Association of serum uric acid-to-creatinine ratio with nonalcoholic fatty liver disease

Cuiping SHAO; Youqing XU

doi:10.3969/j.issn.1001-5256.2021.10.018

Volume 37 Issue 10

Oct. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2021 > 37(10): 2348-2351

PDF( 1887 KB)

Association of serum uric acid-to-creatinine ratio with nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.10.018

Cuiping SHAO,
Youqing XU^,

Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Research funding:

National Science and Technology Major Project (2016ZX10002011)

Received Date: 2021-02-03
Accepted Date: 2021-02-23
Published Date: 2021-10-20

Abstract

Abstract

Objective To investigate the association of serum uric acid (sUA)-to-creatinine (Cr) ratio with nonalcoholic fatty liver disease (NAFLD). Methods A retrospective analysis was performed for the clinical data of 97 patients with NAFLD (NAFLD group) who attended Beijing Tiantan Hospital, Capital Medical University, from January to December 2020, and according to the results of abdominal ultrasound, they were divided into mild group with 33 patients, moderate group with 31 patients, and severe group with 33 patients. Related data were also collected from 36 healthy adults (control group) who underwent physical examination in our hospital during the same period of time. The above groups were compared in terms of sex, age, fasting blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), gamma-glutamyl transpeptidase (GGT), sUA, serum Cr, and sUA/Cr ratio. The independent samples t- test was used for comparison of normally distributed continuous data between two groups, and an analysis of variance was used for comparison between three groups; the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups; the chi-square test was used for comparison of categorical data between groups. The Spearman test was used for correlation analysis, and a multivariate logistic regression analysis was used to investigate the risk factors for NAFLD. Results Compared with the control group, the NAFLD group had significantly higher levels of ALT, AST, TG, GGT, sUA, and sUA/Cr ratio (Z=-4.881, -4.616, -4.221, and -3.563, t=12.974 and 10.710, all P < 0.05) and a significantly lower level of HDL (Z=-5.682, P < 0.05). The severity of NAFLD (mild, moderate or severe) was positively correlated with ALT, TC, and LDL (r=0.291, 0.272, and 0.253, all P < 0.05). The multivariate logistic regression analysis showed that sUA/Cr ratio was an independent risk factor for NAFLD (odds ratio=1.885, 95% confidence interval: 1.162-3.06, P < 0.05). Conclusion There is a significant correlation between sUA/Cr ratio and NAFLD, and sUA/Cr ratio is an independent predictive factor for NAFLD. The sUA/Cr ratio can be monitored to predict the onset of NAFLD, so as to achieve early identification, early diagnosis, and early treatment and improve prognosis.
- Non-Alcoholic Fatty Liver Disease,
- Uric Acid,
- Creatinine

FullText(HTML)

References(18)

