Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

Jing LI; Jing XIA; Jie WU

doi:10.3969/j.issn.1001-5256.2021.10.023

Volume 37 Issue 10

Oct. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2021 > 37(10): 2376-2379

PDF( 1885 KB)

Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

DOI: 10.3969/j.issn.1001-5256.2021.10.023

Jing LI¹,
Jing XIA¹,
Jie WU^{1, 2
,
,}

1.
Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, China
2.
Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China

Received Date: 2021-02-21
Accepted Date: 2021-03-15
Published Date: 2021-10-20

Abstract

Abstract

Objective To investigate the correlation of the levels of fat-soluble vitamins (FSVs) with the changes of related indicators in infants with cholestatic liver disease, and to provide a basis for the supplementation of FSVs in infants with cholestatic liver disease. Methods A total of 136 children with cholestatic liver disease who were hospitalized in Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University, from January 2018 to December 2020 were enrolled as observation group, and 30 healthy infants who underwent physical examination in our hospital during the same period of time were enrolled as control group. Related data were recorded, including gestational age, age in days, sex, and etiology, and related examinations were performed, including liver function, serum calcium, serum phosphorus, coagulation function, etiology, radiological examination, and gene detection. The serum levels of vitamins A, D, E, and K were also measured. The Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups, and the chi-square test was used for comparison of categorical data between groups. Results There were significant differences in the levels of FSVs between the observation group and the control group (vitamin A: Z=-2.850, P= 0.004; vitamin D3: Z=-5.705, P < 0.001; vitamin E: Z=-5.894, P < 0.001; vitamin K: Z=-2.482, P= 0.013), and there were no significant differences in the levels of FSVs between the full-term infants and the preterm infants (all P > 0.05). Serum total bilirubin was significantly correlated with vitamins A and D3 (vitamin A: r=-0.178, P=0.038; vitamin D3: r=-0.296, P < 0.001), and serum direct bilirubin and total bile acid were significantly correlated with vitamin D3 (r=-0.328 and -0.194, both P < 0.05); serum alkaline phosphatase was significantly correlated with vitamins A and D3 (vitamin A: r=-0.282, P= 0.001; vitamin D3: r=-0.514, P < 0.001). Serum vitamin D3 level was positively correlated with serum calcium (r=0.303, P < 0.001) and phosphorus (r=0.310, P < 0.001) and was negatively correlated with alkaline phosphatase (r=-0.514, P < 0.001). There was no significant correlation between serum vitamin K level and coagulation markers (all P > 0.05), while there was a significant change in vitamin K level after treatment (Z=-5.662, P < 0.001). Conclusion The levels of FSVs in children with cholestatic liver disease are significantly lower than those in healthy infants of the same age in days. An increase in serum total bilirubin can indicate the deficiency of vitamins A and D3; increases in serum direct bilirubin and total bile acid can indicate vitamin D3 deficiency; an increase in serum alkaline phosphatase can indicate the deficiency of vitamins A and D3.
- Cholestasis,
- Vitamins,
- Infant

FullText(HTML)

References(15)

References

[1]	FAWAZ R, BAUMANN U, EKONG U, et al. Guideline for the evaluation of cholestatic jaundice in infants: Joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition[J]. J Pediatr Gastroenterol Nutr, 2017, 64(1): 154-168. DOI: 10.1097/MPG.0000000000001334.
[2]	CHEN HL, WU SH, HSU SH, et al. Jaundice revisited: Recent advances in the diagnosis and treatment of inherited cholestatic liver diseases[J]. J Biomed Sci, 2018, 25(1): 75. DOI: 10.1186/s12929-018-0475-8.
[3]	GONCALVES A, ROI S, NOWICKI M, et al. Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption[J]. Food Chem, 2015, 172: 155-160. DOI: 10.1016/j.foodchem.2014.09.021.
[4]	YEUNG CY. Fat-soluble vitamin deficiency in pediatric patients with chronic liver disease[J]. Pediatr Neonatol, 2019, 60(1): 1-2. DOI: 10.1016/j.pedneo.2019.01.003.
[5]	SHEN YM, WU JF, HSU HY, et al. Oral absorbable fat-soluble vitamin formulation in pediatric patients with cholestasis[J]. J Pediatr Gastroenterol Nutr, 2012, 55(5): 587-591. DOI: 10.1097/MPG.0b013e31825c9732.
[6]	MOREIRA-SILVA H, MAIO I, BANDEIRA A, et al. Metabolic liver diseases presenting with neonatal cholestasis: At the crossroad between old and new paradigms[J]. Eur J Pediatr, 2019, 178(4): 515-523. DOI: 10.1007/s00431-019-03328-5.
[7]	OKANO Y, OHURA T, SAKAMOTO O, et al. Current treatment for citrin deficiency during NICCD and adaptation/compensation stages: Strategy to prevent CTLN2[J]. Mol Genet Metab, 2019, 127(3): 175-183. DOI: 10.1016/j.ymgme.2019.06.004.
[8]	ABDEL-RAHMAN N, SHARAWY MH, MEGAHED N, et al. Vitamin D3 abates BDL-induced cholestasis and fibrosis in rats via regulating Hedgehog pathway[J]. Toxicol Appl Pharmacol, 2019, 380: 114697. DOI: 10.1016/j.taap.2019.114697.
[9]	MARCHILI MR, SANTORO E, MARCHESI A, et al. Vitamin K deficiency: A case report and review of current guidelines[J]. Ital J Pediatr, 2018, 44(1): 36. DOI: 10.1186/s13052-018-0474-0.
[10]	AKIYAMA H, OKAMURA Y, NAGASHIMA T, et al. Intracranial hemorrhage and vitamin K deficiency associated with biliary atresia: Summary of 15 cases and review of the literature[J]. Pediatr Neurosurg, 2006, 42(6): 362-367. DOI: 10.1159/000095566.
[11]	LEVY DS, GREWAL R, LE TH. Vitamin K deficiency: An emerging player in the pathogenesis of vascular calcification and an iatrogenic consequence of therapies in advanced renal disease[J]. Am J Physiol Renal Physiol, 2020, 319(4): f618-f623. DOI: 10.1152/ajprenal.00278.2020.
[12]	FREUND C, GOTTHARDT DN. Vitamin A deficiency in chronic cholestatic liver disease: Is vitamin A therapy beneficial?[J]. Liver Int, 2017, 37(12): 1752-1758. DOI: 10.1111/liv.13433.
[13]	ULATOWSKI LM, MANOR D. Vitamin E and neurodegeneration[J]. Neurobiol Dis, 2015, 84: 78-83. DOI: 10.1016/j.nbd.2015.04.002.
[14]	DONG R, SUN S, LIU XZ, et al. Fat-soluble vitamin deficiency in pediatric patients with biliary atresia[J]. Gastroenterol Res Pract, 2017, 2017: 7496860. DOI: 10.1155/2017/7496860.
[15]	VENKAT VL, SHNEIDER BL, MAGEE JC, et al. Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia[J]. J Pediatr Gastroenterol Nutr, 2014, 59(6): 702-707. DOI: 10.1097/MPG.0000000000000547.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (404) PDF downloads(36)

Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

DOI: 10.3969/j.issn.1001-5256.2021.10.023

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content