Prognos is of living donor liver transplantation performed during different periods in infants with biliary atresia: a single- center experience with 101 cases

Hua XiangWei; Xia Qiang; Zhang JianJun; Li QiGen; Xu Ning; Chen XiaoSong; Zhang Ming; Xue Feng; Han LongZhi; Wang Xin; Xia Lei; Luo Yi; Shen CongHuan; Xing TianYu; Xi ZhiFeng

doi:10.3969/j.issn.1001-5256.2014.01.006

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Jan. 2014

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Prognos is of living donor liver transplantation performed during different periods in infants with biliary atresia: a single- center experience with 101 cases

DOI: 10.3969/j.issn.1001-5256.2014.01.006

Department of Liver Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine

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Received Date: 2013-10-13
Published Date: 2014-01-20

Abstract

Abstract

Objective To compared the prognosis between infants with biliary atresia ( BA) who underwent living donor liver transplantation ( LDLT) during 2006- 2009 and 2010- 2012 in the Department of Liver Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine and to evaluate the prognos is of LDLT performed during different periods. Methods A retrospective analysis was performed on the clinical data of 101 infants with BA who underwent LDLT from October 2006 to December 2012. These patients were divided into 2006- 2009 group and 2010- 2012 group according to the year the procedure was performed. The two groups were compared in terms of preoperative general data, intraoperative status, and treatment outcome. The Kaplan- Meier method was used for survival analysis; measurement data were analyzed by t test, and enumeration data were analyzed by Fisher exact probability test and chi- square test. Results The preoperative general data showed no significant difference between the two groups. Compared with the 2006- 2009 group, the 2010- 2012 group had significantly less intraoperative blood loss ( t = 2. 05, P = 0. 04) , a significantly shorter cold ischemia time of donor liver ( t = 3. 25, P < 0. 01) , and significantly lower incidence of postoperative biliary complications ( χ2= 4. 27, P = 0. 04) , pulmonary infection ( χ2= 4. 47, P = 0. 03) , and acute rejection ( P = 0. 03) . The 2010- 2012 group had significantly improved survival compared with the 2006- 2009 group; the 1 and 2 year cumulative survival rates for the 2010- 2012 group were 88. 4% and 88. 4%, respectively, versus 84. 4% and 75% for the 2006- 2009 group. Conclusion The development of surgical techniques, improvement in perioperative management, and standardized follow- up can significantly increase the success rate of surgery and survival rate and reduce postoperative complications in BA patients.
- biliary atresia,
- liver transplantation,
- infant,
- prognosis

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[1]BRINDLEY SM, LANHAM AM, KARRER FM, et al.Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells[J].Hepatology, 2012, 55 (4) :1130-1138.

[2]CUI S, LEYVA-VEGA M, TSAI EA, et al.Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene[J].Gastroenterology, 2013, 144 (5) :1107-1115, e1103.

[3]CHEN CL, CONCEJERO A, WANG CC, et al.Living donor liver transplantation for biliary atresia:a single-center experience with first 100 cases[J].Am J Transplant, 2006, 6 (11) :2672-2679.

[4]XIA Q, LI QG.Surgical treatment of congenital atresia of biliary duct[J].J Clin Surg, 2007, 15 (4) :222-223. (in Chinese) 夏强, 李齐根.先天性胆道闭锁的外科治疗[J].临床外科杂志, 2007, 15 (4) :222-223.

[5]GOSS JA, SHACKLETON CR, MCDIARMID SV, et al.Longterm results of pediatric liver transplantation:an analysis of 569transplants[J].Ann Surg, 1998, 228 (3) :411-420.

[6]FARMER DG, VENICK RS, MCDIARMID SV, et al.Predictors of outcomes after pediatric liver transplantation:an analysis of more than 800 cases performed at a single institution[J].J Am Coll Surg, 2007, 204 (5) :904-916.

[7]ZHU JJ, XIA Q, ZHANG JJ, et al.Forty-four living donor liver transplantations for children with biliary atresia[J].Chin J Organ Transplant, 2011, 32 (7) :415-418. (in Chinese) 朱建军, 夏强, 张建军, 等.活体肝移植治疗儿童胆道闭锁44例[J].中华器官移植杂志, 2011, 32 (7) :415-418.

