Effect of hemihepatic vascular exclusion versus total hepatic vascular exclusion in hepatectomy for primary liver cancer: A Meta-analysis

Ying LIU; Benjian GAO; Xiaoli YANG; Cheng FANG; Song SU; Bo LI

doi:10.3969/j.issn.1001-5256.2021.01.015

Volume 37 Issue 1

Jan. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(1): 73-78

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Effect of hemihepatic vascular exclusion versus total hepatic vascular exclusion in hepatectomy for primary liver cancer: A Meta-analysis

DOI: 10.3969/j.issn.1001-5256.2021.01.015

Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University; Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan 646000, China

Received Date: 2020-08-06
Accepted Date: 2020-08-21
Published Date: 2021-01-20

Abstract

Abstract

Objective To systematically evaluate the effect of Pringle's measure (PM) versus hemihepatic vascular occlusion (HVO) in hepatectomy for primary liver cancer. Methods Related Chinese and English databases were searched for control studies on HVI versus PM in the treatment of primary liver cancer published up to June 2020. After quality evaluation and data extraction of the included studies, RevMan5.3 software was used for the meta-analysis. Results A total of 10 studies were included in the Meta-analysis, with 1272 patients in total. On days 1 and 3 after surgery, the HVO group had a significantly lower level of alanine aminotransferase than the PM group (day 1: mean difference [MD]=-172.71, 95% confidence interval [CI]: -289.26 to -56.16, P=0.004; day 3: MD=-130.35, 95%CI: -221.25 to -39.45, P=0.005). On day 3 after surgery, the HVO group had a significantly lower level of aspartate aminotransferase than the PM group (MD=-84.56, 95%CI: -166.47 to -2.65, P=0.04), and on days 1 and 3 after surgery, the HVO group had a significantly higher level of albumin than the PM group (day 1: MD=1.31, 95%CI: 0.06-2.56, P=0.04; day 3: MD=1.81, 95%CI: 0.27-3.35, P=0.02). The HVO group had a significantly longer time of operation than the PM group (MD=8.95, 95%CI: 4.30-13.60, P < 0.01). Conclusion HVO is a safe and effective method for vascular occlusion, and compared with PM, it can effectively alleviate liver injury. However, surgeons should select a suitable method for occlusion based on their own personal experience, patients' conditions, and specific situation during surgery.
- Liver Neoplasms,
- Therapeutic Occlusion,
- Hepatectomy,
- Meta-Analysis as Topic

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Effect of hemihepatic vascular exclusion versus total hepatic vascular exclusion in hepatectomy for primary liver cancer: A Meta-analysis

DOI: 10.3969/j.issn.1001-5256.2021.01.015

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