Association of blood lipids and albumin-bilirubin index with disease progression in patients with chronic hepatitis B virus infection

Objective To investigate the value of blood lipid indices and albumin-bilirubin index ( ALBI) in evaluating the progression ofchronic hepatitis B virus ( HBV) infection. Methods A total of 184 patients with chronic HBV infection who visited The Second AffiliatedHospital of Anhui Medical University from June 2016 to June 2017 were enrolled, and according to the stage of the disease, they were divid-ed into ASC group ( 74 HBV carriers) , CHB group ( 70 patients with chronic hepatitis B) , and LC group ( 40 patients with compensated cir-rhosis) . A total of 50 healthy individuals were enrolled as health control ( HC) group. Blood lipid indices and liver function parameters weremeasured, and the changes in blood lipid indices and ALBI during the progression of chronic HBV infection were analyzed. A one-way a-nalysis of variance was used for comparison of continuous data between multiple groups, and the Dunnett method was used for further compar-ison between two groups; the chi-square test was used for comparison of categorical data between groups; Pearson correlation analysis wasused to investigate correlation. Results There were significant differences between the ASC, CHB, LC, and HC groups in blood lipid indi-ces of cholesterol ( CHO) , high-density lipoprotein cholesterol ( HDL-C) , low-density lipoprotein cholesterol ( LDL-C) , apolipopro-tein A ( APOA) , and apolipoprotein B ( F = 12. 075, 19. 559, 6. 554, 9. 392, and 5. 458, all P < 0. 001) , and the LC group had signifi-cantly greater reductions in the above indices compared with the other three groups ( all P < 0. 05) . There was a significant difference in AL-BI between the four groups ( F = 49. 225, P < 0. 001) ; the LC group had a significantly higher ALBI than the other three groups ( all P <0. 05) , and the ASC and CHB groups had a significantly higher ALBI than the HC group ( both P < 0. 05) . CHO, HDL-C, LDL-C, andAPOA were negatively correlated with ALBI ( all P < 0. 05) , among which CHO and HDL-C had the strongest correlation with ALBI ( r =-0. 310 and-0. 266, both P < 0. 001) . Conclusion In patients with chronic HBV infection, blood lipid indices and ALBI can reflectthe degree of liver function damage, especially in patients with liver cirrhosis.