[8]TANG XY, XIA Q, ZHANG JJ, et al.Application of immunosuppressive agents in children with pediatric living-donor liver transplantation[J].Chin J Organ Transplant, 2012, 33 (5) :283-286. (in Chinese) 汤晓寅, 夏强, 张建军, 等.小儿活体肝移植后免疫抑制剂的应用体会[J].中华器官移植杂志, 2012, 33 (5) :283-286.

[9]RAIA S, NERY JR, MILES S.Liver transplantation from live donors[J].Lancet, 1989, 2 (8661) :497.

[10]MCDIARMID SV, ANAND R, LINDBLAD AS.Studies of Pediatric Liver Transplantation:2002 update.An overview of demographics, indications, timing, and immunosuppressive practices in pediatric liver transplantation in the United States and Canada[J].Pediatr Transplant, 2004, 8 (3) :284-294.

[11]OHI R, MOCHIZUKI I, KOMATSU K, et al.Portal hypertension after successful hepatic portoenterostomy in biliary atresia[J].J Pediatr Surg, 1986, 21 (3) :271-274.

[12]OTTE JB, de VILLE de GOYET J, REDING R, et al.Sequential treatment of biliary atresia with Kasai portoenterostomy and liver transplantation:a review[J].Hepatology, 1994, 20 (1 Pt 2) :s41-s48.

[13]MAHADEB P, GRAS J, SOKAL E, et al.Liver transplantation in children with fulminant hepatic failure:The UCL experience[J].Pediatr Transplant, 2009, 13 (4) :414-420.

[14]LEE KW, CAMERON AM, MALEY WR, et al.Factors affecting graft survival after adult/child split-liver transplantation:analysis of the UNOS/OPTN data base[J].Am J Transplant, 2008, 8 (6) :1186-1196.

[15]BOURDEAUX C, TRI TT, GRAS J, et al.PELD score and posttransplant outcome in pediatric liver transplantation:a retrospective study of 100 recipients[J].Transplantation, 2005, 79 (9) :1273-1276.

[16]MCDIARMID SV, ANAND R, MARTZ K, et al.A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation[J].Ann Surg, 2011, 254 (1) :145-154.

[17]EVRARD V, OTTE JB, SOKAL E, et al.Impact of surgical and immunological parameters in pediatric liver transplantation:a multivariate analysis in 500 consecutive recipients of primary grafts[J].Ann Surg, 2004, 239 (2) :272-280.

[18]XIA Q, ZHANG JJ, LI QG, et al.Pediatric living donor liver transplantation:a report of 33 cases[J].Chin J Dig Surg, 2011, 10 (1) :40-43. (in Chinese) 夏强, 张建军, 李齐根, 等.婴幼儿活体肝移植33例[J].中华消化外科杂志, 2011, 10 (1) :40-43.

[19]TAKAHASHI Y, NISHIMOTO Y, MATSUURA T, et al.Surgical complications after living donor liver transplantation in patients with biliary atresia:a relatively high incidence of portal vein complications[J].Pediatr Surg Int, 2009, 25 (9) :745-751.

[20]MIZUTA K, SANADA Y, WAKIYA T, et al.Living-donor liver transplantation in 126 patients with biliary atresia:single-center experience[J].Transplant Proc, 2010, 42 (10) :4127-4131.

[21]WOJCICKI M, MILKIEWICZ P, SILVA M.Biliary tract complications after liver transplantation:a review[J].Dig Surg, 2008, 25 (4) :245-257.

[22]OH SH, KIM KM, KIM DY, et al.Long-term outcomes of pediatric living donor liver transplantation at a single institution[J].Pediatr Transplant, 2010, 14 (7) :870-878.

[23]AALAMI OO, ALLEN DB, ORGAN CH JR.Chylous ascites:a collective review[J].Surgery, 2000, 128 (5) :761-778.

[24]MARTIN SR, ATKISON P, ANAND R, et al.Studies of Pediatric Liver Transplantation 2002:patient and graft survival and rejection in pediatric recipients of a first liver transplant in the United States and Canada[J].Pediatr Transplant, 2004, 8 (3) :273-283.

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Prognos is of living donor liver transplantation performed during different periods in infants with biliary atresia: a single- center experience with 101 cases

DOI: 10.3969/j.issn.1001-5256.2014.01.006

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Prognos is of living donor liver transplantation performed during different periods in infants with biliary atresia: a single- center experience with 101 cases

DOI: 10.3969/j.issn.1001-5256.2014.01.006

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