中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

Prediction of acute-on-chronic liver failure and integrated traditional Chinese and Western medicine therapy

DOI: 10.3969/j.issn.1001-5256.2020.01.003
Research funding:

 

  • Received Date: 2019-10-08
  • Published Date: 2020-01-20
  • Acute-on-chronic liver failure(ACLF) is a reversible and complex clinical syndrome caused by various factors in patients with pre-existing chronic liver diseases,with the clinical features of acute liver function decompensation and high short-term mortality rate.ACLF has a complex pathogenesis,rapid progression,and a dangerous prognosis,and early and accurate prediction of prognosis is of vital importance. At present,there is still no ideal therapy for ACLF,and in recent years,integrated traditional Chinese and Western medicine therapy has achieved a certain effect in the treatment of this disease. This article reviews the advances in prognostic evaluation and integrated traditional Chinese and Western medicine therapy for ACLF,in order to provide guidance to prognostic evaluation of ACLF and selection of the regimens of integrated traditional Chinese and Western medicine therapy.

     

  • [1] JALAN R,GINES P,OLSON JC,et al. Acute-on-chronic liver failure[J]. J Hepatol,2012,57(6):1336-1348.
    [2] SUN QF,DING JG,XU DZ,et al. Prediction of the prognosis of patients with acute-on-chronic hepatitis B liver failure using the model for end-stage liver disease scoring system and a novel logistic regression model[J]. J Viral Hepat,2009,16(7):464-470.
    [3] KATOONIZADEH A,LALEMAN W,VERSLYPE C,et al. Early features of acute-on-chronic alcoholic liver failure:A prospective cohort study[J]. Gut,2010,59(11):1561-1569.
    [4] WLODZIMIROW KA,ESLAMI S,ABU-HANNA A,et al. A systematic review on prognostic indicators of acute on chronic liver failure and their predictive value for mortality[J]. Liver Int,2013,33(1):40-52.
    [5] OHNISHI H,SUGIHARA J,MORIWAKI H,et al. Acute-onchronic liver failure[J]. Ryoikibetsu Shokogun Shirizu,1995(7):217-219.
    [6] Liver Failure and Aritificall Liver Group,Chinese Society of Infectious Disease,Chinese Medical Association; Sever Liver Disease and Artificial Liver Group,Chinese Society of Hepatology,Chinese Medical Association. Diagnostic and treatment guidelines for liver failure[J]. Inter J Epidemiol Infect Dis,2006,33(4):217-221.(in Chinese)中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学.肝衰竭诊疗指南[J].国际流行病学传染病学杂志,2006,33(4):217-221.
    [7] Liver Failure And Artificiai Liver Group,Chinese Society Of Infectious Diseases,Chinese Medical Association; Severe Liver Disease and Artificial Liver Group,Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure[J]. Chin J Clin Infect Dis,2012,5(6):321-327.(in Chinese)中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南(2012年版)[J].中华临床感染病杂志,2012,5(6):321-327.
    [8] Liver Failure and Artificial Liver Group,Chinese Society of Infectious Diseases,Chinese Medical Association; Severe Liver Disease and Artificial Liver Group,Chinese Society of Hepatology,Chinese Medical Association. Guideline for diagnosis and treatment of liver failure(2018)[J]. J Clin Hepatol,2019,35(1):38-44.(in Chinese)中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南(2018年版)[J].临床肝胆病杂志,2019,35(1):38-44.
    [9] VINCENT JL,MORENO R,TAKALA J,et al. The SOFA(Sepsis-related Organ Failure Assessment)score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine[J]. Intensive Care Med,1996,22(7):707-710.
    [10] AGRAWAL S,DUSEJA A,GUPTA T,et al. Simple organ failure count versus CANONIC grading system for predicting mortality in acute-on-chronic liver failure[J]. J Gastroenterol Hepatol,2015,30(3):575-581.
    [11] MOREAU R,JALAN R,GINES P,et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis[J]. Gastroenterology,2013,144(7):1426-1437.
    [12] SY E,RONCO JJ,SEARLE R,et al. Prognostication of critically ill patients with acute-on-chronic liver failure using the Chronic Liver Failure-Sequential Organ Failure Assessment:A Canadian retrospective study[J]. J Crit Care,2016,36:234-239.
    [13] JALAN R,SALIBA F,PAVESI M,et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure[J]. J Hepatol,2014,61(5):1038-1047.
    [14] HERNAEZ R,SOLE,MOREAU R,et al. Acute-on-chronic liver failure:An update[J]. Gut,2017,66(3):541-553.
