Objective To observe the clinical efficacy of entecavir in the treatment of hepatogenous diabetes (HD) .Methods A retrospective analysis was performed on the clinical data of 72 HD patients, who were divided into treatment group (n=36) and control group (n=36) .Both groups were given diabetic diet and received liver-protecting treatment, symptomatic treatment, and supportive treatment.In addition, the treatment group received oral entecavir (0.5 mg) once daily.The therapeutic effect was assessed after 52 weeks of treatment;the serum hepatitis B virus (HBV) DNA level, liver function (alanine aminotransferase, aspartate aminotransferase, total bilirubin, and albumin) , blood glucose, and glycosylated hemoglobin were measured before and after treatment.The two groups were compared by t test (for measurement data) and chi-square test (for numeration data) .Results After 52 weeks of treatment, 29 (80.56%) of the patients in treatment group had virological response, versus 7 (19.44%) of those in control group (χ2 = 18.00, P<0.01) ;26 (72.22%) of the patients in treatment group had liver function recovery and controlled diabetes, versus 16 (44.44%) of those in control group (χ2=5.774, P<0.05) .The treatment group showed significant improvements in liver function and blood glucose after treatment (P<0.05) ;the treatment group had significantly lower glycosylated hemoglobin and fasting blood glucose than the control group (P<0.01) .Conclusion In the treatment of HBV DNA-positive hepatitis B cirrhosis with HD, entecavir not only can effectively inhibit the replication of viral DNA and promote the recovery of liver function, but also can effectively control HD.
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