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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 10
Oct.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(10): 2236-2241

Correlation analysis of hepatic fibrosis and renal injury in patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2022.10.008
  • 1.

    Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu 221000, China

  • 2.

    The 71st Group Army Hospital of CPLA Army, Infectious Department, Xuzhou, Jiangsu 221000, China

  • 3.

    The Affiliated Hospital of Xuzhou Medical University, Infectious Department, Xuzhou, Jiangsu 221000, China

  • 4.

    The Affiliated Suqian First People's Hospital of Nanjing Medical University, Infectious Department, Suqian, Jiangsu 223800, China

More Information
  • Corresponding author: YAN Xuebing, yxbxuzhou@126.com(ORCID: 0000-0003-4689-7389)
  • Received Date: 2022-03-09
  • Accepted Date: 2022-04-17
  • Published Date: 2022-10-20
    Abstract
  •   Objective  To analyze the relationship between liver fibrosis and renal injury in patients with chronic hepatitis B (CHB).  Methods  We retrospectively analyzed the renal function of 798 CHB patients who were enrolled from May 2010 to October 2019. According to the quartile of fibrosis-4 (FIB-4) index, the population was divided into four groups: group Q1 (FIB-4≤0.74), group Q2 (0.74 < FIB-4 < 1.13), Q3 group (1.13≤FIB-4 < 2.0), and Q4 group (FIB-4≥2.0). The Mann-Whitney U test was used for comparison of non-normally distributed continuous data between multiple groups. The chi-square test was used for comparison of categorical data between groups. Spearman partial correlation analysis was used to determine the relationship between FIB-4 and estimated glomerular filtration rate (eGFR). Multivariate Logistic regression model was used to assess the risk factors of renal injury using odds ratio (OR) and 95% confidence intervals (CI). Multiple Logistic regression was used to analyze the relationship between FIB-4 and renal injury in different groups.  Results  Because FIB-4 was correlated with age (r=0.650, P < 0.001), Spearman partial correlation analysis was used to adjust for age and gender. We found FIB-4 index was significantly associated with ALT, AST, ALP, GGT, LDH, TBil, DBil, TP, Alb, Glo, TBA, LAP, PLT, HBV DNA, AFP and eGFR (r values were 0.202, 0.354, 0.292, 0.287, 0.222, 0.377, 0.361, -0.085, -0.412, 0.168, 0.422, 0.427, 0.247, -0.421, 0.172, 0.318, -0.359, respectively, all P < 0.001). eGFR was negatively correlated with FIB-4 (R2=0.192 9). Multivariate logistic regression analysis found that HBV DNA(OR=1.227, 95%CI: 1.038-1.452, P=0.017), FIB-4(OR=1.581, 95%CI: 1.359-1.839, P < 0.001) were independent risk factors for renal injury. The AUC value of FIB-4 in predicting renal injury was 0.74 (95%CI: 0.67-0.82, P < 0.001), with a sensitivity of 0.47, a specificity of 0.93, and an optimal cutoff value of 3.48.  Conclusions  The degree of liver fibrosis in CHB patients is associated with the risk of renal injury.

     

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