    [15] MCKE MM,RMYANTSEVA T,MUCKE VT,et al. Bacterial infection-triggered acute-on-chronic liver failure is associated with increased mortality[J]. Liver Int,2018,38(4):645-653.
    [16] LI H,CHEN LY,ZHANG NN,et al. Characteristics,diagnosis and prognosis of acute-on-chronic liver failure in cirrhosis associated to hepatitis B[J]. Sci Rep,2016,6:25487.
    [17] CHOUDHURY A,JINDAL A,MAIWALL R,et al. Liver failure determines the outcome in patients of acute-on-chronic liver failure(ACLF):Comparison of APASL ACLF research consortium(AARC)and CLIF-SOFA models[J]. Hepatol Int,2017,11(5):461-471.
    [18] SARIN SK,CHOUDHURY A,SHARMA MK,et al. Acute-on-chronic liver failure:Consensus recommendations of the Asian Pacific association for the study of the liver(APASL):An update[J]. Hepatol Int,2019,13(4):353-390.
    [19] WU T,LI J,SHAO L,et al. Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure[J]. Gut,2018,67(12):2181-2191.
    [20] GAO F,ZHANG Q,LIU Y,et al. Nomogram prediction of individual prognosis of patients with acute-on-chronic hepatitis B liver failure[J]. Dig Liver Dis,2019,51(3):425-433.
    [21] BASS DA,PARCE JW,DECHATELET LR,et al. Flow cyto metric studies of oxidative product formation by neutrophils:A graded response to membrane stimulation[J]. J Immunol,1983,130(4):1910-1917.
    [22] ZAHOREC R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill[J]. Bratisl Lek Listy,2001,102(1):5-14.
    [23] LIU H,ZHANG H,WAN G,et al. Neutrophil-lymphocyte ratio:A novel predictor for short-term prognosis in acute-onchronic hepatitis B liver failure[J]. J Viral Hepat,2014,21(7):499-507.
    [24] KWON JH,JANG JW,KIM YW,et al. The usefulness of Creactive protein and neutrophil-to-lymphocyte ratio for predicting the outcome in hospitalized patients with liver cirrhosis[J]. BMC Gastroenterol,2015,15:146.
    [25] MIYAMOTO M,PRAUSE O,SJSTRAND M,et al. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways[J]. J Immunol,2003,170(9):4665-4672.
    [26] LIU HM,FENG ZJ. Early prognostic evaluation of biomarkers for acute-on-chronic liver failure[J]. Clin Focus,2018,33(11):933-937.(in Chinese)刘慧敏,冯志杰.生物学标志物对慢加急性肝衰竭早期预后的评估[J].临床荟萃,2018,33(11):933-937.
    [27] SUN Z,LIU X,WU D,et al. Circulating proteomic panels for diagnosis and risk stratification of acute-on-chronic liver failure in patients with viral hepatitis B[J]. Theranostics,2019,9(4):1200-1214.
    [28] GAO FY,LIU Y,LI XS,et al. Score model for predicting acute-on-chronic liver failure risk in chronic hepatitis B[J]. World J Gastroenterol,2015,21(27):8373-8381.
    [29] ZHOU C,GONG M,ZHANG N,et al. Study on the intervention of integrated traditional Chinese and Western medicine therapy in patients with hepatitis B virus-related acute-onchronic liver failure[J]. Chin J Integr Tradit West Med Liver Dis,2019,29(3):203-207.(in Chinese)周超,宫嫚,张宁,等.中西医结合治疗方案干预乙型肝炎病毒相关慢加急性肝衰竭的疗效分析[J].中西医结合肝病杂志,2019,29(3):203-207.
    [30] China Association Of Chinese Medicine. Guidelines for clinical diagnosis and treatment of acute-on-chronic liver failure in traditional Chinese medicine[J]. J Clin Hepatol,2019,35(3):494-503.(in Chinese)中华中医药学会.慢加急性肝衰竭中医临床诊疗指南[J].临床肝胆病杂志,2019,35(3):494-503.
    [31] Infectious Disease Committee,China Society of Integrated Traditional Chinese and Western Medicine; Liver Disease Committee,China Society of Integrated Traditional Chinese and Western Medicine; Branch of Hepatobiliary Diseases,China Association of Chinese Medicine. Recommendations for integrated traditional Chinese and Western medicine diagnosis and treatment of HBVrelated acute-on chronic liver failure[J]. J Clin Hepatol,2019,35(6):1215-1221.(in Chinese)中国中西医结合学会传染病专业委员会,中国中西医结合学会肝病专业委员会,中华中医药学会肝胆病分会.HBV相关慢加急性肝衰竭中西医结合诊疗推荐意见[J].临床肝胆病杂志,2019,35(6):1215-1221.
