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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 8
Aug.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(8): 1958-1965

Influence of splenectomy on the course of liver cirrhosis and related mechanism

DOI: 10.3969/j.issn.1001-5256.2023.08.029
  • 1.

    Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

  • 2.

    Department of Digestive Medicine, Jianyang Hospital of Traditional Chinese Medicine, Chengdu 610075, China

  • 3.

    Department of General Medicine, Jianyang People's Hospital, Chengdu 610075, China

Research funding:

Key Technology Research and Development Program of Sichuan Province (2020YFS0301)

More Information
  • Corresponding author: FENG Quansheng, fengqs118@163.com (ORCID: 0000-0003-3437-8987)
  • Received Date: 2022-11-22
  • Accepted Date: 2023-01-20
  • Published Date: 2023-08-20
    Abstract
  • Splenomegaly is a common pathological change of portal hypertension in liver cirrhosis and can progress to hypersplenism, leading to the reduction in blood cells and increasing the risk of clinical bleeding and infection. Splenectomy is an important method for the treatment of splenectomy with hypersplenism, but it faces the risks of infection, surgical bleeding, postoperative thrombosis, and postoperative pancreatic fistula. However, with the gradual deepening of modern research, it has been found that patients with liver cirrhosis have a certain degree of improvement after splenectomy, such as the reduced risk of gastrointestinal bleeding, a reduction in portal venous pressure, the improvement in the hemodynamics of internal organs, the promotion of liver tissue regeneration, the improvement in liver fibrosis, the regulation of immune function, the improvement in nutritional status, and the reduced risk of liver cancer. With reference to available clinical and experimental studies, this article reviews the influence of splenectomy on the course of liver cirrhosis and actively explores related mechanism, in order to provide reliable reference and basis for the selection and implementation of splenectomy in clinical practice.

     

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