Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

Jing LI; Jing XIA; Jie WU

doi:10.3969/j.issn.1001-5256.2021.10.023

Volume 37 Issue 10

Oct. 2021

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2021 > 37(10): 2376-2379

PDF( 1885 KB)

Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

DOI: 10.3969/j.issn.1001-5256.2021.10.023

Jing LI¹,
Jing XIA¹,
Jie WU^{1, 2
,
,}

1.
Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, China
2.
Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China

Received Date: 2021-02-21
Accepted Date: 2021-03-15
Published Date: 2021-10-20

Abstract

Abstract

Objective To investigate the correlation of the levels of fat-soluble vitamins (FSVs) with the changes of related indicators in infants with cholestatic liver disease, and to provide a basis for the supplementation of FSVs in infants with cholestatic liver disease. Methods A total of 136 children with cholestatic liver disease who were hospitalized in Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University, from January 2018 to December 2020 were enrolled as observation group, and 30 healthy infants who underwent physical examination in our hospital during the same period of time were enrolled as control group. Related data were recorded, including gestational age, age in days, sex, and etiology, and related examinations were performed, including liver function, serum calcium, serum phosphorus, coagulation function, etiology, radiological examination, and gene detection. The serum levels of vitamins A, D, E, and K were also measured. The Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups, and the chi-square test was used for comparison of categorical data between groups. Results There were significant differences in the levels of FSVs between the observation group and the control group (vitamin A: Z=-2.850, P= 0.004; vitamin D3: Z=-5.705, P < 0.001; vitamin E: Z=-5.894, P < 0.001; vitamin K: Z=-2.482, P= 0.013), and there were no significant differences in the levels of FSVs between the full-term infants and the preterm infants (all P > 0.05). Serum total bilirubin was significantly correlated with vitamins A and D3 (vitamin A: r=-0.178, P=0.038; vitamin D3: r=-0.296, P < 0.001), and serum direct bilirubin and total bile acid were significantly correlated with vitamin D3 (r=-0.328 and -0.194, both P < 0.05); serum alkaline phosphatase was significantly correlated with vitamins A and D3 (vitamin A: r=-0.282, P= 0.001; vitamin D3: r=-0.514, P < 0.001). Serum vitamin D3 level was positively correlated with serum calcium (r=0.303, P < 0.001) and phosphorus (r=0.310, P < 0.001) and was negatively correlated with alkaline phosphatase (r=-0.514, P < 0.001). There was no significant correlation between serum vitamin K level and coagulation markers (all P > 0.05), while there was a significant change in vitamin K level after treatment (Z=-5.662, P < 0.001). Conclusion The levels of FSVs in children with cholestatic liver disease are significantly lower than those in healthy infants of the same age in days. An increase in serum total bilirubin can indicate the deficiency of vitamins A and D3; increases in serum direct bilirubin and total bile acid can indicate vitamin D3 deficiency; an increase in serum alkaline phosphatase can indicate the deficiency of vitamins A and D3.
- Cholestasis,
- Vitamins,
- Infant

FullText(HTML)

References(15)