    [32] LIU HM,GAO FY,JIANG YY,et al. Clinical observation on 30cases of hepatitis B at early stage of acute-on-chronic liver failure treated by Modified Jiedu Liangxue Lishi Fang combined with Western medicine[J]. J Tradit Chin Med,2018,59(1):41-45.(in Chinese)刘慧敏,高方媛,江宇泳,等.解毒凉血利湿方加减联合西药治疗乙型肝炎慢加急性肝衰竭前期30例临床观察[J].中医杂志,2018,59(1):41-45.
    [33] LIU HM,GAO FY,YU H,et al. Analysis of the method of detoxification and cooling blood and invigorating spleen to treat HBV-related acute-on-chronic liver[J]. China J Tradit Chin Med Pharma,2017,32(2):440-442.(in Chinese)刘慧敏,高方媛,于浩,等.解毒凉血健脾法治疗乙型肝炎慢加急性肝功能衰竭理论探析[J].中华中医药杂志,2017,32(2):440-442.
    [34] WANG XB,LI B,LIU HM. Experience in detoxicating,bloodcooling,spleen-strenghening,and dampness-removing therapy for hepatitis B-related acute-on-chronic liver failure[J]. J Tradit Chin Med,2012,53(20):1772-1776.(in Chinese)王宪波,李斌,刘慧敏.解毒凉血、健脾化湿法治疗乙型肝炎慢加急性肝功能衰竭体会[J].中医杂志,2012,53(20):1772-1776.
    [35] LIU HM,WANG XB,WANG RB. Short term efficacy of integrated traditional Chinese and western medicine therapy based on cooling blood and detoxification methods to treat acute-on-chronic hepatitis B liver failure[J]. Chin J Integr Tradit West Med Liver Dis,2011,21(4):197-200.(in Chinese)刘慧敏,王宪波,王融冰.基于解毒凉血法的中西医结合方案治疗乙型肝炎慢加急性肝衰竭疗效分析[J].中西医结合肝病杂志,2011,21(4):197-200.
    [36] LIU HM,WANG XB,HOU YX,et al. Efficacy and safety of integrative medical program based on blood cooling and detoxification recipein treaing patients with hepatitis B virus related acute-on-chronic liver failure:A randomized controlled clinical study[J]. Chin J Integr Trad West Med,2014,34(4):412-417.(in Chinese)刘慧敏,王宪波,侯艺鑫,等.解毒凉血方加减治疗乙型肝炎慢加急性肝衰竭的随机对照临床研究[J].中国中西医结合杂志,2014,34(4):412-417.
    [37] QIAN Y. Severance and reversion therapy for severe chronic hepatitis[J]. Beijing J Tradit Chin Med,2008,27(2):85-87.(in Chinese)钱英.截断逆挽法治疗慢性重型肝炎[J].北京中医药,2008,27(2):85-87.
    [38] HU JH,QIN Y,YAO NL,et al. Treatment of chronic severe hepatitis B by Jieduan Niwan method[J]. Chin J Integr Tradit West Med Liver Dis,2010,20(4):200-203.(in Chinese)胡建华,钱英,姚乃礼,等.“截断逆挽法”治疗慢性乙型重型肝炎临床疗效观察[J].中西医结合肝病杂志,2010,20(4):200-203.
    [39] ZHOU ZE,LU P,HAN L,et al. A multi-center randomized parallel-controlled clinical study on efficiency of rhubarb decoction retention enema combined with Western medicine in treating hepatic encephalopathy[J]. Liaoning J Tradit Chin Med,2014,41(9):1918-1921.(in Chinese)周智恩,卢萍,韩丽,等.大黄煎剂保留灌肠联合西药治疗肝性脑病多中心随机平行对照研究[J].辽宁中医杂志,2014,41(9):1918-1921.
    [40] HUANG GY,MAO DW,LONG FL,et al. Retention enema with rhubarb decoction in treating hepatic encephalopathy:Results from a Multi-center clinical trial[J]. Liaoning J Tradit Chin Med,2011,38(7):1364-1366.(in Chinese)黄古叶,毛德文,龙富立,等.大黄煎剂保留灌肠治疗肝性脑病的多中心临床研究[J].辽宁中医杂志,2011,38(7):1364-1366.
