The expression and significance of CXCL10 and CXCL11 in chronic hepatitis B patients

Zhu XianJin; Song YanFang; Cao YingPing; Xu WeiQun; Zhang ChenQing

Issue 8

Aug. 2011

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2011 > 27(8): 804-806

PDF( 1224 KB)

The expression and significance of CXCL10 and CXCL11 in chronic hepatitis B patients

Published Date: 2011-08-20

Abstract

Abstract

Objective To study the expression levels of CXCL10 and CXCL11 and its relationships with alanine aminotransferase (ALT) and HBV DNA in patients with chronic hepatitis B.Methods The serum levels of CXCL10 and CXCL11 were measured by enzyme-linked immunosorbent assay (ELISA) , the levels of HBV DNA were detected by real-time quantitative polymerase chain reaction (RT-PCR) .Serum ALT were tested with automatic biochemistry analyzer.Results The serum levels of CXCL10 and CXCL11 in the patients with chronic hepatitis B were (123.38±88.37) pg/ml and (129.24±82.79) pg/ml respectively, which was significantly higher than those in normal controls (P<0.05) .In patients with chronic hepatitis B, the serum levels of CXCL10 and CXCL11 were significantly correlated with the serum level of ALT (r=0.739 and 0.597 respectively, P<0.05) , while wasn't correlated with the serum level of HBV DNA (r=0.244 and 0.242 respectively, P>0.05) .Conclusion CXCL10 and CXCL11 play an important role in inflammatory and immune injury, which mediate the chronicity of hepatitis B.
- hepatitis B,
- chronic,
- chemokine CXCL10

FullText(HTML)

References(10)

References

[1] Oo YH, Adams DH. The role of chemokines in the recruitment of lymphocytes to the liver[J]. J Autoimmun, 2010, 34 (1) : 45-54.

[2] Laing KJ, Secombes CJ. Chemokines[J]. Dev Comp Immunol, 2004, 28 (5) : 443-460.

[3] Heydtmann M, Adams DH. Chemokines in the immunopathogenesis of hepatitis C infection[J]. Hepatology, 2009, 49 (2) : 676-688.

[4]Apolinario A, Majano PL, Alvarez-Perez E, et al.Increased ex-pression of T cell chemokines and their receptors in chronic hepatitisC:relationship with the histologieal activity of liver disease[J].AmJ Gastroenterol, 2002, 97 (11) :2861-2870.

[5]Harvey CE, Post JJ, Palladinetti P, et al.Expression of the chemo-kine IP-10 (CXCL10) by hepatocytes in chronichepatitis C virusinfection correlates with histological severity and lobularinflammation[J].J Leukoc Biol, 2003, 74 (3) :360-369.

[6] Helbig KJ, Ruszkiewicz A, Semendric L, et al. Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis C and its correlation with hepatic inflammation[J]. Hepatology, 2004, 39 (5) : 1220-1229.

[7]Zeremski M, Dimova R, Brown Q, et al.Peripheral CXCR3-asso-ciated chemokines as biomarkers of fibrosis in chronic hepatitis C vi-rus infection[J].J Infect Dis, 2009, 200 (11) :1774-1780.

[8] Bieche I, Asselah T, Laurendeau I, et al. Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection[J]. Virology, 2005, 332 (1) : 130 -144.

[9] Wang J, Zhao JH, Wang PP, et al. Expression of CXC chemokine IP-10 in patients with chronic hepatitis B[J]. Hepatobiliary Pancreat Dis Int, 2008, 7 (1) : 45-50.

[10]Kessler HH, Preininger S, Stelzl E, et al.Identification of differentstates of hepatitis B virus infection with a quantitative PCR assay[J].Clin Diagn Lab Immunol, 2000, 7 (2) :298-300.