References

[1]	FAWAZ R, BAUMANN U, EKONG U, et al. Guideline for the evaluation of cholestatic jaundice in infants: Joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition[J]. J Pediatr Gastroenterol Nutr, 2017, 64(1): 154-168. DOI: 10.1097/MPG.0000000000001334.
[2]	CHEN HL, WU SH, HSU SH, et al. Jaundice revisited: Recent advances in the diagnosis and treatment of inherited cholestatic liver diseases[J]. J Biomed Sci, 2018, 25(1): 75. DOI: 10.1186/s12929-018-0475-8.
[3]	GONCALVES A, ROI S, NOWICKI M, et al. Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption[J]. Food Chem, 2015, 172: 155-160. DOI: 10.1016/j.foodchem.2014.09.021.
[4]	YEUNG CY. Fat-soluble vitamin deficiency in pediatric patients with chronic liver disease[J]. Pediatr Neonatol, 2019, 60(1): 1-2. DOI: 10.1016/j.pedneo.2019.01.003.
[5]	SHEN YM, WU JF, HSU HY, et al. Oral absorbable fat-soluble vitamin formulation in pediatric patients with cholestasis[J]. J Pediatr Gastroenterol Nutr, 2012, 55(5): 587-591. DOI: 10.1097/MPG.0b013e31825c9732.
[6]	MOREIRA-SILVA H, MAIO I, BANDEIRA A, et al. Metabolic liver diseases presenting with neonatal cholestasis: At the crossroad between old and new paradigms[J]. Eur J Pediatr, 2019, 178(4): 515-523. DOI: 10.1007/s00431-019-03328-5.
[7]	OKANO Y, OHURA T, SAKAMOTO O, et al. Current treatment for citrin deficiency during NICCD and adaptation/compensation stages: Strategy to prevent CTLN2[J]. Mol Genet Metab, 2019, 127(3): 175-183. DOI: 10.1016/j.ymgme.2019.06.004.
[8]	ABDEL-RAHMAN N, SHARAWY MH, MEGAHED N, et al. Vitamin D3 abates BDL-induced cholestasis and fibrosis in rats via regulating Hedgehog pathway[J]. Toxicol Appl Pharmacol, 2019, 380: 114697. DOI: 10.1016/j.taap.2019.114697.
[9]	MARCHILI MR, SANTORO E, MARCHESI A, et al. Vitamin K deficiency: A case report and review of current guidelines[J]. Ital J Pediatr, 2018, 44(1): 36. DOI: 10.1186/s13052-018-0474-0.
[10]	AKIYAMA H, OKAMURA Y, NAGASHIMA T, et al. Intracranial hemorrhage and vitamin K deficiency associated with biliary atresia: Summary of 15 cases and review of the literature[J]. Pediatr Neurosurg, 2006, 42(6): 362-367. DOI: 10.1159/000095566.
[11]	LEVY DS, GREWAL R, LE TH. Vitamin K deficiency: An emerging player in the pathogenesis of vascular calcification and an iatrogenic consequence of therapies in advanced renal disease[J]. Am J Physiol Renal Physiol, 2020, 319(4): f618-f623. DOI: 10.1152/ajprenal.00278.2020.
[12]	FREUND C, GOTTHARDT DN. Vitamin A deficiency in chronic cholestatic liver disease: Is vitamin A therapy beneficial?[J]. Liver Int, 2017, 37(12): 1752-1758. DOI: 10.1111/liv.13433.
[13]	ULATOWSKI LM, MANOR D. Vitamin E and neurodegeneration[J]. Neurobiol Dis, 2015, 84: 78-83. DOI: 10.1016/j.nbd.2015.04.002.
[14]	DONG R, SUN S, LIU XZ, et al. Fat-soluble vitamin deficiency in pediatric patients with biliary atresia[J]. Gastroenterol Res Pract, 2017, 2017: 7496860. DOI: 10.1155/2017/7496860.
[15]	VENKAT VL, SHNEIDER BL, MAGEE JC, et al. Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia[J]. J Pediatr Gastroenterol Nutr, 2014, 59(6): 702-707. DOI: 10.1097/MPG.0000000000000547.