    [41] LIU YJ,TAN LX,MA XW. Clinical efficacy of intestinal infusion of Jiaohuang decoction in treating early-and middle-stage chronic severe hepatitis B:A report of 59 cases[J]. Hunan J Tradit Chin Med,2014,30(9):15-17.(in Chinese)刘益军,谭兰香,马新文.角黄汤肠道滴入治疗早中期慢性乙型重型肝炎59例疗效观察[J].湖南中医杂志,2014,30(9):15-17.
    [42] HAN ZY. Effect of detoxicating and stasis-resolving therapy on endotoxin level in patients with acute-on-chronic liver failure and related mechanism[D]. Guangzhou:Guangzhou University of Chinese Medicine,2017.(in Chinese)韩志毅.解毒化瘀法对慢加急性肝衰竭内毒素水平的影响及机制研究[D].广州:广州中医药大学,2017.
    [43] LIAN YN. Association between peripheral blood T cell frequency and prognosis in HBV-ACLF patients and the immunological mechanism of Qi-tonifying and spleen-strengthening therapy in improving prognosis[D]. Nanjing:Nanjing University of Chinese Medicine,2016.(in Chinese)廉亚男.HBV-ACLF患者外周血T淋巴细胞频数与预后的相关性及益气健脾法改善预后的免疫学机制[D].南京:南京中医药大学,2016.
    [44] LI MM. Effect of Jianpi Qinghua prescription on T lymphocytes and related cytokines in vitro in patients with acute-on-chronic liver failure[D]. Zhengzhou:Henan University of Chinese Medicine,2016.(in Chinese)李明明.健脾清化方对慢加急性肝衰竭患者体外T淋巴细胞及其细胞因子的影响[D].郑州:河南中医药大学,2016.
    [45] SHI QL,MAO DW,ZHANG RZ,et al. Effect of Jiedu Huayu granules on peripheral blood T lymphocyte subsets in patients with chronic liver failure[J]. J Guangxi Univ Chin Med,2013,16(2):28-30.(in Chinese)石清兰,毛德文,张荣臻,等.解毒化瘀颗粒对慢性肝衰竭患者外周血T细胞亚群的影响[J].广西中医药大学学报,2013,16(2):28-30.
    [46] CUI LJ,DANG ZF,ZHANG QY,et al. Effects of the Prescription of Truncation and Inverse Draft on the TNF-α,IL-1βand IL-6 of serum in acute-on-chronic liver failure model rats[J]. Guid J Tradit Chin Med Pharm,2013,19(1):8-11.(in Chinese)崔利娟,党泽方,张秋云,等.截断逆挽方对慢加急性肝衰竭大鼠血清TNF-α、IL-1β及IL-6的影响[J].中医药导报,2013,19(1):8-11.
    [47] LIU Y,MAO DW,WANG MG,et al. Effect of Jiedu Huayu granules on gut microbiota and intestinal barrier function in patients with acute-on-chronic liver failure[J]. Lishizhen Med Mater Med Res,2018,29(12):2841-2843.(in Chinese)刘茵,毛德文,王明刚,等.解毒化瘀颗粒对慢加急性肝衰竭患者肠道菌群及肠道屏障功能的影响[J].时珍国医国药,2018,29(12):2841-2843.
    [48] HE W,CHEN B,XU JW,et al. Effect of “Ganbing Shipi”method on endotoxemia in ACLF rats[J]. J Tradit Chin Med Univ Hunan,2015,35(3):12-15.(in Chinese)何琬,陈斌,徐嘉蔚,等.“肝病实脾”法对ACLF大鼠内毒素血症的影响[J].湖南中医药大学学报,2015,35(3):12-15.
    [49] ZHAO YJ. Research advances in the application of traditional Chinese medicine enema in treatment of liver failure[J]. Nei Mongol J Tradit Chin Med,2018,37(7):120-121.(in Chinese)赵云洁.中药灌肠在肝衰竭治疗中的应用研究进展[J].内蒙古中医药,2018,37(7):120-121.
    [50] LIU HM. Clinical effect of detoxicating and blood-cooling therapy in treatment of hepatitis B-related acute-on-chronic liver failure and related mechanism[D]. Beijing:Beijing University of Chinese Medicine,2013.(in Chinese)刘慧敏.解毒凉血法治疗乙型肝炎慢加急性肝衰竭的疗效评价及机制研究[D].北京:北京中医药大学,2013.
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