Mechanism of action and potential value of the IRE1α/TRAF2/JNK pathway in the progression of acute liver failure

Haimei GUAN; Kan ZHANG; Weiyu CHEN; Guobao LI; Yangling ZENG; Riyun ZHANG; Tianwen WANG; Baohua XIE; Dewen MAO

doi:10.12449/JCH240633

Volume 40 Issue 6

Jun. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(6): 1281-1288

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Mechanism of action and potential value of the IRE1α/TRAF2/JNK pathway in the progression of acute liver failure

DOI: 10.12449/JCH240633

1.
Graduate School，Guangxi University of Chinese Medicine，Nanning 530001，China
2.
Department of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

National Natural Science Foundation of China (82274434);

National Natural Science Foundation of China (81960841);

National Natural Science Foundation of China (82060848);

Guangxi University of Traditional Chinese Medicine Graduate Education Innovation Program (YCBZ2023157)

More Information

Corresponding author: MAO Dewen， mdwboshi2005@163.com （ORCID： 0000-0001-9438-9325）
Received Date: 2023-11-15
Accepted Date: 2024-01-18
Published Date: 2024-06-25

Abstract

Abstract

Acute liver failure （ALF） is one of the most critical liver diseases in clinical practice and seriously affects the life and health of Chinese people. Due to its high morbidity and mortality rates， unclear pathogenesis， and limited treatment methods， ALF has become a major problem that needs to be solved urgently in the field of liver diseases. In recent years， more and more studies have shown that endoplasmic reticulum stress is a key biological process in the progression of ALF， and the IRE1α/TRAF2/JNK pathway， as a part of endoplasmic reticulum stress signaling， plays a role in amplifying inflammatory response， promoting hepatocyte apoptosis， and inhibiting liver regeneration ability during the progression of diseases. As a traditional treasure of China， traditional Chinese medicine has become a research hotspot in search for effective prevention and treatment drugs for ALF from monomers of Chinese herbs. This article elaborates on the mechanism of action of the IRE1α/TRAF2/JNK pathway in the progression of ALF and summarizes the potential value of several monomers of Chinese herbs in regulating this pathway， such as salidroside， Fructus Broussonetiae， Fructus Psoraleae+Schisandra chinensis， baicalein， genipin， kaempferol， resveratrol， sea buckthorn polysaccharide extract， and luteol， in order to provide a reference for further research and clinical practice of ALF.
- Liver Failure， Acute,
- Signal Transduction,
- Endoplasmic Reticulum Stress

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References

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Mechanism of action and potential value of the IRE1α/TRAF2/JNK pathway in the progression of acute liver failure

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Mechanism of action and potential value of the IRE1α/TRAF2/JNK pathway in the progression of acute liver failure

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