Relative Articles

[1]	Ziyun GUO, Lina DU, Xiaoxuan XIE, Yan YANG. Level of vitamin D in children with cholestatic liver disease and its clinical features[J]. Journal of Clinical Hepatology, 2025, 41(1): 99-103. doi: 10.12449/JCH250115
[2]	Jiping ZHANG. Pathological diagnosis of cholestatic liver disease[J]. Journal of Clinical Hepatology, 2024, 40(6): 1093-1099. doi: 10.12449/JCH240605
[3]	Jing LI, Kuiyang ZHENG, Beibei ZHANG. Mechanism of action of bile acid metabolism in regulating cholestatic liver disease and the research and development of drugs[J]. Journal of Clinical Hepatology, 2021, 37(10): 2482-2487. doi: 10.3969/j.issn.1001-5256.2021.10.048
[4]	Jianli ZHOU, Zhaoxia WANG, Shaoming ZHOU, Qiao ZHANG, Xia QIAN. Composition and functional change of intestinal microbiota in infantile cholestasis[J]. Journal of Clinical Hepatology, 2021, 37(1): 126-130. doi: 10.3969/j.issn.1001-5256.2021.01.025
[5]	Kan YanTing, Yang YongFeng. Role of cholestatic liver disease-related genes in intrahepatic cholestasis of pregnancy[J]. Journal of Clinical Hepatology, 2019, 35(7): 1439-1443. doi: 10.3969/j.issn.1001-5256.2019.07.006
[6]	Du LiNa, Yang Yan. Establishment and application of animal models of cholestasis[J]. Journal of Clinical Hepatology, 2019, 35(2): 444-447. doi: 10.3969/j.issn.1001-5256.2019.02.046
[7]	Shen Hong, Hu Meng, Wei ZeHui, Zhang Dong, Zhang JunChang, Tian GuangJun. Bile formation, secretion, and excretion and the pathogenesis of cholestasis[J]. Journal of Clinical Hepatology, 2019, 35(2): 431-437. doi: 10.3969/j.issn.1001-5256.2019.02.043
[8]	Huang CaiZhi, Nie BoLi, Tang Lian, Mo LiYa. Correlation of severity of infantile cholestatic liver disease with serum vitamin D level[J]. Journal of Clinical Hepatology, 2019, 35(8): 1782-1785. doi: 10.3969/j.issn.1001-5256.2019.08.026
[9]	Li XiaoFeng, Gong JingYu, Wang JianShe. Association between enterohepatic circulation of bile acid and cholestatic liver disease[J]. Journal of Clinical Hepatology, 2017, 33(10): 1922-1927. doi: 10.3969/j.issn.1001-5256.2017.10.014
[10]	Xu Feng, Liu XiaoLin, Wang Chao, Dai ChaoLiu. Protective effect of prostaglandin E1 pretreatment against liver ischemia-reperfusion injury in rats with cholestasis[J]. Journal of Clinical Hepatology, 2017, 33(5): 899-904. doi: 10.3969/j.issn.1001-5256.2017.05.022
[11]	Jiang Chao, Huang HeYu, Lu: GuoYue. Perspectives of liver transplantation for infantile cholestatic liver disease[J]. Journal of Clinical Hepatology, 2017, 33(10): 1928-1930. doi: 10.3969/j.issn.1001-5256.2017.10.015
[12]	Pang XiaoLi, Wang ChaoXia. Relationship of intestinal microecology with infantile cholestatic liver disease[J]. Journal of Clinical Hepatology, 2015, 31(8): 1221-1225. doi: 10.3969/j.issn.1001-5256.2015.08.010
[13]	Xu LingFen, Zhang WeiBo, Ma XueMei, Guo Jing, Wang Yang, Sun Mei. Value of tandem mass spectrometry in etiological diagnosis of cholestasis in infants[J]. Journal of Clinical Hepatology, 2015, 31(8): 1257-1261. doi: 10.3969/j.issn.1001-5256.2015.08.018
[14]	Liu Yan, Huang ZhiHua. Clinical diagnosis and treatment of cholestatic hepatopathy in infants[J]. Journal of Clinical Hepatology, 2015, 31(8): 1218-1220. doi: 10.3969/j.issn.1001-5256.2015.08.009
[15]	Jiang Tao, Yao Yu, Ou YangWenXian, Tan YanFang, Li ShuangJie. Intrahepatic cholestasis caused by citrin deficiency: a clinical analysis of 43 infants[J]. Journal of Clinical Hepatology, 2014, 30(11): 1123-1126. doi: 10.3969/j.issn.1001-5256.2014.11.007
[16]	Zhu Peng, Wang YuMing. NASPGHAN practice guidelines: diagnosis and management of hepatitis C infection in infants, children, and adolescents[J]. Journal of Clinical Hepatology, 2013, 29(10): 726-731. doi: 10.3969/j.issn.1001-5256.2013.10.002
[17]	Qu Ying, Xu MingYi, Lu LunGen. Current progress in understanding of cholestasis and autoimmune liver diseases——Meeting review about 1st symposium on cholestasis and autoimmune liver disease[J]. Journal of Clinical Hepatology, 2011, 27(2): 222-225.
[18]	Lu LunGen. Mechanism of bile secretion, excretion, regulation and cholestasis[J]. Journal of Clinical Hepatology, 2011, 27(6): 570-571+580.
[19]	Yang Lu, Sun Mei. Clinical analysis of 145 cases with infantile cholestasis[J]. Journal of Clinical Hepatology, 2011, 27(7): 731-734.
[20]	Zhu QiRong, Wang JianShe. Differential diagnosis of infantile cholestasis[J]. Journal of Clinical Hepatology, 2011, 27(7): 679-681+693.

Supplements(0)

Cited By

Cited by

Periodical cited type(5)

1.	郭紫云，杜丽娜，谢晓暄，杨燕. 胆汁淤积性肝病患儿的维生素D水平及临床特点. 临床肝胆病杂志. 2025(01): 99-103 . 本站查看
2.	贾永娟，邱天祎，刘杏立，刘春冉，倪君君. 正常饮食对脂溶性维生素检测结果的影响. 检验医学. 2024(03): 289-290 .
3.	胡世杰，李栋，郭莉君，张敏，郭薇，张静. 维生素A、D水平与早产儿呼吸道感染肺炎后反复呼吸道感染相关性. 临床军医杂志. 2023(01): 92-94+99 .
4.	王建东，唐玉林，郭亚男，高海慧，侯鹏霞，于洋，郭延生. 基于代谢组学探讨犊牛失明原因. 西南农业学报. 2023(10): 2281-2291 .
5.	周璐，王希涛，宋风丽，马秀华. 化瘀利胆汤结合综合干预治疗妊娠期肝内胆汁淤积症. 长春中医药大学学报. 2022(11): 1234-1237 .

Other cited types(3)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (469) PDF downloads(38)

Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

DOI: 10.3969/j.issn.1001-5256.2021.10.023

Abstract

References

Relative Articles

Cited by

Periodical cited type(5)

Other cited types(3)

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content