References

[1]	COBBINA E, AKHLAGHI F. Non-alcoholic fatty liver disease (NAFLD)-pathogenesis, classification, and effect on drug metabolizing enzymes and transporters[J]. Drug Metab Rev, 2017, 49(2): 197-211. DOI: 10.1080/03602532.2017.1293683.
[2]	National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association; Fatty Liver Expen Committee, Chinese Medical Doctor Association. Guidelines of prevention and treatment for nonalcoholic fatty liver disease: A 2018 update[J]. J Clin Hepatol, 2018, 34(5): 177-186. DOI: 10.3969/j.issn.1672-5069.2018.02.007. 中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会. 非酒精性脂肪性肝病防治指南(2018年更新版)[J]. 临床肝胆病杂志, 2018, 34(5): 177-186. DOI: 10.3969/j.issn.1672-5069.2018.02.007.
[3]	CHALASANI N, YOUNOSSI Z, LAVINE JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association[J]. Hepatology, 2012, 55(6): 2005-2023. DOI: 10.1002/hep.25762.
[4]	LIU S, SONG JY, PENG J, et al. Association of serum uric acid/creatinine ratio and metabolic syndrome in euthyroid population[J]. J Hyg Res, 2020, 49(3): 374-380. DOI: 10.19813/j.cnki.weishengyanjiu.2020.03.005. 刘思, 宋嘉宜, 彭绩, 等. 甲状腺功能正常人群血尿酸/肌酐比值与代谢综合征的相关性[J]. 卫生研究, 2020, 49(3): 374-380. DOI: 10.19813/j.cnki.weishengyanjiu.2020.03.005.
[5]	National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association. Guidelines of clinical diagnosis and treatment for nonalcoholic fatty liver disease[J]. Chin Hepatol, 2006, 11(1): 68-70. DOI: 10.3969/j.issn.1008-1704.2006.01.032. 中华医学会肝病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病诊疗指南[J]. 肝脏, 2006, 11(1): 68-70. DOI: 10.3969/j.issn.1008-1704.2006.01.032.
[6]	YOUNOSSI ZM, KOENIG AB, ABDELATIF D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes[J]. Hepatology, 2016, 64(1): 73-84. DOI: 10.1002/hep.28431.
[7]	BYRNE CD, TARGHER G. NAFLD: A multisystem disease[J]. J Hepatol, 2015, 62(1 Suppl): s47-s64. DOI: 10.1016/j.jhep.2014.12.012.
[8]	MARCUCCILLI M, CHONCHOL M. NAFLD and chronic kidney disease[J]. Int J Mol Sci, 2016, 17(4): 562. DOI: 10.3390/ijms17040562.
[9]	CHEN MY, ZHAO CC, LI TT, et al. Serum uric acid levels are associated with obesity but not cardio-cerebrovascular events in Chinese inpatients with type 2 diabetes[J]. Sci Rep, 2017, 7: 40009. DOI: 10.1038/srep40009.
[10]	LIMA WG, MARTINS-SANTOS ME, CHAVES VE. Uric acid as a modulator of glucose and lipid metabolism[J]. Biochimie, 2015, 116: 17-23. DOI: 10.1016/j.biochi.2015.06.025.
[11]	ALI N, RAHMAN S, ISLAM S, et al. The relationship between serum uric acid and lipid profile in Bangladeshi adults[J]. BMC Cardiovasc Disord, 2019, 19(1): 42. DOI: 10.1186/s12872-019-1026-2.
[12]	AFZALI A, WEISS NS, BOYKO EJ, et al. Association between serum uric acid level and chronic liver disease in the United States[J]. Hepatology, 2010, 52(2): 578-589. DOI: 10.1002/hep.23717.
[13]	KAWAMOTO R, NINOMIYA D, AKASE T, et al. Serum uric acid to creatinine ratio independently predicts incident metabolic syndrome among community-dwelling persons[J]. Metab Syndr Relat Disord, 2019, 17(2): 81-89. DOI: 10.1089/met.2018.0055.
[14]	HWANG IC, SUH SY, SUH AR, et al. The relationship between normal serum uric acid and nonalcoholic fatty liver disease[J]. J Korean Med Sci, 2011, 26(3): 386-391. DOI: 10.3346/jkms.2011.26.3.386.
[15]	MOON SS. Relationship between serum uric acid level and nonalcoholic fatty liver disease in pre- and postmenopausal women[J]. Ann Nutr Metab, 2013, 62(2): 158-163. DOI: 10.1159/000346202.
[16]	SPAHIS S, DELVIN E, BORYS JM, et al. Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis[J]. Antioxid Redox Signal, 2017, 26(10): 519-541. DOI: 10.1089/ars.2016.6776.
[17]	XU C, WAN X, XU L, et al. Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds[J]. J Hepatol, 2015, 62(6): 1412-1419. DOI: 10.1016/j.jhep.2015.01.019.
[18]	SEO YB, HAN AL. Association of the serum uric acid-to-creatinine ratio with nonalcoholic fatty liver disease diagnosed by computed tomography[J]. Metab Syndr Relat Disord, 2021, 19(2): 70-75. DOI: 10.1089/met.2020.0086.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (1010) PDF downloads(89)

Association of serum uric acid-to-creatinine ratio with nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.10.018

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content