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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2017
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Article Contents

Value of microRNAs in diagnosis of chronic hepatitis B-related liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2017.12.036
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  • Received Date: 2017-06-21
  • Published Date: 2017-12-20
  • It is very important to find suitable serum markers which can accurately identify chronic hepatitis B ( CHB) -related liver fibrosis. This article summarizes the differentially expressed serum microRNAs ( miRNAs) in the process of CHB-related liver fibrosis. The analysis shows that with the development of liver fibrosis, there are increases in the serum levels of miR-33 a, miR-185, and miR-222 and reductions in the serum levels of miR-122, miR-29, and miR-27 b. It has been found that miRNAs such as miR-185 and miR-122 measured alone or in combination with other indices have a certain clinical value in the diagnosis of CHB-related liver fibrosis. It is pointed out that further research should be conducted for differentially expressed serum miRNAs which have a certain value in the diagnosis of CHB-related liver fibrosis.

     

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