Mechanism of action of Fuzheng Huayu prescription in treatment of liver cancer based on network pharmacology

Jingshu QI; Dabing PING; Xin SUN; Jingbo XUE; Yanyan TAO; Yuan PENG; Chenghai LIU

doi:10.3969/j.issn.1001-5256.2021.10.016

Volume 37 Issue 10

Oct. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(10): 2338-2342

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Mechanism of action of Fuzheng Huayu prescription in treatment of liver cancer based on network pharmacology

DOI: 10.3969/j.issn.1001-5256.2021.10.016

Jingshu QI¹,
Dabing PING¹,
Xin SUN²,
Jingbo XUE¹,
Yanyan TAO¹,
Yuan PENG^{1
,
,},
Chenghai LIU^{1, 2, 3, 4
,
,}

1.
Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2.
Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China
3.
Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai 201203, China
4.
Shanghai Innovation Center of TCM Health Service, Shanghai 201203, China

Research funding:

National Natural Science Foundation of China (81730109);

National Natural Science Foundation of China (81874363);

National Science and Technology Major Project during the 13th Five-Year Plan Period (2018ZX10302204);

Shanghai Key Specialty of Traditional Chinese Clinical Medicine (shslczdzk01201)

Received Date: 2021-02-09
Accepted Date: 2021-03-17
Published Date: 2021-10-20

Abstract

Abstract

Objective To investigate the mechanism of Fuzheng Huayu(FZHY) decoction in the treatment of liver cancer based on network pharmacology. Methods TCMSP, BATMAN, and Drugbank databases were searched for the main chemical components and corresponding targets of FZHY, and STRING database was used to perform a PPI network analysis. Cytoscape software was used to establish a drug-disease network model and perform a network analysis, and R language was used to perform GO and KEGG enrichment analysis of targets. Results A total of 192 intersection genes between FZHY and liver cancer and 95 potential compounds were screened out, among which quercetin and luteolin were the active components with an important regulatory role. INS, IL-6, and EGFR were the key targets for the potential effect of FZHY. The GO enrichment analysis showed the involvement in various biological processes such as response to drug and response to oxygen level, and the KEGG enrichment analysis showed the involvement in the signaling pathways including apoptosis and tumor necrosis factor signaling pathways. Conclusion Based on the method of network pharmacology, this study reveals the mechanism of action of multiple targets and targets of FZHY in the treatment of liver cancer, which provides a theoretical basis for clinical and basic scientific research.
- Liver Neoplasms,
- Fuzheng Huayu Decoction,
- Network Pharmacology

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References

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Mechanism of action of Fuzheng Huayu prescription in treatment of liver cancer based on network pharmacology

DOI: 10.3969/j.issn.1001-5256.2021.10.016