Liver failure is one of the most serious complications after liver cancer resection. Hemodynamic changes, bile salt imbalance, and impaired immune function can cause liver failure after liver cancer resection, and related risk factors include patient, liver, and surgical conditions. This article summarizes the causes and influencing factors for liver failure after liver cancer resection and points out that prophylactic measures before surgery, expansion of remnant liver volume, adjustment of hemodynamic imbalance of the liver, and optimization of perioperative treatment help to reduce the incidence rate of liver failure after liver cancer resection and improve the prognosis and long-term survival of such patients.
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