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Aug.  2011
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Article Navigation >  Journal of Clinical Hepatology  > 2011  >  27(8): 881-884

Hepatitis B virus infection and DNA methylation in hepatocellular carcinoma

  • Published Date: 2011-08-20
    Abstract
  • The persistent and chronic HBV infection is a main risk factor of hepatocarcinogenesis.The recent studies reported that epigenetics, especially the hypermethylation of CpG islands of the tumor suppressor gene, played an important role in hepatocarcinogenesis, and epigenetic changes appeared in the early stage of tumor formation.Methylation in HCC occured in a gene-specific and cancer-specific manner.It may be benefit to the early diagnosis and prognosis assessment.Here we review current opinions about hypermethylation of tumor suppressor gene induced by HBV infection.

     

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    • References(22)
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