Clinical features of non- B non- C hepatocellular carcinoma and virus-associated hepatocellular carcinoma and re-lated prognostic factors

Objective To investigate the differences in the clinical features of non- B,non- C hepatocellular carcinoma( NBNC- HCC)and virus- associated hepatocellular carcinoma( BC- HCC) and related prognostic factors. Methods A total of 231 patients with primary liver cancer who underwent partial hepatectomy in Guangzhou First People's Hospital from January 1,1999 to July 1,2014 were selected,and those who were lost to follow- up and unwilling to cooperate were excluded; 146 patients were finally enrolled,and were divided into NBNC- HCC group( 35 patients) and BC- HCC group( 111 patients). The patients' clinical data were collected,and the patients were followed up to record their survival,time to recurrence,and death time. The chi- square test was applied for comparison of categorical data between groups,and the t- test was applied for comparison of continuous data between groups. The log- rank test was applied for comparison of survival rates,the Kaplan- Meier method was applied for univariate analysis and survival analysis,and the Cox proportional hazards regression model was applied for multivariate analysis. Results Compared with the BC- HCC group,the NBNC- HCC group had a significantly higher mean age and a significantly higher proportion of patients in TNM stage Ⅰ- Ⅱ( t = 3. 878,P < 0. 05; χ2= 4. 357,P < 0. 05),as well as a significantly lower preoperative level of alpha- fetoprotein( AFP)( t = 7. 848,P < 0. 05). The mean survival time for the NBNC- HCC group and the BC- HCC group was 35. 5 ± 27. 9 months and 26. 8 ± 21. 7 months,respectively,and there were significant differences in the 3- and 5- year survival rates between the NBNC- HCC group and the BC- HCC group( 61. 6% vs 26. 6%,39. 2% vs14. 1%,both P < 0. 05). Multivariate analysis showed that albumin( Alb) level was the independent prognostic factor for the NBNC- HCC group( RR = 0. 919,95% CI: 0. 851- 0. 994; P = 0. 036); the diameter of tumor was the independent prognostic factor for the BC- HCC group( RR = 1. 082,95% CI: 1. 027- 1. 141; P = 0. 003). Conclusion NBNC- HCC and BC- HCC have differences in age,AFP level,and TNM stage. Alb level is the independent prognostic factor for NBNC- HCC,and the diameter of tumor is the independent prognostic factor for BCV- HCC.