Relative Articles

[1]	Bohua ZHANG, Yan XU, Song ZHANG, Hua HU. Expression of CXCL10 and CXCL12 in gallbladder carcinoma and their mechanism of action in tumor invasion[J]. Journal of Clinical Hepatology, 2024, 40(11): 2260-2265. doi: 10.12449/JCH241120
[2]	Mingwei LI, Jian GAO, Xiangwei ZHAI, Xiangjun QIAN, Xiajie WEN, Mingjie YAO, Zhaojun DUAN, Erjiang ZHAO, Ling ZHANG, Fengmin LU. Construction and analysis of a predictive model for posthepatectomy recurrence in patients with hepatocellular carcinoma based on preoperative CXCL13 measurement[J]. Journal of Clinical Hepatology, 2021, 37(4): 823-828. doi: 10.3969/j.issn.1001-5256.2021.04.020
[3]	Cui HaiXia, Jin ChunMei, Wu ZhengXie, Jin AiHua, Zhang MeiLan. Correlation of miRNA-181c expression in peripheral blood mononuclear cells with interferon-γ,chemokine( C-X-C motif) ligand 10,and Toll-like receptor 4 in children with autoimmune hepatitis[J]. Journal of Clinical Hepatology, 2020, 36(10): 2236-2240. doi: 10.3969/j.issn.1001-5256.2020.10.015
[4]	Zhou Liang, Li XiaoYan, Huang YueHua. Regulatory effect of interleukin-10 on natural killer cells in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2016, 32(8): 1600-1603. doi: 10.3969/j.issn.1001-5256.2016.08.040
[5]	Wang He, Wang QianJun, Sun FengBo, Zhang XinMing, Qi YuQin. Effect of entecavir combined with Fuzheng Huayu capsules on inflammatory factors and fibrosis markers in patients with compensated chronic hepatitis B-related cirrhosis[J]. Journal of Clinical Hepatology, 2016, 32(9): 1734-1738. doi: 10.3969/j.issn.1001-5256.2016.09.020
[6]	Li Yan, Wang Xia, Cheng LiWei, Pan XiuCheng, Dan Ben, Geng Jian, Liu RuiXia, Fu JuanJuan, Li Li. Effects of serum levels of chemokines on sustained virological response in patients with HBeAg-positive chronic hep-atitis B after treatment with pegylated interferon α-2b[J]. Journal of Clinical Hepatology, 2016, 32(3): 467-471. doi: 10.3969/j.issn.1001-5256.2016.03.013
[7]	Dong Jie, Yang XiaoFei, Shen HuanJun, Zhao RongRong, Zhao YanYan, Zhang Ye, Huang ZhangXing, Lian JianQi. Regulatory effect of gamma-chain cytokines on expression of TIM-3 on CD8~+T cells in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2015, 31(2): 205-208. doi: 10.3969/j.issn.1001-5256.2015.02.015
[8]	Wang ShaoYang, Lin TaoFa, Liu HaiZhou, Ma WeiMin, Xie ZhiHong. A clinical study of autologous cytokine-induced killer cells in treatment of patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2015, 31(4): 530-533. doi: 10.3969/j.issn.1001-5256.2015.04.013
[9]	Li Mi, Nie QingHe. Role of CXCL10 in pathogenesis of hepatitis C and antiviral therapy[J]. Journal of Clinical Hepatology, 2015, 31(11): 1820-1824. doi: 10.3969/j.issn.1001-5256.2015.11.013
[10]	Liu LiWei, Li JiaJia, Zhu LiXin, Liu Bo. In vitro proliferation capacity and killing efficacy of CIK cells from umbilical cord blood versus patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2014, 30(9): 873-876. doi: 10.3969/j.issn.1001-5256.2014.09.009
[11]	Liu Bo, Dong Jing, Zhang JunFei, Song HaiYan, Chen CongXin. Efficacy and safety of UCB- derived or autologous CIK cells combined with interferon therapy in patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2014, 30(9): 869-872. doi: 10.3969/j.issn.1001-5256.2014.09.008
[12]	Wu HaiQing, Zhao GangDe, Li FengDi, Liu KeHui, Xu YuMin, Lin LanYi, Xie Qing, Wang Hui. Association between IPS- 1 polymorphisms and PEG- IFN treatment response in patients with HBeAg- positive chronic hepatitis B[J]. Journal of Clinical Hepatology, 2014, 30(8): 757-763. doi: 10.3969/j.issn.1001-5256.2014.08.015
[13]	Guo RuYi, Yu XuePing, Su ZhiJun, Lin ChengZu, Lin ZhiPeng, Lin Qi. Evaluation of telbivudine’s efficacy for treating HBeAg-positive chronic B hepatitis patients and identification of its predictive factors by logistic regression analysis[J]. Journal of Clinical Hepatology, 2013, 29(2): 97-100.
[14]	Ding TiLong, Fan XiuMei, Wang Yong, Huang YiJiang, Ma Yong. Expression of hypoxia-inducible factor-1 α in liver tissues of patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2013, 29(2): 124-127.
[15]	Yang KeLi, Yang Zhan, Fan HuiMin, Hu FengYu, Guan YuJuan, Wu LingJie. Gene copy number variations of BCL2L11 and IL7R in differently progressing patients with chronic HBV infection[J]. Journal of Clinical Hepatology, 2012, 28(6): 431-434.
[16]	Mao XiaoRong, Yue Wei, Zhu Jun, Zhang HaiYun, Xue Miao. The study on relationship of basic fibroblast growth factor with the clinical significance on chronic viral hepatitis B and liver fibrosis[J]. Journal of Clinical Hepatology, 2012, 28(4): 281-284.
[17]	Liu Mei, Zhang LiLi, Chen Ming, Pan XiuCheng, Li Li. The expression of suppressor of cytokine signaling-1 mRNA in the peripheral blood mononuclear cells of patients with chronic hepatitis B infection[J]. Journal of Clinical Hepatology, 2011, 27(5): 500-502.
[18]	Yang Yong, Liu PeiZhi, Zhan AiQin. The assay and significance of CXCL16 in serum of hepatitis B patients.[J]. Journal of Clinical Hepatology, 2008, 24(2): 114-116.
[20]	Shi LiYun, He JianQin, Chen Zhi, Wu LingJiao. The expression and significance of chemokine interferon-inducible protein-10 (IP-10) in chronic hepatitis B patients[J]. Journal of Clinical Hepatology, 2003, 19(4): 220-221.

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (4129) PDF downloads(1536)

The expression and significance of CXCL10 and CXCL11 in chronic hepatitis B patients

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

The expression and significance of CXCL10 and CXCL11 in chronic hepatitis B patients

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content