaling-1 mRNA in the peripheral blood mononuclear cells of patients with chronic hepatitis B infection

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