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ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 1
Jan.  2014
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Article Navigation >  Journal of Clinical Hepatology  > 2014  >  30(1): 18-22

Prognos is of living donor liver transplantation performed during different periods in infants with biliary atresia: a single- center experience with 101 cases

DOI: 10.3969/j.issn.1001-5256.2014.01.006

  • Department of Liver Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine

Research funding:

 

  • Received Date: 2013-10-13
  • Published Date: 2014-01-20
    Abstract

  • Objective To compared the prognosis between infants with biliary atresia ( BA) who underwent living donor liver transplantation ( LDLT) during 2006- 2009 and 2010- 2012 in the Department of Liver Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine and to evaluate the prognos is of LDLT performed during different periods. Methods A retrospective analysis was performed on the clinical data of 101 infants with BA who underwent LDLT from October 2006 to December 2012. These patients were divided into 2006- 2009 group and 2010- 2012 group according to the year the procedure was performed. The two groups were compared in terms of preoperative general data, intraoperative status, and treatment outcome. The Kaplan- Meier method was used for survival analysis; measurement data were analyzed by t test, and enumeration data were analyzed by Fisher exact probability test and chi- square test. Results The preoperative general data showed no significant difference between the two groups. Compared with the 2006- 2009 group, the 2010- 2012 group had significantly less intraoperative blood loss ( t = 2. 05, P = 0. 04) , a significantly shorter cold ischemia time of donor liver ( t = 3. 25, P < 0. 01) , and significantly lower incidence of postoperative biliary complications ( χ2= 4. 27, P = 0. 04) , pulmonary infection ( χ2= 4. 47, P = 0. 03) , and acute rejection ( P = 0. 03) . The 2010- 2012 group had significantly improved survival compared with the 2006- 2009 group; the 1 and 2 year cumulative survival rates for the 2010- 2012 group were 88. 4% and 88. 4%, respectively, versus 84. 4% and 75% for the 2006- 2009 group. Conclusion The development of surgical techniques, improvement in perioperative management, and standardized follow- up can significantly increase the success rate of surgery and survival rate and reduce postoperative complications in BA patients.

     

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